Stard13 StAR related lipid transfer domain containing 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stard13provided by MGI
Official Full Name: StAR related lipid transfer domain containing 13provided by MGI
Primary source: MGI:MGI:2385331
See related: Ensembl:ENSMUSG00000016128 AllianceGenome:MGI:2385331
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DLC2; GT650
Summary: Predicted to enable GTPase activator activity. Acts upstream of or within negative regulation of sprouting angiogenesis. Predicted to be located in lipid droplet and mitochondrial membrane. Orthologous to human STARD13 (StAR related lipid transfer domain containing 13). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in lung adult (RPKM 12.8), bladder adult (RPKM 6.2) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G3; 5 89.82 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (150960975..151351780, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (151037515..151428200, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of DLC2 and RhoA/ROCK pathway in formalin induced inflammatory pain in mice.
Title: Role of DLC2 and RhoA/ROCK pathway in formalin induced inflammatory pain in mice.
Stard13 regulates insulin secretion in response to glucose via actin cytoskeleton remodeling.
Title: The RhoGAP Stard13 controls insulin secretion through F-actin remodeling.
Results indicate that Stard13 acts as a metastasis suppressor rather than a tumor suppressor gene, in Neu oncogene induced mammary tumorigenesis.
Title: In vivo evidence supporting a metastasis suppressor role for Stard13 (Dlc2) in ErbB2 (Neu) oncogene induced mouse mammary tumors.
role of miR-125b in pro-metastasis by targeting STARD13
Title: MicroRNA-125b induces metastasis by targeting STARD13 in MCF-7 and MDA-MB-231 breast cancer cells.
DLC2 plays a key role in pain modulation during inflammation by suppressing the activation of RhoA and ERK to prevent an exaggerated pain response
Title: The RhoA GTPase-activating protein DLC2 modulates RhoA activity and hyperalgesia to noxious thermal and inflammatory stimuli.
START-GAP2 is localized in focal adhesions through a "FAT (focal adhesion targeting)" region in the N-terminal half.
Title: START-GAP2/DLC2 is localized in focal adhesions via its N-terminal region.
Results suggest that DLC2 exhibits its tumor suppressor functions in vivo as a GAP specific for RhoA, exerting its effects in suppression of cytoskeleton reorganization, cell growth, cell migration, and transformation.
Title: Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
NOT acts_upstream_of_or_within angiogenesis involved in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endothelial cell migration	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within endothelial tube lumen extension	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: stAR-related lipid transfer protein 13

Names: START domain-containing protein 13; StAR-related lipid transfer (START) domain containing 13; serologically defined colon cancer antigen 13; serologically defined colon cancer antigen 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163493.2 → NP_001156965.1 stAR-related lipid transfer protein 13 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC109614, AC163219

Consensus CDS

CCDS51710.1

UniProtKB/TrEMBL

A0A2X0SFI9, F8WIY7

Related

ENSMUSP00000053232.9, ENSMUST00000062015.15

Conserved Domains (4) summary

cd09592
Location:57 → 120

SAM_DLC2; SAM domain of STARD13-like subfamily

smart00454
Location:61 → 120

SAM; Sterile alpha motif

cd04375
Location:676 → 893

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

cl14643
Location:920 → 1123

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
NM_001359985.2 → NP_001346914.1 stAR-related lipid transfer protein 13 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

AC109614, AC163219

UniProtKB/TrEMBL

A0A2X0SFI9

Conserved Domains (2) summary

cd04375
Location:481 → 698

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

cl14643
Location:725 → 928

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
NM_001424723.1 → NP_001411652.1 stAR-related lipid transfer protein 13 isoform 4

Status: VALIDATED

Source sequence(s)

AC109614, AC163219
NM_001424724.1 → NP_001411653.1 stAR-related lipid transfer protein 13 isoform 5

Status: VALIDATED

Source sequence(s)

AC109614, AC163219
NM_001424725.1 → NP_001411654.1 stAR-related lipid transfer protein 13 isoform 6

Status: VALIDATED

Source sequence(s)

AC109614, AC163219

UniProtKB/TrEMBL

A0A0J9YU82

Related

ENSMUSP00000144056.2, ENSMUST00000202111.4
NM_001424726.1 → NP_001411655.1 stAR-related lipid transfer protein 13 isoform 6

Status: VALIDATED

Source sequence(s)

AC109614, AC163219

UniProtKB/TrEMBL

A0A0J9YU82
NM_001424727.1 → NP_001411656.1 stAR-related lipid transfer protein 13 isoform 7

Status: VALIDATED

Source sequence(s)

AC109614, AC163219
NM_001424728.1 → NP_001411657.1 stAR-related lipid transfer protein 13 isoform 7

Status: VALIDATED

Source sequence(s)

AC109614, AC163219
NM_146258.3 → NP_666370.3 stAR-related lipid transfer protein 13 isoform 2

See identical proteins and their annotated locations for NP_666370.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, which results in a protein (isoform 2) that is 19 amino acids shorter than isoform 1.

Source sequence(s)

AC109614, AC163219

Consensus CDS

CCDS19890.1

UniProtKB/Swiss-Prot

E9PUB5, Q8K369, Q923Q2

UniProtKB/TrEMBL

A0A2X0SFI9

Related

ENSMUSP00000106109.3, ENSMUST00000110483.9

Conserved Domains (4) summary

cd09592
Location:57 → 120

SAM_DLC2; SAM domain of STARD13-like subfamily

smart00454
Location:61 → 120

SAM; Sterile alpha motif

cd04375
Location:657 → 874

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

cl14643
Location:901 → 1104

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

RNA

NR_153382.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC109614, AC163219

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

150960975..151351780 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504923.5 → XP_006504986.1 stAR-related lipid transfer protein 13 isoform X3

See identical proteins and their annotated locations for XP_006504986.1

UniProtKB/TrEMBL

A0A2X0SFI9

Conserved Domains (2) summary

cd04375
Location:558 → 775

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

cl14643
Location:802 → 1005

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_006504918.5 → XP_006504981.1 stAR-related lipid transfer protein 13 isoform X1

UniProtKB/TrEMBL

A0A2X0SFI9

Conserved Domains (3) summary

cd09592
Location:42 → 105

SAM_DLC2; SAM domain of STARD13-like subfamily

cd04375
Location:661 → 878

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

cl14643
Location:905 → 1108

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_006504921.3 → XP_006504984.1 stAR-related lipid transfer protein 13 isoform X3

See identical proteins and their annotated locations for XP_006504984.1

UniProtKB/TrEMBL

A0A2X0SFI9

Conserved Domains (2) summary

cd04375
Location:558 → 775

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

cl14643
Location:802 → 1005

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_036165136.1 → XP_036021029.1 stAR-related lipid transfer protein 13 isoform X5

UniProtKB/TrEMBL

A0A0J9YU82, A0A2X0SFI9

Conserved Domains (2) summary

cd04375
Location:539 → 756

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

cl14643
Location:783 → 986

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_006504922.5 → XP_006504985.1 stAR-related lipid transfer protein 13 isoform X3

See identical proteins and their annotated locations for XP_006504985.1

UniProtKB/TrEMBL

A0A2X0SFI9

Conserved Domains (2) summary

cd04375
Location:558 → 775

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

cl14643
Location:802 → 1005

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_036165133.1 → XP_036021026.1 stAR-related lipid transfer protein 13 isoform X4

UniProtKB/TrEMBL

A0A2X0SFI9

Conserved Domains (2) summary

cd04375
Location:550 → 767

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

cl14643
Location:794 → 997

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily