Bnc2 basonuclin zinc finger protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bnc2provided by MGI
Official Full Name: basonuclin zinc finger protein 2provided by MGI
Primary source: MGI:MGI:2443805
See related: Ensembl:ENSMUSG00000028487 AllianceGenome:MGI:2443805
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5031434M05Rik; 8430420F16Rik
Summary: Enables rDNA binding activity. Acts upstream of or within several processes, including endochondral bone growth; roof of mouth development; and tongue development. Located in chromatin and nucleus. Is expressed in several structures, including genitourinary system; jaw; nervous system; nose; and skin. Orthologous to human BNC2 (basonuclin zinc finger protein 2). [provided by Alliance of Genome Resources, Oct 2024]
Annotation information: Annotation category: partial on reference assembly
Expression: Biased expression in limb E14.5 (RPKM 4.5), bladder adult (RPKM 2.8) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C3- C4; 4 39.76 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (84185041..84593236, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (84266804..84676029, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ-Bnc2 alleviates neuroinflammation in LPS-stimulated microglial cells to inhibit neuron cell apoptosis through regulating miR-497a-5p/HECTD1 axis.
Title: Circ-Bnc2 alleviates neuroinflammation in LPS-stimulated microglial cells to inhibit neuron cell apoptosis through regulating miR-497a-5p/HECTD1 axis.
BNC1 cannot substitute for BNC2.
Title: The importance of basonuclin 2 in adult mice and its relation to basonuclin 1.
BNC2 is a major regulator of male germ stem cells, which is required for repression of meiosis and mitosis in prospermatogonia, and for meiosis progression during spermatogenesis.
Title: The zinc-finger protein basonuclin 2 is required for proper mitotic arrest, prevention of premature meiotic initiation and meiotic progression in mouse male germ cells.
Bnc2(-/-) mice of both sexes displayed a high frequency of distal urethral defects; heterozygotes showed similar defects with reduced penetrance.
Title: Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development.
Results show that basonuclin 2 is essential for the multiplication of craniofacial mesenchymal cells during embryogenesis.
Title: Basonuclin 2 has a function in the multiplication of embryonic craniofacial mesenchymal cells and is orthologous to disco proteins.
the extreme conservation of the basonuclin 2 amino acid sequence across vertebrates suggests that basonuclin 2 serves an important function, presumably as a regulatory protein of DNA transcription
Title: Basonuclin 2: an extremely conserved homolog of the zinc finger protein basonuclin.
gene expression profiling; structural and functional similarities with Basonuclin 1 suggest that Basonuclin2 may play an analogous function in germ cells and skin keratinocytes
Title: Identification of Basonuclin2, a DNA-binding zinc-finger protein expressed in germ tissues and skin keratinocytes.
Data show that basonuclin (Bn)2 but not bn1 colocalizes with SC35 in nuclear speckles, and may have a function in nuclear processing of mRNA.
Title: Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables rDNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within endochondral bone growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesenchyme development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
NOT acts_upstream_of_or_within regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tongue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein basonuclin-2

Names: basonuclin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001369081.2 → NP_001356010.1 zinc finger protein basonuclin-2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL772137, AL772261, AL805919, BX004826

UniProtKB/Swiss-Prot

H3BIU0, Q6T3A4, Q8BMQ3

Conserved Domains (2) summary

sd00017
Location:1044 → 1065

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:842 → 863

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001369082.2 → NP_001356011.1 zinc finger protein basonuclin-2 isoform 3

Status: VALIDATED

Source sequence(s)

AL772137, AL772261, AL805919, BX004826

UniProtKB/TrEMBL

Q2TBA5

Conserved Domains (2) summary

sd00017
Location:977 → 998

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:775 → 796

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001369083.2 → NP_001356012.1 zinc finger protein basonuclin-2 isoform 4

Status: VALIDATED

Source sequence(s)

AL772137, AL772261, AL805919, BX004826

Consensus CDS

CCDS89773.1

UniProtKB/Swiss-Prot

H3BIU0, Q6T3A4, Q8BMQ3

UniProtKB/TrEMBL

H3BIU2

Related

ENSMUSP00000102816.3, ENSMUST00000107198.9

Conserved Domains (2) summary

sd00017
Location:1037 → 1058

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:835 → 856

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001369084.2 → NP_001356013.1 zinc finger protein basonuclin-2 isoform 5

Status: VALIDATED

Source sequence(s)

AL772137, AL772261, AL805919, BX004826

UniProtKB/TrEMBL

Q2TBA4, Q2TBA5

Conserved Domains (1) summary

sd00017
Location:959 → 980

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_172870.6 → NP_766458.3 zinc finger protein basonuclin-2 isoform 2

Status: VALIDATED

Source sequence(s)

AL772137, AL772261, AL805919, BX004826

Consensus CDS

CCDS18301.2

UniProtKB/TrEMBL

Q2TBA5

Related

ENSMUSP00000135375.2, ENSMUST00000176691.8

Conserved Domains (1) summary

sd00017
Location:970 → 991

ZF_C2H2; C2H2 Zn finger [structural motif]