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    Il2ra interleukin 2 receptor, alpha chain [ Mus musculus (house mouse) ]

    Gene ID: 16184, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Il2raprovided by MGI
    Official Full Name
    interleukin 2 receptor, alpha chainprovided by MGI
    Primary source
    MGI:MGI:96549
    See related
    Ensembl:ENSMUSG00000026770 AllianceGenome:MGI:96549
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD25; Il2r; Ly-43
    Summary
    Enables interleukin-2 binding activity and interleukin-2 receptor activity. Acts upstream of or within several processes, including Notch signaling pathway; activation-induced cell death of T cells; and regulation of T cell proliferation. Located in external side of plasma membrane. Is expressed in bone marrow and yolk sac. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in thymus adult (RPKM 5.6), mammary gland adult (RPKM 1.1) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Il2ra in Genome Data Viewer
    Location:
    2 A1; 2 8.91 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (11647603..11698005)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (11642792..11693194)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03673 Neighboring gene RNA binding motif protein 17 Neighboring gene STARR-positive B cell enhancer ABC_E5883 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:11558884-11559067 Neighboring gene STARR-positive B cell enhancer ABC_E9504 Neighboring gene STARR-positive B cell enhancer ABC_E5884 Neighboring gene STARR-positive B cell enhancer ABC_E5885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:11577075-11577258 Neighboring gene STARR-seq mESC enhancer starr_03676 Neighboring gene predicted gene, 39760 Neighboring gene STARR-seq mESC enhancer starr_03677 Neighboring gene predicted gene, 39759 Neighboring gene interleukin 15 receptor, alpha chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements. Kim HP, et al. EMBO J, 2002 Jun 17. PMID 12065418, Free PMC Article
    2. Discovery of stimulation-responsive immune enhancers with CRISPR activation. Simeonov DR, et al. Nature, 2017 Sep 7. PMID 28854172, Free PMC Article
    3. Partial depletion of natural CD4⁺CD25⁺ regulatory T cells with anti-CD25 antibody does not alter the course of acute influenza A virus infection. Betts RJ, et al. PLoS One, 2011. PMID 22125630, Free PMC Article
    4. Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor. Van Parijs L, et al. J Immunol, 1997 Apr 15. PMID 9103438
    5. CD25+ T cells induce Helicobacter pylori-specific CD25- T-cell anergy but are not required to maintain persistent hyporesponsiveness. Stuller KA, et al. Eur J Immunol, 2008 Dec. PMID 19003932, Free PMC Article

    See all (318) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL-2Ralpha KO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Ralpha in lymphoid and non-lymphoid cells.
      Title: IL-2Rα KO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Rα in lymphoid and non-lymphoid cells.
    2. Conditional deletion of CD25 in the corneal epithelium reveals sex differences in barrier disruption.
      Title: Conditional deletion of CD25 in the corneal epithelium reveals sex differences in barrier disruption.
    3. Distinct use of super-enhancer elements controls cell type-specific CD25 transcription and function.
      Title: Distinct use of super-enhancer elements controls cell type-specific CD25 transcription and function.
    4. The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo.
      Title: The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo.
    5. Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25.
      Title: Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25.
    6. Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.
      Title: Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.
    7. Acute Lipopolysaccharide-Induced Inflammation Lowers IL-2R Signaling and the Proliferative Potential of Regulatory T Cells.
      Title: Acute Lipopolysaccharide-Induced Inflammation Lowers IL-2R Signaling and the Proliferative Potential of Regulatory T Cells.
    8. T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Ralpha-KO autoimmune mice.
      Title: T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice.
    9. CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation.
      Title: CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation.
    10. high-affinity T cells sustained IL-2R expression longer and expressed two novel Th cell differentiation regulators, Eef1e1 and Gbp2, to a higher level than low-affinity T cells.
      Title: TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.
    Submit: New GeneRIF Correction See all GeneRIFs (114)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130561

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables interleukin-2 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-2 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables interleukin-2 receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to interleukin-2 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-2 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within T cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within activation-induced cell death of T cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interleukin-2-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-2-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of lymphocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of lymphocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of CD4-positive, alpha-beta T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of T cell homeostatic proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of T cell tolerance induction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of T cell tolerance induction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-2 receptor subunit alpha
    Names
    IL-2 receptor subunit alpha
    IL-2-RA
    IL-2R alpha chain
    IL-2R subunit alpha
    IL2-RA
    p55 chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008367.3 → NP_032393.3  interleukin-2 receptor subunit alpha precursor

      See identical proteins and their annotated locations for NP_032393.3

      Status: VALIDATED

      Source sequence(s)
      AK037369, AL831794, BY200401
      Consensus CDS
      CCDS15685.1
      UniProtKB/Swiss-Prot
      P01590, Q61731
      UniProtKB/TrEMBL
      Q544I2, Q8C2H9
      Related
      ENSMUSP00000028111.5, ENSMUST00000028111.6
      Conserved Domains (1) summary
      cd00033
      Location:121 → 181
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      11647603..11698005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01590.1 GenPept UniProtKB/Swiss-Prot:P01590

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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