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    MAP3K19 mitogen-activated protein kinase kinase kinase 19 [ Homo sapiens (human) ]

    Gene ID: 80122, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MAP3K19provided by HGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 19provided by HGNC
    Primary source
    HGNC:HGNC:26249
    See related
    Ensembl:ENSG00000176601 AllianceGenome:HGNC:26249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RCK; YSK4
    Summary
    Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and protein serine kinase activity. Predicted to be involved in chromatin remodeling; intracellular signal transduction; and protein phosphorylation. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 2.7), lung (RPKM 0.8) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See MAP3K19 in Genome Data Viewer
    Location:
    2q21.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (134964491..135047447, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (135404909..135487908, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (135722061..135805017, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene aminocarboxymuconate semialdehyde decarboxylase Neighboring gene CCNT2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:135675361-135676034 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16569 Neighboring gene cyclin T2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:135732781-135733282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:135733283-135733782 Neighboring gene MPRA-validated peak3873 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16570 Neighboring gene small nucleolar RNA U13 Neighboring gene RAB3 GTPase activating protein catalytic subunit 1 Neighboring gene HNF4 motif-containing MPRA enhancer 203 Neighboring gene small nucleolar RNA, H/ACA box 40B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells. Hoang VT, et al. J Biol Chem, 2020 Jun 19. PMID 32358059, Free PMC Article
    2. MAP3K19 Is Overexpressed in COPD and Is a Central Mediator of Cigarette Smoke-Induced Pulmonary Inflammation and Lower Airway Destruction. Boehme SA, et al. PLoS One, 2016. PMID 27935962, Free PMC Article
    3. MAP3K19 Is a Novel Regulator of TGF-β Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis. Boehme SA, et al. PLoS One, 2016. PMID 27144281, Free PMC Article
    4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Butland SL, et al. Hum Mol Genet, 2014 Aug 1. PMID 24705354, Free PMC Article
    5. Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability. Silva LE, et al. J Proteome Res, 2019 Oct 4. PMID 31478661

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells.
      Title: The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells.
    2. Mitogen-activated protein kinase kinase kinase 19 (MAP3K19) is overexpressed in the lungs of chronic obstructive pulmonary disease (COPD) patients.
      Title: MAP3K19 Is Overexpressed in COPD and Is a Central Mediator of Cigarette Smoke-Induced Pulmonary Inflammation and Lower Airway Destruction.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23074

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 19
    Names
    SPS1/STE20-related protein kinase YSK4
    YSK4 Sps1/Ste20-related kinase homolog
    regulated in COPD kinase
    regulated in COPD, protein kinase
    yeast Sps1/Ste20-related kinase 4
    NP_001018054.1
    NP_001018056.1
    NP_001018057.1
    NP_001269812.1
    NP_001308106.1
    NP_001387367.1
    NP_079328.3
    XP_011510193.1
    XP_011510198.1
    XP_011510199.1
    XP_016860493.1
    XP_016860494.1
    XP_016860495.1
    XP_016860496.1
    XP_047301873.1
    XP_054200002.1
    XP_054200003.1
    XP_054200004.1
    XP_054200005.1
    XP_054200006.1
    XP_054200007.1
    XP_054200008.1
    XP_054200009.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018044.3 → NP_001018054.1  mitogen-activated protein kinase kinase kinase 19 isoform 3

      See identical proteins and their annotated locations for NP_001018054.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC016725, AY574902, BU676900
      Consensus CDS
      CCDS63020.1
      UniProtKB/Swiss-Prot
      Q56UN5
      Related
      ENSP00000351140.4, ENST00000358371.9
      Conserved Domains (2) summary
      smart00220
      Location:948 → 1211
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06631
      Location:946 → 1211
      STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

    2. NM_001018046.3 → NP_001018056.1  mitogen-activated protein kinase kinase kinase 19 isoform 2

      See identical proteins and their annotated locations for NP_001018056.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC016725, AY574904, BU676900
      Consensus CDS
      CCDS33293.1
      UniProtKB/Swiss-Prot
      Q56UN5
      Related
      ENSP00000365004.3, ENST00000375844.7
      Conserved Domains (2) summary
      smart00220
      Location:243 → 506
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06631
      Location:241 → 506
      STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

    3. NM_001018047.3 → NP_001018057.1  mitogen-activated protein kinase kinase kinase 19 isoform 4

      See identical proteins and their annotated locations for NP_001018057.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, and uses two alternate splice sites that result in the loss of an in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC016725, AY574905, BU676900
      Consensus CDS
      CCDS63022.1
      UniProtKB/Swiss-Prot
      Q56UN5
      Related
      ENSP00000376650.3, ENST00000392918.7
      Conserved Domains (2) summary
      smart00220
      Location:227 → 458
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:246 → 458
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001282883.2 → NP_001269812.1  mitogen-activated protein kinase kinase kinase 19 isoform 5

