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    Ap2a2 adaptor-related protein complex 2, alpha 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 11772, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ap2a2provided by MGI
    Official Full Name
    adaptor-related protein complex 2, alpha 2 subunitprovided by MGI
    Primary source
    MGI:MGI:101920
    See related
    Ensembl:ENSMUSG00000002957 AllianceGenome:MGI:101920
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L25; Adtab; 2410074K14Rik
    Summary
    Enables disordered domain specific binding activity and protein kinase binding activity. Involved in clathrin-dependent endocytosis and synaptic vesicle endocytosis. Located in cytoplasmic vesicle. Part of AP-2 adaptor complex. Is expressed in brain. Orthologous to human AP2A2 (adaptor related protein complex 2 subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 33.9), duodenum adult (RPKM 33.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ap2a2 in Genome Data Viewer
    Location:
    7 F5; 7 86.94 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141142093..141212924)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141562180..141633011)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11377 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L Neighboring gene tetraspanin 4 Neighboring gene chitinase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_20492 Neighboring gene STARR-seq mESC enhancer starr_20493 Neighboring gene STARR-positive B cell enhancer ABC_E2855 Neighboring gene predicted gene, 16982 Neighboring gene microRNA 7063 Neighboring gene mucin 6, gastric Neighboring gene mucin 2 Neighboring gene mucin 5, subtypes A and C, tracheobronchial/gastric

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain. Owen DJ, et al. Cell, 1999 Jun 11. PMID 10380931
    2. 1H, 15N and 13C resonance assignments and 15N-1H residual dipolar couplings for the alpha-adaptin ear-domain. Denisov AY, et al. J Biomol NMR, 2004 Jul. PMID 15213459
    3. Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits. Gaidarov I, et al. J Cell Biol, 1999 Aug 23. PMID 10459011, Free PMC Article
    4. Tensile stress induces alpha-adaptin C production in mouse calvariae in an organ culture: possible involvement of endocytosis in mechanical stress-stimulated osteoblast differentiation. Shimomura J, et al. J Cell Physiol, 2003 Jun. PMID 12704659
    5. The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated Endocytosis to Prevent Plasma Membrane Damage during Listeria Infection. Chen C, et al. Cell Host Microbe, 2018 Jun 13. PMID 29902442, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study shows that IRF6 and AP2A interaction regulates epidermal development
      Title: IRF6 and AP2A Interaction Regulates Epidermal Development.
    2. Data indicate that dynamin, clathrin, adaptor protein complex-2 (AP2), and amphiphysin contribute to the depolarization-evoked entry in endocytosis.
      Title: Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons.
    3. PPARalpha regulates the mouse cardiac AP2alpha2 gene in both the control and transgenic mouse.
      Title: The adaptor-related protein complex 2, alpha 2 subunit (AP2α2) gene is a peroxisome proliferator-activated receptor cardiac target gene.
    4. the AP-2 complex is not associated with the endocytosed plasma membrane-associated clathrin
      Title: The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin.
    5. NMR structure of mouse alpha-adaptin ear-domain
      Title: 1H, 15N and 13C resonance assignments and 15N-1H residual dipolar couplings for the alpha-adaptin ear-domain.
    6. Tensile stress induces osteoblast differentiation possibly through the induction of alpha-adaptin C gene expression.
      Title: Tensile stress induces alpha-adaptin C production in mouse calvariae in an organ culture: possible involvement of endocytosis in mechanical stress-stimulated osteoblast differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in clathrin-dependent endocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular protein transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in postsynaptic neurotransmitter receptor internalization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of hematopoietic stem cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-2 adaptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of AP-2 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of AP-2 adaptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of membrane coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in secretory granule TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AP-2 complex subunit alpha-2
    Names
    100 kDa coated vesicle protein C
    adapter-related protein complex 2 alpha-2 subunit
    adapter-related protein complex 2 subunit alpha-2
    adaptor protein complex AP-2 subunit alpha-2
    adaptor protein complex AP-2, alpha 2 subunit
    adaptor-related protein complex 2 subunit alpha-2
    adaptor-related protein complex AP-2, alpha 2 subunit
    alpha-C adaptin
    alpha-adaptin C
    alpha2-adaptin
    clathrin assembly protein complex 2 alpha-C large chain
    plasma membrane adaptor HA2/AP2 adaptin alpha C subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357068.1 → NP_001343997.1  AP-2 complex subunit alpha-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102524, AC158224
      UniProtKB/TrEMBL
      Q6PEE6
      Conserved Domains (4) summary
      smart00809
      Location:717 → 820
      Alpha_adaptinC2; Adaptin C-terminal domain
      sd00044
      Location:332 → 355
      HEAT; HEAT repeat [structural motif]
      pfam02296
      Location:826 → 934
      Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
      pfam01602
      Location:29 → 591
      Adaptin_N; Adaptin N terminal region

    2. NM_007459.3 → NP_031485.3  AP-2 complex subunit alpha-2 isoform 2

      See identical proteins and their annotated locations for NP_031485.3

      Status: VALIDATED

      Source sequence(s)
      AK173054, BC058099, BY729047
      Consensus CDS
      CCDS40188.1
      UniProtKB/Swiss-Prot
      P17427, Q8C2J5, Q921V0
      UniProtKB/TrEMBL
      Q6PEE6
      Related
      ENSMUSP00000003038.9, ENSMUST00000003038.12
      Conserved Domains (4) summary
      smart00809
      Location:716 → 819
      Alpha_adaptinC2; Adaptin C-terminal domain
      sd00044
      Location:331 → 354
      HEAT; HEAT repeat [structural motif]
      pfam02296
      Location:825 → 933
      Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
      pfam01602
      Location:29 → 590
      Adaptin_N; Adaptin N terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141142093..141212924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17427.2 GenPept UniProtKB/Swiss-Prot:P17427

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