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    Cabyr calcium binding tyrosine phosphorylation regulated [ Mus musculus (house mouse) ]

    Gene ID: 71132, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Cabyrprovided by MGI
    Official Full Name
    calcium binding tyrosine phosphorylation regulatedprovided by MGI
    Primary source
    MGI:MGI:1918382
    See related
    Ensembl:ENSMUSG00000024430 AllianceGenome:MGI:1918382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CBP86; FSP-2; 1700016C01Rik; 4933421A18Rik
    Summary
    Enables calcium ion binding activity and protein domain specific binding activity. Located in cytoplasm and sperm flagellum. Used to study male infertility. Orthologous to human CABYR (calcium binding tyrosine phosphorylation regulated). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in testis adult (RPKM 63.2) and cortex adult (RPKM 3.8) See more
    Orthologs
    human all
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    Genomic context

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    See Cabyr in Genome Data Viewer
    Location:
    18 A1; 18 6.77 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (12874141..12888203)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (12740825..12755146)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 39C Neighboring gene predicted gene, 41668 Neighboring gene microRNA 1948 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene oxysterol binding protein-like 1A Neighboring gene predicted gene, 52343 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:12966807-12966996 Neighboring gene predicted gene, 36439

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CABYR is essential for fibrous sheath integrity and progressive motility in mouse spermatozoa. Young SA, et al. J Cell Sci, 2016 Dec 1. PMID 27802166
    2. Splicing in murine CABYR and its genomic structure. Sen B, et al. Gene, 2003 May 22. PMID 12801634
    3. Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice. Wang Y, et al. J Genet Genomics, 2024 Apr. PMID 37709195
    4. CABYR isoforms expressed in late steps of spermiogenesis bind with AKAPs and ropporin in mouse sperm fibrous sheath. Li YF, et al. Reprod Biol Endocrinol, 2010 Aug 23. PMID 20731842, Free PMC Article
    5. FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. Li YF, et al. J Biol Chem, 2007 Nov 23. PMID 17855365

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. it is the role of CABYR in the formation of the fibrous sheath that is essential for male fertility.
      Title: CABYR is essential for fibrous sheath integrity and progressive motility in mouse spermatozoa.
    2. CABYR expresses at the late stage of spermiogenesis and its isoforms oligomerize and bind with AKAPs and ropporin; which suggests that CABYR participates in the assembly of the fibrous sheath.
      Title: CABYR isoforms expressed in late steps of spermiogenesis bind with AKAPs and ropporin in mouse sperm fibrous sheath.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130217, MGC130218

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in sperm capacitation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm end piece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm fibrous sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm fibrous sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm fibrous sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcium-binding tyrosine phosphorylation-regulated protein
    Names
    calcium-binding protein 86
    calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)
    testis-specific calcium-binding protein CBP86

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042418.1 → NP_001035883.1  calcium-binding tyrosine phosphorylation-regulated protein isoform a

      See identical proteins and their annotated locations for NP_001035883.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' UTR, compared to variant 1. It encodes the same protein as variant 1 (isoform a).
      Source sequence(s)
      AF359385
      Consensus CDS
      CCDS37739.1
      UniProtKB/Swiss-Prot
      Q91Y41, Q91Y42, Q9D424
      Related
      ENSMUSP00000118330.2, ENSMUST00000150758.8
      Conserved Domains (1) summary
      cd12100
      Location:10 → 48
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

    2. NM_001042419.1 → NP_001035884.1  calcium-binding tyrosine phosphorylation-regulated protein isoform e

      See identical proteins and their annotated locations for NP_001035884.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region, compared to variant 1. The encoded isoform (e) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AF359384, BC107272
      Consensus CDS
      CCDS50224.1
      UniProtKB/TrEMBL
      A0A3Q4EGN8
      Related
      ENSMUSP00000113760.2, ENSMUST00000119108.8
      Conserved Domains (1) summary
      cd12100
      Location:10 → 48
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

    3. NM_001042420.1 → NP_001035885.1  calcium-binding tyrosine phosphorylation-regulated protein isoform a

      See identical proteins and their annotated locations for NP_001035885.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an exon in the 3' UTR, compared to variant 1. It encodes the same protein as variant 1 (isoform a).
      Source sequence(s)
      AK016856, BB017109
      Consensus CDS
      CCDS37739.1
      UniProtKB/Swiss-Prot
      Q91Y41, Q91Y42, Q9D424
      Related
      ENSMUSP00000111523.3, ENSMUST00000115857.9
      Conserved Domains (1) summary
      cd12100
      Location:10 → 48
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

    4. NM_027687.2 → NP_081963.1  calcium-binding tyrosine phosphorylation-regulated protein isoform a

      See identical proteins and their annotated locations for NP_081963.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AF359382
      Consensus CDS
      CCDS37739.1
      UniProtKB/Swiss-Prot
      Q91Y41, Q91Y42, Q9D424
      Related
      ENSMUSP00000140870.2, ENSMUST00000186263.2
      Conserved Domains (1) summary
      cd12100
      Location:10 → 48
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

    5. NM_181731.3 → NP_859420.2  calcium-binding tyrosine phosphorylation-regulated protein isoform c

      See identical proteins and their annotated locations for NP_859420.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AF359383, BC107272
      Consensus CDS
      CCDS50223.1
      UniProtKB/TrEMBL
      Q3KNH8
      Related
      ENSMUSP00000113131.2, ENSMUST00000121018.8
      Conserved Domains (1) summary
      cd12100
      Location:10 → 48
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      12874141..12888203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317979.3 → XP_017173468.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X1

      UniProtKB/Swiss-Prot
      Q91Y41, Q91Y42, Q9D424
      Conserved Domains (1) summary
      cd12100
      Location:10 → 48
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

    2. XM_036161276.1 → XP_036017169.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X2

      UniProtKB/TrEMBL
      Q3KNH8
      Conserved Domains (1) summary
      cd12100
      Location:10 → 48
      DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D424.1 GenPept UniProtKB/Swiss-Prot:Q9D424

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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