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    Top6bl TOP6B like initiator of meiotic double strand breaks [ Mus musculus (house mouse) ]

    Gene ID: 381196, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Top6blprovided by MGI
    Official Full Name
    TOP6B like initiator of meiotic double strand breaksprovided by MGI
    Primary source
    MGI:MGI:2685806
    See related
    Ensembl:ENSMUSG00000071691 AllianceGenome:MGI:2685806
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm960; TOPOVIBL
    Summary
    Predicted to enable DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in meiotic DNA double-strand break formation and reciprocal meiotic recombination. Predicted to be located in chromosome. Is expressed in ovary; primary oocyte; secondary oocyte; and testis. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to human C11orf80 (chromosome 11 open reading frame 80). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 1.6), whole brain E14.5 (RPKM 0.8) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Top6bl in Genome Data Viewer
    Location:
    19 A; 19 4.08 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4675758..4748753, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4625734..4698713, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene pyruvate carboxylase Neighboring gene leucine rich repeat and fibronectin type III domain containing 4 Neighboring gene microRNA 6986 Neighboring gene Ras converting CAAX endopeptidase 1 Neighboring gene spectrin beta, non-erythrocytic 2 Neighboring gene STARR-positive B cell enhancer ABC_E1967 Neighboring gene predicted gene 21992 Neighboring gene RNA binding motif protein 4B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks. Nore A, et al. Nat Commun, 2022 Nov 17. PMID 36396648, Free PMC Article
    2. Causative Mutations and Mechanism of Androgenetic Hydatidiform Moles. Nguyen NMP, et al. Am J Hum Genet, 2018 Nov 1. PMID 30388401, Free PMC Article
    3. The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Robert T, et al. Science, 2016 Feb 26. PMID 26917764
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.
      Title: TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic DNA double-strand break formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic DNA double-strand break formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    type 2 DNA topoisomerase 6 subunit B-like
    Names
    type 2 DNA topoisomerase VI subunit B-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033447.4 → NP_001028619.3  type 2 DNA topoisomerase 6 subunit B-like

      Status: VALIDATED

      Source sequence(s)
      AC128739, AC147618
      Consensus CDS
      CCDS57129.1
      Related
      ENSMUSP00000153439.2, ENSMUST00000225896.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4675758..4748753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248638.4 → XP_011246940.1  type 2 DNA topoisomerase 6 subunit B-like isoform X5

      UniProtKB/TrEMBL
      A0A182DWE7
      Conserved Domains (1) summary
      pfam15091
      Location:274 → 644
      DUF4554; Domain of unknown function (DUF4554)

    2. XM_011248637.4 → XP_011246939.1  type 2 DNA topoisomerase 6 subunit B-like isoform X4

      UniProtKB/TrEMBL
      A0A182DWE7
      Conserved Domains (1) summary
      pfam15091
      Location:274 → 677
      DUF4554; Domain of unknown function (DUF4554)

    3. XM_011248636.4 → XP_011246938.1  type 2 DNA topoisomerase 6 subunit B-like isoform X3

      UniProtKB/TrEMBL
      A0A182DWE7
      Conserved Domains (1) summary
      pfam15091
      Location:274 → 681
      DUF4554; Domain of unknown function (DUF4554)

    4. XM_011248634.4 → XP_011246936.1  type 2 DNA topoisomerase 6 subunit B-like isoform X1

      UniProtKB/TrEMBL
      A0A182DWE7
      Related
      ENSMUSP00000136515.2, ENSMUST00000177696.8
      Conserved Domains (1) summary
      pfam15091
      Location:274 → 714
      DUF4554; Domain of unknown function (DUF4554)

    5. XM_036161617.1 → XP_036017510.1  type 2 DNA topoisomerase 6 subunit B-like isoform X6

      UniProtKB/TrEMBL
      A0A182DWE7
      Conserved Domains (1) summary
      pfam15091
      Location:274 → 658
      DUF4554; Domain of unknown function (DUF4554)

    6. XM_011248635.4 → XP_011246937.1  type 2 DNA topoisomerase 6 subunit B-like isoform X2

      UniProtKB/TrEMBL
      A0A182DWE7
      Conserved Domains (1) summary
      pfam15091
      Location:274 → 714
      DUF4554; Domain of unknown function (DUF4554)

    7. XM_011248639.4 → XP_011246941.1  type 2 DNA topoisomerase 6 subunit B-like isoform X7

      Conserved Domains (1) summary
      pfam15091
      Location:274 → 542
      DUF4554; Domain of unknown function (DUF4554)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    J3QMY9.2 GenPept UniProtKB/Swiss-Prot:J3QMY9

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