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    TTC13 tetratricopeptide repeat domain 13 [ Homo sapiens (human) ]

    Gene ID: 79573, updated on 27-Nov-2024

    Summary

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    Official Symbol
    TTC13provided by HGNC
    Official Full Name
    tetratricopeptide repeat domain 13provided by HGNC
    Primary source
    HGNC:HGNC:26204
    See related
    Ensembl:ENSG00000143643 AllianceGenome:HGNC:26204
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in lymph node (RPKM 8.0), spleen (RPKM 5.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TTC13 in Genome Data Viewer
    Location:
    1q42.2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (230906243..230978861, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (230286691..230359339, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (231041989..231114607, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373167 Neighboring gene uncharacterized LOC124904844 Neighboring gene RNA, 7SL, cytoplasmic 837, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:231037919-231038420 Neighboring gene MPRA-validated peak762 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2720 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2721 Neighboring gene ARV1 homolog, fatty acid homeostasis modulator Neighboring gene microRNA 1182 Neighboring gene family with sequence similarity 89 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TTC13 expression and STAT3 activation may form a positive feedback loop to promote ccRCC progression. Xie L, et al. PeerJ, 2023. PMID 37927783, Free PMC Article
    2. HIV-host interactome revealed directly from infected cells. Luo Y, et al. Nat Microbiol, 2016 Jul. PMID 27375898, Free PMC Article
    3. Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network. Kattan RE, et al. Mol Cell Proteomics, 2022 Feb. PMID 35007762, Free PMC Article
    4. Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis. Li J, et al. Med, 2021 Jan 15. PMID 32838362, Free PMC Article
    5. Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation. Weith M, et al. Mol Cell, 2018 Nov 15. PMID 30344098

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TTC13 expression and STAT3 activation may form a positive feedback loop to promote ccRCC progression.
      Title: TTC13 expression and STAT3 activation may form a positive feedback loop to promote ccRCC progression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with TTC13 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22584

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 13
    Names
    TPR repeat protein 13
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122835.3 → NP_001116307.2  tetratricopeptide repeat protein 13 isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the middle portion of the coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AK075386, AK075561, BC047662, DA741498, EL946523
      Consensus CDS
      CCDS44332.2
      UniProtKB/TrEMBL
      Q69YR0
      Related
      ENSP00000355622.4, ENST00000366662.8
      Conserved Domains (4) summary
      sd00006
      Location:196 → 224
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:264 → 297
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:229 → 294
      TPR_11; TPR repeat
      pfam13424
      Location:149 → 228
      TPR_12; Tetratricopeptide repeat

    2. NM_001376507.1 → NP_001363436.1  tetratricopeptide repeat protein 13 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
      UniProtKB/TrEMBL
      Q69YR0
      Conserved Domains (2) summary
      TIGR02917
      Location:119 → 387
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:218 → 246
      TPR; TPR repeat [structural motif]

    3. NM_001376508.1 → NP_001363437.1  tetratricopeptide repeat protein 13 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
      UniProtKB/TrEMBL
      Q69YR0
      Conserved Domains (2) summary
      COG0457
      Location:114 → 275
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:179 → 204
      TPR; TPR repeat [structural motif]

    4. NM_001376509.1 → NP_001363438.1  tetratricopeptide repeat protein 13 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
      UniProtKB/TrEMBL
      Q69YR0
      Conserved Domains (2) summary
      TIGR02917
      Location:126 → 310
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:188 → 216
      TPR; TPR repeat [structural motif]

    5. NM_001376510.1 → NP_001363439.1  tetratricopeptide repeat protein 13 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
      UniProtKB/TrEMBL
      Q69YR0
      Conserved Domains (2) summary
      TIGR02917
      Location:119 → 418
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:249 → 277
      TPR; TPR repeat [structural motif]

    6. NM_001376511.1 → NP_001363440.1  tetratricopeptide repeat protein 13 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
      UniProtKB/TrEMBL
      Q69YR0
      Conserved Domains (2) summary
      COG0457
      Location:145 → 329
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:196 → 224
      TPR; TPR repeat [structural motif]

    7. NM_001376512.1 → NP_001363441.1  tetratricopeptide repeat protein 13 isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
      UniProtKB/TrEMBL
      Q69YR0
      Conserved Domains (2) summary
      COG0457
      Location:139 → 306
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:241 → 269
      TPR; TPR repeat [structural motif]

