Eif4g2 eukaryotic translation initiation factor 4, gamma 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif4g2provided by MGI
Official Full Name: eukaryotic translation initiation factor 4, gamma 2provided by MGI
Primary source: MGI:MGI:109207
See related: Ensembl:ENSMUSG00000005610 AllianceGenome:MGI:109207
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p97; Nat1; DAP-5; Natm1; E130105L11Rik
Summary: Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 106.9), CNS E14 (RPKM 96.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 58.0 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (110667192..110682237, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (111067985..111083030, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.
Title: Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.
miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY TARGETING EIF4G2.
Title: miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY TARGETING EIF4G2.
Eukaryotic initiation factor 4 gamma 2 contributes to neuropathic pain through down-regulation of Kv1.2 and the mu opioid receptor in mouse primary sensory neurones.
Title: Eukaryotic initiation factor 4 gamma 2 contributes to neuropathic pain through down-regulation of Kv1.2 and the mu opioid receptor in mouse primary sensory neurones.
Findings suggest a new translational regulatory mechanism for DSCR1.4 expressions and a novel function of DAP5 as a positive regulator of DSCR1.4 mRNA translation induced in soma and axon of hippocampal neurons.
Title: DAP5 increases axonal outgrowth of hippocampal neurons by enhancing the cap-independent translation of DSCR1.4 mRNA.
analysis of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G
Title: Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor.
in vitro and in vivo studies in human show that translation starts at a non-AUG (GUG) codon. Suggest the same in mouse based on sequence conservation.
Title: A new translational regulator with homology to eukaryotic translation initiation factor 4G.
translation starts at a non-AUG translation initiation codon (GUG).
Title: cDNA cloning, expression analysis, and chromosomal localization of a gene with high homology to wheat eIF-(iso)4F and mammalian eIF-4G.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC314019P1 (e-PCR)
- UniSTS:272929

Eif4g2 (e-PCR), detects polymorphism
- UniSTS:474697

D11S3958 (e-PCR)
- UniSTS:153674

MARC_8851-8852:992359168:1 (e-PCR)
- UniSTS:269950

MARC_8853-8854:992364778:1 (e-PCR)
- UniSTS:269951

RH124947 (e-PCR)
- UniSTS:161769

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation factor activity, RNA binding	ISO Inferred from Sequence Orthology more info
enables translation factor activity, RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	ISO Inferred from Sequence Orthology more info
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in macromolecule biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translational initiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 4F complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 4F complex	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 4F complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eukaryotic translation initiation factor 4 gamma 2

Names: eIF-4-gamma 2; eIF-4G 2; eIF4G 2; novel APOBEC-1 target 1; translation repressor Nat1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040131.2 → NP_001035221.1 eukaryotic translation initiation factor 4 gamma 2 isoform 2

See identical proteins and their annotated locations for NP_001035221.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC150312, AC159206, AI874618, BC043034

Consensus CDS

CCDS40087.1

UniProtKB/TrEMBL

F7CBP1

Related

ENSMUSP00000125375.2, ENSMUST00000161051.8

Conserved Domains (4) summary

cd11559
Location:701 → 837

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

smart00544
Location:505 → 618

MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

pfam02854
Location:78 → 308

MIF4G; MIF4G domain

pfam11235
Location:412 → 509

Med25_SD1; Mediator complex subunit 25 synapsin 1
NM_013507.3 → NP_038535.2 eukaryotic translation initiation factor 4 gamma 2 isoform 1

See identical proteins and their annotated locations for NP_038535.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

AC150312, AI874618, BC043034

Consensus CDS

CCDS40088.1

UniProtKB/Swiss-Prot

P97867, Q0VGZ3, Q3UNC1, Q5XKD8, Q62448, Q6P1Z0, Q921U3

UniProtKB/TrEMBL

A0JNY7, G3XA17

Related

ENSMUSP00000124551.2, ENSMUST00000162415.9

Conserved Domains (3) summary

cd11559
Location:739 → 875

W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins

smart00544
Location:543 → 656

MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

pfam02854
Location:78 → 308

MIF4G; MIF4G domain