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    Uba6 ubiquitin-like modifier activating enzyme 6 [ Mus musculus (house mouse) ]

    Gene ID: 231380, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Uba6provided by MGI
    Official Full Name
    ubiquitin-like modifier activating enzyme 6provided by MGI
    Primary source
    MGI:MGI:1913894
    See related
    Ensembl:ENSMUSG00000035898 AllianceGenome:MGI:1913894
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E1-L2; Ube1l2; 4930542H01; 5730469D23Rik
    Summary
    Enables FAT10 activating enzyme activity and ubiquitin activating enzyme activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including dendritic spine development; learning; and limbic system development. Predicted to be active in cytoplasm. Is expressed in cerebral cortex and gonad. Orthologous to human UBA6 (ubiquitin like modifier activating enzyme 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta adult (RPKM 8.1), CNS E11.5 (RPKM 4.2) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Uba6 in Genome Data Viewer
    Location:
    5 E1; 5 43.56 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (86258579..86320602, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (86110720..86172743, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:86498237-86498420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:86500459-86500642 Neighboring gene STARR-positive B cell enhancer ABC_E3586 Neighboring gene predicted gene 2287 Neighboring gene STARR-positive B cell enhancer ABC_E2747 Neighboring gene signal transducing adaptor family member 1 Neighboring gene predicted gene, 24524 Neighboring gene STARR-seq mESC enhancer starr_13544 Neighboring gene STARR-positive B cell enhancer ABC_E10326 Neighboring gene gonadotropin releasing hormone receptor Neighboring gene transmembrane protease, serine 11c Neighboring gene predicted gene, 25473

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of UBA6 by inosine augments tumour immunogenicity and responses. Zhang L, et al. Nat Commun, 2022 Sep 15. PMID 36109526, Free PMC Article
    2. Impairment of social behavior and communication in mice lacking the Uba6-dependent ubiquitin activation system. Lee JY, et al. Behav Brain Res, 2015 Mar 15. PMID 25523030
    3. Early-stage paired housing improves social interaction in neuronal Uba6-deficient mice. Kim MJ, et al. Biochem Biophys Res Commun, 2019 Jun 25. PMID 31060776
    4. Ubiquitin Activating Enzyme UBA6 Regulates Th1 and Tc1 Cell Differentiation. Lee JY, et al. Cells, 2021 Dec 29. PMID 35011668, Free PMC Article
    5. Identification and expression of potential regulators of the mammalian mitotic-to-meiotic transition. Hogarth CA, et al. Biol Reprod, 2011 Jan. PMID 20826732, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of UBA6 by inosine augments tumour immunogenicity and responses.
      Title: Inhibition of UBA6 by inosine augments tumour immunogenicity and responses.
    2. Ubiquitin Activating Enzyme UBA6 Regulates Th1 and Tc1 Cell Differentiation.
      Title: Ubiquitin Activating Enzyme UBA6 Regulates Th1 and Tc1 Cell Differentiation.
    3. Early-stage paired housing improves social interaction in neuronal Uba6-deficient mice as a model of autism spectrum disorder.
      Title: Early-stage paired housing improves social interaction in neuronal Uba6-deficient mice.
    4. Uba6 and Use1 promote proteasomal turnover of Ube3a in mouse embryo fibroblasts (MEFs) and catalyze Ube3a ubiquitylation in vitro.
      Title: Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system.
    5. The identification of an E1-like protein, termed E1-L2, that activates both ubiquitin and another ubiquitin-like protein, FAT10, is reported.
      Title: E1-L2 activates both ubiquitin and FAT10.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAT10 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FAT10 activating enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables FAT10 activating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables thiosulfate sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin activating enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within amygdala development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-like modifier-activating enzyme 6
    Names
    ubiquitin-activating enzyme 6
    ubiquitin-activating enzyme E1-like 2
    ubiquitin-activating enzyme E1-like protein 2
    NP_766300.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172712.2 → NP_766300.1  ubiquitin-like modifier-activating enzyme 6

      See identical proteins and their annotated locations for NP_766300.1

      Status: PROVISIONAL

      Source sequence(s)
      BC063048
      Consensus CDS
      CCDS19378.1
      UniProtKB/Swiss-Prot
      Q8C7R4
      UniProtKB/TrEMBL
      D3Z061
      Related
      ENSMUSP00000035328.8, ENSMUST00000039373.14
      Conserved Domains (4) summary
      cd01490
      Location:462 → 1005
      Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      cd01491
      Location:43 → 432
      Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      TIGR01408
      Location:38 → 1046
      Ube1; ubiquitin-activating enzyme E1
      pfam16191
      Location:299 → 362
      E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      86258579..86320602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C7R4.1 GenPept UniProtKB/Swiss-Prot:Q8C7R4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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