Aard alanine and arginine rich domain containing protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aardprovided by MGI
Official Full Name: alanine and arginine rich domain containing proteinprovided by MGI
Primary source: MGI:MGI:2181621
See related: Ensembl:ENSMUSG00000068522 AllianceGenome:MGI:2181621
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A5D3
Summary: Acts upstream of or within response to testosterone. Is expressed in several structures, including brain; genitourinary system; gut; liver and biliary system; and respiratory system. Orthologous to human AARD (alanine and arginine rich domain containing protein). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in testis adult (RPKM 53.7), bladder adult (RPKM 26.2) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 C; 15 19.55 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (51903503..51909118)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (52040107..52045722)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of the present study indicate that Aard is a target of AR action in mouse Sertoli cells and suggest a novel finding by which the loss of AR function in Sertoli cells blocks spermatogenesis and results in male infertility.
Title: Alanine and arginine rich domain containing protein, Aard, is directly regulated by androgen receptor in mouse Sertoli cells.
Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation.
Title: Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Aard (e-PCR), detects polymorphism
- UniSTS:464651

AV328152 (e-PCR)
- UniSTS:180755

Aard (e-PCR), detects polymorphism
- UniSTS:256995

Aard (e-PCR), detects polymorphism
- UniSTS:498922

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within response to testosterone	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: alanine and arginine-rich domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.