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    MIR4435-2HG MIR4435-2 host gene [ Homo sapiens (human) ]

    Gene ID: 541471, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MIR4435-2HGprovided by HGNC
    Official Full Name
    MIR4435-2 host geneprovided by HGNC
    Primary source
    HGNC:HGNC:35163
    See related
    Ensembl:ENSG00000172965 MIM:617144; AllianceGenome:HGNC:35163
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AGD2; MORRBID; LINC00978; MIR4435-1HG; lncRNA-AWPPH
    Expression
    Ubiquitous expression in appendix (RPKM 2.9), placenta (RPKM 2.8) and 24 other tissues See more
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    Genomic context

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    See MIR4435-2HG in Genome Data Viewer
    Location:
    2q13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (111195866..111495161, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (111618930..111920924, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111953443..112252738, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11865 Neighboring gene Sharpr-MPRA regulatory region 8028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11866 Neighboring gene BCL2 like 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111923374-111923874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16384 Neighboring gene uncharacterized LOC124907868 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11867 Neighboring gene Sharpr-MPRA regulatory region 6991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16385 Neighboring gene periaxin-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:112019862-112020362 Neighboring gene uncharacterized LOC101927283 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:112059022-112059522 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:112062300-112062800 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:112062801-112063301 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:112068229-112068736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:112067720-112068228 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:112074438-112074970 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:112077463-112078099 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:112078100-112078735 Neighboring gene ribosomal protein S14 pseudogene 4 Neighboring gene microRNA 4435-2 Neighboring gene platelet activating factor acetylhydrolase 1b regulatory subunit 1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:112193024-112193588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:112193589-112194153 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:112211190-112211923 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:112210455-112211189 Neighboring gene uncharacterized LOC124906065 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:112244635-112245487 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:112252044-112253243 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:112289353-112289852 Neighboring gene uncharacterized LOC124906066 Neighboring gene NANOG hESC enhancer GRCh37_chr2:112290355-112290856 Neighboring gene serous ovarian cancer associated RNA Neighboring gene DBF4 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The long non-coding RNA AK001796 contributes to tumor growth via regulating expression of p53 in esophageal squamous cell carcinoma. Liu B, et al. Cancer Cell Int, 2018. PMID 29568233, Free PMC Article
    2. LncRNA MIR4435-2HG is a potential early diagnostic marker for ovarian carcinoma. Gong J, et al. Acta Biochim Biophys Sin (Shanghai), 2019 Sep 6. PMID 31435668
    3. LncRNA MIR4435-2HG targets desmoplakin and promotes growth and metastasis of gastric cancer by activating Wnt/β-catenin signaling. Wang H, et al. Aging (Albany NY), 2019 Sep 4. PMID 31484163, Free PMC Article
    4. Integrative analysis of DNA methylation and gene expression profiles identifies MIR4435-2HG as an oncogenic lncRNA for glioma progression. Li Z, et al. Gene, 2019 Oct 5. PMID 31357021
    5. Fumarate induces LncRNA-MIR4435-2HG to regulate glutamine metabolism remodeling and promote the development of FH-deficient renal cell carcinoma. Zhu L, et al. Cell Death Dis, 2024 Feb 19. PMID 38374146, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fumarate induces LncRNA-MIR4435-2HG to regulate glutamine metabolism remodeling and promote the development of FH-deficient renal cell carcinoma.
      Title: Fumarate induces LncRNA-MIR4435-2HG to regulate glutamine metabolism remodeling and promote the development of FH-deficient renal cell carcinoma.
    2. M2 Macrophage-Derived Exosomal lncRNA MIR4435-2HG Promotes Progression of Infantile Hemangiomas by Targeting HNRNPA1.
      Title: M2 Macrophage-Derived Exosomal lncRNA MIR4435-2HG Promotes Progression of Infantile Hemangiomas by Targeting HNRNPA1.
    3. LncRNA MIR4435-2HG drives cancer progression by modulating cell cycle regulators and mTOR signaling in stroma-enriched subtypes of urothelial carcinoma of the bladder.
      Title: LncRNA MIR4435-2HG drives cancer progression by modulating cell cycle regulators and mTOR signaling in stroma-enriched subtypes of urothelial carcinoma of the bladder.
    4. LINC00978 regulates metabolic rewiring to promote the malignancy of glioblastoma through AKR1B1.
      Title: LINC00978 regulates metabolic rewiring to promote the malignancy of glioblastoma through AKR1B1.
    5. Long-chain Non-coding RNA MIR4435-2HG Expression Correlates With Size of Intestinal Polyps in Children and With Metastasis of Colon Cancer.
      Title: Long-chain Non-coding RNA MIR4435-2HG Expression Correlates With Size of Intestinal Polyps in Children and With Metastasis of Colon Cancer.
    6. LncRNA AWPPH is downregulated in osteoporosis and regulates type I collagen alpha1 and alpha2 ratio.
      Title: LncRNA AWPPH is downregulated in osteoporosis and regulates type I collagen α1 and α2 ratio.
    7. MIR4435-2HG: A Tumor-associated Long Non-coding RNA.
      Title: MIR4435-2HG: A Tumor-associated Long Non-coding RNA.
    8. Long Noncoding RNA MIR4435-2HG Suppresses Colorectal Cancer Initiation and Progression By Reprogramming Neutrophils.
      Title: Long Noncoding RNA MIR4435-2HG Suppresses Colorectal Cancer Initiation and Progression By Reprogramming Neutrophils.
    9. Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder Cancer.
      Title: Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder Cancer.
    10. MIR4435-2HG Is a Potential Pan-Cancer Biomarker for Diagnosis and Prognosis.
      Title: MIR4435-2HG Is a Potential Pan-Cancer Biomarker for Diagnosis and Prognosis.
    Submit: New GeneRIF Correction See all GeneRIFs (53)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • MIR4435-1 host gene (non-protein coding)
    • adipogenesis down-regulated transcript 2
    • lncRNA associated with poor prognosis of HCC
    • long intergenic non-protein coding RNA 978
    • myeloid RNA regulator of Bim-induced death

    Clone Names

    • FLJ10934, AC068491.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_015395.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC017002, AC068491, AC108463
      Related
      ENST00000666144.1

    2. NR_024373.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' end and is much shorter than variant 1.
      Source sequence(s)
      BC014776, DA316588
      Related
      ENST00000409569.3

    3. NR_136161.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108463, BQ026171, BX647931, DA316588
      Related
      ENST00000439362.6

    4. NR_136162.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC017002, AC068491, AC096670, AC108463
      Related
      ENST00000667670.1

    5. NR_136163.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC017002, AC068491, AC096670, AC108463
      Related
      ENST00000661559.1

    6. NR_136164.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC017002, AC068491, AC096670, AC108463
      Related
      ENST00000727422.1

    7. NR_136165.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AB485977, AC108463, DA316588
      Related
      ENST00000659458.1

    8. NR_136166.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC017002, AC068491, AC108463
      Related
      ENST00000659933.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      111195866..111495161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      111618930..111920924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013744.1: Suppressed sequence

      Description
      NM_001013744.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version

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