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    CMKLR2 chemerin chemokine-like receptor 2 [ Homo sapiens (human) ]

    Gene ID: 2825, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CMKLR2provided by HGNC
    Official Full Name
    chemerin chemokine-like receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:4463
    See related
    Ensembl:ENSG00000183671 MIM:600239; AllianceGenome:HGNC:4463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR1
    Summary
    Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Predicted to be involved in glucose homeostasis and neuropeptide signaling pathway. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta (RPKM 1.8), esophagus (RPKM 1.0) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CMKLR2 in Genome Data Viewer
    Location:
    2q33.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (206175316..206217912, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (206657211..206699815, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (207040040..207082636, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 beta 2 Neighboring gene small nucleolar RNA, C/D box 51 Neighboring gene small nucleolar RNA, H/ACA box 41 Neighboring gene CMKLR2 antisense RNA Neighboring gene RN7SK pseudogene 200 Neighboring gene ATP5PO pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Chemerin causes lipid metabolic imbalance and induces passive lipid accumulation in human hepatoma cell line via the receptor GPR1. Zhu L, et al. Life Sci, 2021 Aug 1. PMID 33887347
    2. An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells. Shimizu N, et al. J Virol, 1999 Jun. PMID 10233994, Free PMC Article
    3. International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin(1)) and GPR1 (Chemerin(2)) Nomenclature, Pharmacology, and Function. Kennedy AJ, et al. Pharmacol Rev, 2018 Jan. PMID 29279348, Free PMC Article
    4. The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 HIV-1. Jinno-Oue A, et al. J Biol Chem, 2005 Sep 2. PMID 15919664
    5. The Atypical Chemerin Receptor GPR1 Displays Different Modes of Interaction with β-Arrestins in Humans and Mice with Important Consequences on Subcellular Localization and Trafficking. Degroot GN, et al. Cells, 2022 Mar 18. PMID 35326488, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure of G protein-coupled receptor GPR1 bound to full-length chemerin adipokine reveals a chemokine-like reverse binding mode.
      Title: Structure of G protein-coupled receptor GPR1 bound to full-length chemerin adipokine reveals a chemokine-like reverse binding mode.
    2. The Atypical Chemerin Receptor GPR1 Displays Different Modes of Interaction with beta-Arrestins in Humans and Mice with Important Consequences on Subcellular Localization and Trafficking.
      Title: The Atypical Chemerin Receptor GPR1 Displays Different Modes of Interaction with β-Arrestins in Humans and Mice with Important Consequences on Subcellular Localization and Trafficking.
    3. Chemerin causes lipid metabolic imbalance and induces passive lipid accumulation in human hepatoma cell line via the receptor GPR1.
      Title: Chemerin causes lipid metabolic imbalance and induces passive lipid accumulation in human hepatoma cell line via the receptor GPR1.
    4. Chemerin Isoform-Specific Effects on Hepatocyte Migration and Immune Cell Inflammation.
      Title: Chemerin Isoform-Specific Effects on Hepatocyte Migration and Immune Cell Inflammation.
    5. GPR1 protein and gene levels were significantly decreased in gestational diabetes mellitus patient placentas.
      Title: Impact of GPR1 signaling on maternal high-fat feeding and placenta metabolism in mice.
    6. The majority of presented data report down-regulation of chemerin in cancer tissue and suggest a tumor-suppressing role of chemerin in most cancer types, being mediated by recruiting innate immune defenses and by growth-inhibitory downstream signaling by chemerin receptors CMKLR1 and GPR1. (Review)
      Title: Chemerin and Cancer.
    7. CMKLR1 and GPR1 were widely expressed in vascular smooth muscle.
      Title: Chemerin Elicits Potent Constrictor Actions via Chemokine-Like Receptor 1 (CMKLR1), not G-Protein-Coupled Receptor 1 (GPR1), in Human and Rat Vasculature.
    8. The Gene-based analyses revealed four significant associations in the WT1, ZC3H12C, DLGAP2, and GPR1 genes at p < 0.05. in this study.
      Title: Genetic variation in imprinted genes is associated with risk of late-onset Alzheimer's disease.
    9. GPR1 gene is imprinted and paternally expressed in human and mouse.
      Title: A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip.
    10. identified homologous amino acid sequences in amino-terminal regions between CCR5 and GPR1/ sequences are important for G protein-coupled receptors to make the conformation critical for the interaction with the Env protein of HIV-1.
      Title: Short communication: identification of the conformational requirement for the specificities of coreceptors for human and simian immunodeficiency viruses.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Mesangial cells, an important component of the glomerulus, are susceptible to HIV-1 strains for which the viral gp120 protein uses GPR1 as a coreceptor PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adipokinetic hormone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adipokinetic hormone receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chemerin-like receptor 2
    Names
    G protein-coupled receptor 1
    chemokine-like receptor 2
    probable G-protein coupled receptor 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098199.2 → NP_001091669.1  chemerin-like receptor 2