      See identical proteins and their annotated locations for NP_001269812.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two alternate exons that result in the loss of an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC016725, AC020602, BC144555, BU676900
      Consensus CDS
      CCDS63021.1
      UniProtKB/Swiss-Prot
      Q56UN5
      Related
      ENSP00000376649.3, ENST00000392917.8
      Conserved Domains (2) summary
      smart00220
      Location:206 → 456
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06631
      Location:206 → 456
      STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

    5. NM_001321177.2 → NP_001308106.1  mitogen-activated protein kinase kinase kinase 19 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC016725, AK122935, BC034417, BC137277
      UniProtKB/Swiss-Prot
      Q56UN5
      Related
      ENST00000638025.2
      Conserved Domains (1) summary
      cl21453
      Location:1076 → 1092
      PKc_like; Protein Kinases, catalytic domain

    6. NM_001400438.1 → NP_001387367.1  mitogen-activated protein kinase kinase kinase 19 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC016725, AC020602
      Consensus CDS
      CCDS2176.2
      UniProtKB/Swiss-Prot
      B2RP57, B7ZMH9, E2QRE3, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q56UN5, Q8N4E9, Q9H5T2

    7. NM_025052.5 → NP_079328.3  mitogen-activated protein kinase kinase kinase 19 isoform 1

      See identical proteins and their annotated locations for NP_079328.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC016725, AC020602
      Consensus CDS
      CCDS2176.2
      UniProtKB/Swiss-Prot
      B2RP57, B7ZMH9, E2QRE3, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q56UN5, Q8N4E9, Q9H5T2
      Related
      ENSP00000376647.2, ENST00000392915.7
      Conserved Domains (2) summary
      smart00220
      Location:1061 → 1324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06631
      Location:1059 → 1324
      STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      134964491..135047447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005005.3 → XP_016860494.1  mitogen-activated protein kinase kinase kinase 19 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:1033 → 1296
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06631
      Location:1031 → 1296
      STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

    2. XM_017005004.3 → XP_016860493.1  mitogen-activated protein kinase kinase kinase 19 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:1033 → 1296
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06631
      Location:1031 → 1296
      STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

    3. XM_017005006.3 → XP_016860495.1  mitogen-activated protein kinase kinase kinase 19 isoform X4

    4. XM_011511891.3 → XP_011510193.1  mitogen-activated protein kinase kinase kinase 19 isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:1078 → 1341
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06631
      Location:1076 → 1341
      STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

    5. XM_011511896.4 → XP_011510198.1  mitogen-activated protein kinase kinase kinase 19 isoform X3

      See identical proteins and their annotated locations for XP_011510198.1

      Conserved Domains (2) summary
      smart00220
      Location:966 → 1229
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06631
      Location:964 → 1229
      STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

    6. XM_011511897.4 → XP_011510199.1  mitogen-activated protein kinase kinase kinase 19 isoform X3

      See identical proteins and their annotated locations for XP_011510199.1

      Conserved Domains (2) summary
      smart00220
      Location:966 → 1229
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06631
      Location:964 → 1229
      STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

    7. XM_017005007.2 → XP_016860496.1  mitogen-activated protein kinase kinase kinase 19 isoform X6

      UniProtKB/TrEMBL
      A0A1B0GTF4

    8. XM_047445917.1 → XP_047301873.1  mitogen-activated protein kinase kinase kinase 19 isoform X5

      UniProtKB/TrEMBL
      A0A1B0GTF4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      135404909..135487908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344029.1 → XP_054200004.1  mitogen-activated protein kinase kinase kinase 19 isoform X2

    2. XM_054344028.1 → XP_054200003.1  mitogen-activated protein kinase kinase kinase 19 isoform X2

    3. XM_054344032.1 → XP_054200007.1  mitogen-activated protein kinase kinase kinase 19 isoform X4

    4. XM_054344027.1 → XP_054200002.1  mitogen-activated protein kinase kinase kinase 19 isoform X1

    5. XM_054344030.1 → XP_054200005.1  mitogen-activated protein kinase kinase kinase 19 isoform X3

    6. XM_054344031.1 → XP_054200006.1  mitogen-activated protein kinase kinase kinase 19 isoform X3

    7. XM_054344034.1 → XP_054200009.1  mitogen-activated protein kinase kinase kinase 19 isoform X6

      UniProtKB/TrEMBL
      A0A1B0GTF4

    8. XM_054344033.1 → XP_054200008.1  mitogen-activated protein kinase kinase kinase 19 isoform X5

      UniProtKB/TrEMBL
      A0A1B0GTF4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001018043.1: Suppressed sequence

      Description
      NM_001018043.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

    2. NM_001018045.1: Suppressed sequence

      Description
      NM_001018045.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q56UN5.1 GenPept UniProtKB/Swiss-Prot:Q56UN5

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