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    KIAA0408 KIAA0408 [ Homo sapiens (human) ]

    Gene ID: 9729, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KIAA0408provided by HGNC
    Official Full Name
    KIAA0408provided by HGNC
    Primary source
    HGNC:HGNC:21636
    See related
    Ensembl:ENSG00000189367 MIM:619236; AllianceGenome:HGNC:21636
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in brain (RPKM 13.3), fat (RPKM 8.5) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KIAA0408 in Genome Data Viewer
    Location:
    6q22.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (127438406..127459389, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (128627332..128648316, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (127759551..127780534, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene cornichon family member 4 pseudogene Neighboring gene SOGA3-KIAA0408 readthrough Neighboring gene ribosomal protein L17 pseudogene 23 Neighboring gene uncharacterized LOC124901399 Neighboring gene Sharpr-MPRA regulatory region 7566 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:127802337-127803536 Neighboring gene MTCL family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25041 Neighboring gene uncharacterized LOC107986642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:127835952-127836476

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. Ishikawa K, et al. DNA Res, 1997 Oct 31. PMID 9455477
    2. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Camargo LM, et al. Mol Psychiatry, 2007 Jan. PMID 17043677
    3. A comprehensive resource of interacting protein regions for refining human transcription factor networks. Miyamoto-Sato E, et al. PLoS One, 2010 Feb 24. PMID 20195357, Free PMC Article
    4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. Yeung ML, et al. J Biol Chem, 2009 Jul 17. PMID 19460752, Free PMC Article
    5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Butland SL, et al. Hum Mol Genet, 2014 Aug 1. PMID 24705354, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of uncharacterized protein KIAA0408 by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough SOGA3-KIAA0408

    Readthrough gene: SOGA3-KIAA0408, Included gene: MTCL3

    Homology

    Clone Names

    • FLJ43995

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein KIAA0408

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014702.5 → NP_055517.3  uncharacterized protein KIAA0408

      See identical proteins and their annotated locations for NP_055517.3

      Status: VALIDATED

      Source sequence(s)
      AK125983, AL096711, AL596809
      Consensus CDS
      CCDS34531.1
      UniProtKB/Swiss-Prot
      B3KRE5, E1P573, O43158, Q5TF20, Q6ZU52, Q7L2M2
      Related
      ENSP00000435150.2, ENST00000483725.8
      Conserved Domains (1) summary
      pfam14818
      Location:1 → 139
      DUF4482; Domain of unknown function (DUF4482)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      127438406..127459389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      128627332..128648316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZU52.1 GenPept UniProtKB/Swiss-Prot:Q6ZU52

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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