      See identical proteins and their annotated locations for NP_001091669.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      BC067833, BX094581, BX389743, DA692381, DA988428
      Consensus CDS
      CCDS2368.1
      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
      Conserved Domains (1) summary
      cd15119
      Location:39 → 315
      7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001261452.2 → NP_001248381.1  chemerin-like receptor 2

      See identical proteins and their annotated locations for NP_001248381.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AK312917, BC067833, DA988428, EF577403
      Consensus CDS
      CCDS2368.1
      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
      Related
      ENSP00000397535.1, ENST00000437420.5
      Conserved Domains (1) summary
      cd15119
      Location:39 → 315
      7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001261453.2 → NP_001248382.1  chemerin-like receptor 2

      See identical proteins and their annotated locations for NP_001248382.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      BC067833, DA545892, DA988428, EF577403
      Consensus CDS
      CCDS2368.1
      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
      Conserved Domains (1) summary
      cd15119
      Location:39 → 315
      7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_001261454.1 → NP_001248383.1  chemerin-like receptor 2

      See identical proteins and their annotated locations for NP_001248383.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      BC067833, BP279126, EF577403
      Consensus CDS
      CCDS2368.1
      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
      Conserved Domains (1) summary
      cd15119
      Location:39 → 315
      7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. NM_001261455.1 → NP_001248384.1  chemerin-like receptor 2

      See identical proteins and their annotated locations for NP_001248384.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AK312917, BC067833, BP279126, DA733626, EF577403
      Consensus CDS
      CCDS2368.1
      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
      Conserved Domains (1) summary
      cd15119
      Location:39 → 315
      7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

    6. NM_001389445.1 → NP_001376374.1  chemerin-like receptor 2

      Status: VALIDATED

      Source sequence(s)
      AC007383, AK075130
      Consensus CDS
      CCDS2368.1
      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
      Related
      ENSP00000483003.1, ENST00000621141.5
      Conserved Domains (1) summary
      cd15119
      Location:39 → 315
      7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

    7. NM_005279.4 → NP_005270.2  chemerin-like receptor 2

      See identical proteins and their annotated locations for NP_005270.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and all other variants encode the same protein.
      Source sequence(s)
      BC067833, BX094581, BX389743, DA692381, DA988428
      Consensus CDS
      CCDS2368.1
      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
      Related
      ENSP00000384345.2, ENST00000407325.6
      Conserved Domains (1) summary
      cd15119
      Location:39 → 315
      7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      206175316..206217912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443968.1 → XP_047299924.1  chemerin-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_015495299.1 Reference GRCh38.p14 PATCHES

      Range
      284334..326930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331981.1 → XP_054187956.1  chemerin-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4

    2. XM_054331980.1 → XP_054187955.1  chemerin-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      206657211..206699815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341421.1 → XP_054197396.1  chemerin-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4

    2. XM_054341420.1 → XP_054197395.1  chemerin-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      A5JUU6, A8K4L1, P46091, Q53TR9, Q6NVX4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46091.2 GenPept UniProtKB/Swiss-Prot:P46091

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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