    8. NM_001376513.1 → NP_001363442.1  tetratricopeptide repeat protein 13 isoform 9 precursor

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
      UniProtKB/TrEMBL
      Q69YR0
      Conserved Domains (2) summary
      TIGR02917
      Location:119 → 387
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:218 → 246
      TPR; TPR repeat [structural motif]

    9. NM_001376514.1 → NP_001363443.1  tetratricopeptide repeat protein 13 isoform 10 precursor

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
      UniProtKB/TrEMBL
      Q69YR0
      Conserved Domains (2) summary
      TIGR02917
      Location:126 → 310
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:188 → 216
      TPR; TPR repeat [structural motif]

    10. NM_024525.5 → NP_078801.3  tetratricopeptide repeat protein 13 isoform a precursor

      See identical proteins and their annotated locations for NP_078801.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK074365, AK075386, AK075561, DA468037, DA741498, EL946523
      Consensus CDS
      CCDS1588.1
      UniProtKB/Swiss-Prot
      B1AQI1, B1AQI2, Q8IVP8, Q8NBI0, Q8NBP0, Q8ND20
      UniProtKB/TrEMBL
      A0A384NPL4, Q69YR0
      Related
      ENSP00000355621.4, ENST00000366661.9
      Conserved Domains (2) summary
      sd00006
      Location:249 → 277
      TPR; TPR repeat [structural motif]
      cl26002
      Location:119 → 418
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      230906243..230978861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711814.3 → XP_006711877.1  tetratricopeptide repeat protein 13 isoform X2

      UniProtKB/TrEMBL
      Q69YR0
      Conserved Domains (4) summary
      sd00006
      Location:188 → 216
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:188 → 221
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:189 → 253
      TPR_11; TPR repeat
      pfam13424
      Location:149 → 215
      TPR_12; Tetratricopeptide repeat

    2. XM_047430306.1 → XP_047286262.1  tetratricopeptide repeat protein 13 isoform X3

    3. XM_005273264.3 → XP_005273321.1  tetratricopeptide repeat protein 13 isoform X1

      UniProtKB/TrEMBL
      Q69YR0
      Conserved Domains (3) summary
      sd00006
      Location:241 → 269
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:241 → 274
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:242 → 306
      TPR_11; TPR repeat

    4. XM_047430313.1 → XP_047286269.1  tetratricopeptide repeat protein 13 isoform X4

    5. XM_011544276.3 → XP_011542578.1  tetratricopeptide repeat protein 13 isoform X5

      Conserved Domains (3) summary
      sd00006
      Location:19 → 49
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:20 → 53
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:21 → 85
      TPR_11; TPR repeat

    6. XM_047430332.1 → XP_047286288.1  tetratricopeptide repeat protein 13 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      230286691..230359339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338715.1 → XP_054194690.1  tetratricopeptide repeat protein 13 isoform X14

    2. XM_054338714.1 → XP_054194689.1  tetratricopeptide repeat protein 13 isoform X13

    3. XM_054338712.1 → XP_054194687.1  tetratricopeptide repeat protein 13 isoform X2

    4. XM_054338710.1 → XP_054194685.1  tetratricopeptide repeat protein 13 isoform X12

    5. XM_054338709.1 → XP_054194684.1  tetratricopeptide repeat protein 13 isoform X11

    6. XM_054338713.1 → XP_054194688.1  tetratricopeptide repeat protein 13 isoform X3

    7. XM_054338708.1 → XP_054194683.1  tetratricopeptide repeat protein 13 isoform X10

    8. XM_054338707.1 → XP_054194682.1  tetratricopeptide repeat protein 13 isoform X9

    9. XM_054338711.1 → XP_054194686.1  tetratricopeptide repeat protein 13 isoform X1

    10. XM_054338706.1 → XP_054194681.1  tetratricopeptide repeat protein 13 isoform X8

    11. XM_054338705.1 → XP_054194680.1  tetratricopeptide repeat protein 13 isoform X7

    12. XM_054338716.1 → XP_054194691.1  tetratricopeptide repeat protein 13 isoform X4

    13. XM_054338717.1 → XP_054194692.1  tetratricopeptide repeat protein 13 isoform X5

    14. XM_054338718.1 → XP_054194693.1  tetratricopeptide repeat protein 13 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NBP0.3 GenPept UniProtKB/Swiss-Prot:Q8NBP0

    Gene LinkOut

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