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    Elmo2 engulfment and cell motility 2 [ Mus musculus (house mouse) ]

    Gene ID: 140579, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Elmo2provided by MGI
    Official Full Name
    engulfment and cell motility 2provided by MGI
    Primary source
    MGI:MGI:2153045
    See related
    Ensembl:ENSMUSG00000017670 AllianceGenome:MGI:2153045
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CED-12; 1190002F24Rik
    Summary
    Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in actin filament organization and cell chemotaxis. Predicted to be located in cytosol and membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; liver; nervous system; and retina. Orthologous to human ELMO2 (engulfment and cell motility 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 32.9), frontal lobe adult (RPKM 28.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Elmo2 in Genome Data Viewer
    Location:
    2 H3; 2 85.53 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165129951..165168421, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165288031..165326479, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 25569 Neighboring gene solute carrier family 35, member C2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:165147221-165147404 Neighboring gene STARR-positive B cell enhancer ABC_E418 Neighboring gene zinc finger protein 663 Neighboring gene predicted gene, 29831 Neighboring gene STARR-seq mESC enhancer starr_06348 Neighboring gene zinc finger protein 334

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ClipR-59 interacts with Elmo2 and modulates myoblast fusion. Sun Y, et al. J Biol Chem, 2015 Mar 6. PMID 25572395, Free PMC Article
    2. Differential distribution of ELMO1 and ELMO2 mRNAs in the developing mouse brain. Katoh H, et al. Brain Res, 2006 Feb 16. PMID 16443196
    3. Integrin-linked kinase interactions with ELMO2 modulate cell polarity. Ho E, et al. Mol Biol Cell, 2009 Jul. PMID 19439446, Free PMC Article
    4. An ELMO2-RhoG-ILK network modulates microtubule dynamics. Jackson BC, et al. Mol Biol Cell, 2015 Jul 15. PMID 25995380, Free PMC Article
    5. Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds. Weng Z, et al. Nat Commun, 2019 Jan 3. PMID 30604775, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study demonstrated that an evolutionarily conserved fragment in the C-terminal cytoplasmic tail of BAI-aGPCRs is specifically recognized by the RBD-ARR-ELMO (RAE) supramodule of the ELMO family scaffolds. The crystal structures of ELMO2-RAE and its complex with BAI1 uncover the molecular basis of BAI/ELMO interactions.
      Title: Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds.
    2. Ilk and ELMO2 modulate recycling endosomes in keratinocytes undergoing intercellular adhesion mediated through cell-cell contacts, including E-cadherin-based adherens junctions.
      Title: Integrin-linked kinase and ELMO2 modulate recycling endosomes in keratinocytes.
    3. studies demonstrate that Elmo2 is a new regulator of insulin-dependent Glut4 membrane translocation through modulating Rac1 activity and Akt membrane compartmentalization.
      Title: Elmo2 Is a Regulator of Insulin-dependent Glut4 Membrane Translocation.
    4. ELMO2-RhoG-ILK complex has a key role in integrin-independent stabilization of the microtubule network in differentiated keratinocytes.
      Title: An ELMO2-RhoG-ILK network modulates microtubule dynamics.
    5. Collectively, our studies demonstrate that formation of an Elmo2.ClipR-59 complex plays an important role in myoblast fusion.
      Title: ClipR-59 interacts with Elmo2 and modulates myoblast fusion.
    6. Resutls show that the interaction with ELMO2 and RhoG is essential for the ability of ILK to induce front-rear cell polarity.
      Title: Integrin-linked kinase interactions with ELMO2 modulate cell polarity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • mKIAA1834

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    engulfment and cell motility protein 2
    Names
    CED-12 homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302752.1 → NP_001289681.1  engulfment and cell motility protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001289681.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate exon in the 5' UTR and lacks an in-frame exon in the coding region compared to variant 2. It encodes isoform 3, which is shorter than isoform 2. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AK035710, AK038455, AW049501
      Consensus CDS
      CCDS17075.1
      UniProtKB/Swiss-Prot
      Q8BHL5
      Related
      ENSMUSP00000099380.3, ENSMUST00000103091.9
      Conserved Domains (3) summary
      cd13359
      Location:539 → 668
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:295 → 474
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 271
      DUF3361; Domain of unknown function (DUF3361)

