Arih2 ariadne RBR E3 ubiquitin protein ligase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arih2provided by MGI
Official Full Name: ariadne RBR E3 ubiquitin protein ligase 2provided by MGI
Primary source: MGI:MGI:1344361
See related: Ensembl:ENSMUSG00000064145 AllianceGenome:MGI:1344361
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARI2; UIP48; TRIAD1
Summary: Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of Cul5-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 32.8), thymus adult (RPKM 11.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.54 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (108480141..108531917, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (108602942..108653681, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation.
Title: Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation.
HOXA10 gene disruption exhibited an overwhelming and fatal emergency granulopoiesis response that was characterized by tissue infiltration with granulocytes, but reversed by re-expression of Triad1 in the bone marrow.
Title: HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1.
essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system
Title: ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system.
HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1
Title: HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1.
proteasomal degradation of proteins that are ubiquitinated by Triad1 affects the clonogenic growth of primary myeloid progenitor cells
Title: The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H05L03.2 (e-PCR)
- UniSTS:311318

AI843547 (e-PCR)
- UniSTS:164421

D9Dcr112 (e-PCR), detects polymorphism
- UniSTS:499014

D9Dcr113 (e-PCR), detects polymorphism
- UniSTS:499015

D9Mit116 (e-PCR), detects polymorphism
- UniSTS:131665

RH127724 (e-PCR)
- UniSTS:211034

AJ130975 (e-PCR)
- UniSTS:163469

D9Mit212 (e-PCR), detects polymorphism
- UniSTS:131770

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in developmental cell growth	ISO Inferred from Sequence Orthology more info
involved_in developmental cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic stem cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IPI Inferred from Physical Interaction more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul5-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul5-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase ARIH2

Names: ARI-2; RING-type E3 ubiquitin transferase ARIH2; ariadne 2; ariadne homolog 2; protein ariadne-2 homolog; ubcM4-interacting protein 48

NP_001344212.1

EC 2.3.2.31

NP_001344214.1

EC 2.3.2.31

NP_001344215.1

EC 2.3.2.31

NP_001407995.1

EC 2.3.2.31

NP_035920.1

EC 2.3.2.31

XP_011241183.1

EC 2.3.2.31

XP_030100211.1

EC 2.3.2.31

XP_030100212.1

EC 2.3.2.31

XP_036010821.1

EC 2.3.2.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357283.2 → NP_001344212.1 E3 ubiquitin-protein ligase ARIH2 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).

Source sequence(s)

CT571271

Consensus CDS

CCDS23534.1

UniProtKB/Swiss-Prot

Q9Z1K6

UniProtKB/TrEMBL

Q3TK92

Conserved Domains (3) summary

smart00647
Location:207 → 269

IBR; In Between Ring fingers

cd16773
Location:136 → 189

RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

pfam01485
Location:297 → 329

IBR; IBR domain, a half RING-finger domain
NM_001357285.1 → NP_001344214.1 E3 ubiquitin-protein ligase ARIH2 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).

Source sequence(s)

AK167104, BC051998, CT571271

Consensus CDS

CCDS23534.1

UniProtKB/Swiss-Prot

Q9Z1K6

UniProtKB/TrEMBL

Q3TK92

Conserved Domains (3) summary

smart00647
Location:207 → 269

IBR; In Between Ring fingers

cd16773
Location:136 → 189

RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

pfam01485
Location:297 → 329

IBR; IBR domain, a half RING-finger domain
NM_001357286.2 → NP_001344215.1 E3 ubiquitin-protein ligase ARIH2 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.z

Source sequence(s)

CT571271

Conserved Domains (3) summary

smart00647
Location:136 → 198

IBR; In Between Ring fingers

cd16773
Location:65 → 118

RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

pfam01485
Location:226 → 258

IBR; IBR domain, a half RING-finger domain
NM_001421066.1 → NP_001407995.1 E3 ubiquitin-protein ligase ARIH2 isoform b

Status: VALIDATED

Source sequence(s)

CT571271
NM_011790.6 → NP_035920.1 E3 ubiquitin-protein ligase ARIH2 isoform a

See identical proteins and their annotated locations for NP_035920.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1-3 all encode the same isoform (a).

Source sequence(s)

CT571271

Consensus CDS

CCDS23534.1

UniProtKB/Swiss-Prot

Q9Z1K6

UniProtKB/TrEMBL

Q3TK92

Related

ENSMUSP00000013338.9, ENSMUST00000013338.14

Conserved Domains (3) summary

smart00647
Location:207 → 269

IBR; In Between Ring fingers

cd16773
Location:136 → 189

RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

pfam01485
Location:297 → 329

IBR; IBR domain, a half RING-finger domain

RNA

NR_151664.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

CT571271

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

108480141..108531917 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244352.1 → XP_030100212.1 E3 ubiquitin-protein ligase ARIH2 isoform X1

UniProtKB/Swiss-Prot

Q9Z1K6

UniProtKB/TrEMBL

Q3TK92

Conserved Domains (3) summary

smart00647
Location:207 → 269

IBR; In Between Ring fingers

cd16773
Location:136 → 189

RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

pfam01485
Location:297 → 329

IBR; IBR domain, a half RING-finger domain
XM_030244351.2 → XP_030100211.1 E3 ubiquitin-protein ligase ARIH2 isoform X1

UniProtKB/Swiss-Prot

Q9Z1K6

UniProtKB/TrEMBL

Q3TK92

Conserved Domains (3) summary

smart00647
Location:207 → 269

IBR; In Between Ring fingers

cd16773
Location:136 → 189

RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

pfam01485
Location:297 → 329

IBR; IBR domain, a half RING-finger domain
XM_036154928.1 → XP_036010821.1 E3 ubiquitin-protein ligase ARIH2 isoform X2

Conserved Domains (3) summary

smart00647
Location:136 → 198

IBR; In Between Ring fingers

cd16773
Location:65 → 118

RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

pfam01485
Location:226 → 258

IBR; IBR domain, a half RING-finger domain
XM_011242881.4 → XP_011241183.1 E3 ubiquitin-protein ligase ARIH2 isoform X3

UniProtKB/TrEMBL

A0A0A6YXB0

Related

ENSMUSP00000141914.2, ENSMUST00000193190.6

Conserved Domains (2) summary

smart00647
Location:207 → 269

IBR; In Between Ring fingers

cd16773
Location:136 → 189

RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)