    2. NM_001302754.1 → NP_001289683.1  engulfment and cell motility protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001289683.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate in-frame splice site in the 5' coding region, and lacks an exon in the coding region compared to variant 2. It encodes isoform 4, which is shorter than isoform 2.
      Source sequence(s)
      AK033918, AK035710, AK038455, AW049501
      UniProtKB/Swiss-Prot
      Q8BHL5
      Conserved Domains (3) summary
      cd13359
      Location:537 → 666
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:295 → 467
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:115 → 269
      DUF3361; Domain of unknown function (DUF3361)

    3. NM_080287.2 → NP_525026.2  engulfment and cell motility protein 2 isoform 3

      See identical proteins and their annotated locations for NP_525026.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region compared to variant 2. It encodes isoform 3, which is shorter than isoform 2. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AI666775, AK035710, AK045428, BC033418
      Consensus CDS
      CCDS17075.1
      UniProtKB/Swiss-Prot
      Q8BHL5
      Related
      ENSMUSP00000091887.5, ENSMUST00000094329.11
      Conserved Domains (3) summary
      cd13359
      Location:539 → 668
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:295 → 474
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 271
      DUF3361; Domain of unknown function (DUF3361)

    4. NM_207706.1 → NP_997589.1  engulfment and cell motility protein 2 isoform 2

      See identical proteins and their annotated locations for NP_997589.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AI666775, AK032033, AK035710, AK045428
      Consensus CDS
      CCDS17076.1
      UniProtKB/Swiss-Prot
      A2A5A6, Q5GMG3, Q8BHL5, Q8BHL9, Q8BQG1, Q8CBM8, Q8CC50, Q8CH98, Q91ZU2, Q9CT75
      Related
      ENSMUSP00000073691.7, ENSMUST00000074046.13
      Conserved Domains (3) summary
      cd13359
      Location:551 → 680
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:308 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:115 → 283
      DUF3361; Domain of unknown function (DUF3361)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      165129951..165168421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158276.1 → XP_036014169.1  engulfment and cell motility protein 2 isoform X3

      Conserved Domains (3) summary
      cd13359
      Location:522 → 651
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:278 → 457
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 252
      DUF3361; Domain of unknown function (DUF3361)

    2. XM_036158272.1 → XP_036014165.1  engulfment and cell motility protein 2 isoform X2

      Conserved Domains (3) summary
      cd13359
      Location:539 → 668
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:295 → 474
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 271
      DUF3361; Domain of unknown function (DUF3361)

    3. XM_017315487.2 → XP_017170976.1  engulfment and cell motility protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A2A5A6, Q5GMG3, Q8BHL5, Q8BHL9, Q8BQG1, Q8CBM8, Q8CC50, Q8CH98, Q91ZU2, Q9CT75
      Conserved Domains (3) summary
      cd13359
      Location:551 → 680
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:308 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:115 → 283
      DUF3361; Domain of unknown function (DUF3361)

    4. XM_011239284.2 → XP_011237586.1  engulfment and cell motility protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011237586.1

      UniProtKB/Swiss-Prot
      A2A5A6, Q5GMG3, Q8BHL5, Q8BHL9, Q8BQG1, Q8CBM8, Q8CC50, Q8CH98, Q91ZU2, Q9CT75
      Conserved Domains (3) summary
      cd13359
      Location:551 → 680
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:308 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:115 → 283
      DUF3361; Domain of unknown function (DUF3361)

    5. XM_011239285.2 → XP_011237587.1  engulfment and cell motility protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011237587.1

      UniProtKB/Swiss-Prot
      A2A5A6, Q5GMG3, Q8BHL5, Q8BHL9, Q8BQG1, Q8CBM8, Q8CC50, Q8CH98, Q91ZU2, Q9CT75
      Conserved Domains (3) summary
      cd13359
      Location:551 → 680
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:308 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:115 → 283
      DUF3361; Domain of unknown function (DUF3361)

    6. XM_011239286.4 → XP_011237588.1  engulfment and cell motility protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011237588.1

      UniProtKB/Swiss-Prot
      Q8BHL5
      Conserved Domains (3) summary
      cd13359
      Location:539 → 668
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:295 → 474
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 271
      DUF3361; Domain of unknown function (DUF3361)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_207704.1: Suppressed sequence

      Description
      NM_207704.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

    2. NM_207705.1: Suppressed sequence

      Description
      NM_207705.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHL5.1 GenPept UniProtKB/Swiss-Prot:Q8BHL5

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