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    Mettl2 methyltransferase 2, methylcytidine [ Mus musculus (house mouse) ]

    Gene ID: 52686, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mettl2provided by MGI
    Official Full Name
    methyltransferase 2, methylcytidineprovided by MGI
    Primary source
    MGI:MGI:1289171
    See related
    Ensembl:ENSMUSG00000020691 AllianceGenome:MGI:1289171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    METL; PSENIP1; D11Ertd768e; 2810438F06Rik; C130031G21Rik
    Summary
    Enables tRNA (cytidine-3-)-methyltransferase activity. Involved in tRNA methylation. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; heart; respiratory system; and sensory organ. Orthologous to several human genes including METTL2A (methyltransferase 2A, tRNA N3-cytidine). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.6), limb E14.5 (RPKM 6.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mettl2 in Genome Data Viewer
    Location:
    11 E1; 11 68.61 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105017251..105031972)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (105126425..105141146)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 3 Neighboring gene STARR-seq mESC enhancer starr_30901 Neighboring gene microtubule-associated protein pseudogene Neighboring gene predicted gene, 25362 Neighboring gene STARR-positive B cell enhancer ABC_E7076 Neighboring gene RIKEN cDNA 1700052K11 gene Neighboring gene STARR-positive B cell enhancer ABC_E8463 Neighboring gene predicted gene 11620 Neighboring gene tousled-like kinase 2 (Arabidopsis)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Three distinct 3-methylcytidine (m(3)C) methyltransferases modify tRNA and mRNA in mice and humans. Xu L, et al. J Biol Chem, 2017 Sep 1. PMID 28655767, Free PMC Article
    2. Unravelling the complex genetics of cleft lip in the mouse model. Juriloff DM, et al. Mamm Genome, 2001 Jun. PMID 11353389
    3. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082
    4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (4) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107608

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables tRNA (cytidine) methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA (cytidine) methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA (cytidine-3-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA (cytidine-3-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA (cytidine-3-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA N(3)-methylcytidine methyltransferase METTL2
    Names
    methyltransferase like 2
    methyltransferase-like protein 2
    NP_766155.3
    XP_006533777.1
    XP_006533778.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172567.3 → NP_766155.3  tRNA N(3)-methylcytidine methyltransferase METTL2

      See identical proteins and their annotated locations for NP_766155.3

      Status: VALIDATED

      Source sequence(s)
      AK048040, AL627235, BB671561
      Consensus CDS
      CCDS25538.1
      UniProtKB/Swiss-Prot
      Q3U5T7, Q5EBH8, Q8BMK1, Q8BXC2
      Related
      ENSMUSP00000021030.8, ENSMUST00000021030.8
      Conserved Domains (1) summary
      pfam08242
      Location:178 → 280
      Methyltransf_12; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      105017251..105031972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533714.2 → XP_006533777.1  tRNA N(3)-methylcytidine methyltransferase METTL2 isoform X1

      Conserved Domains (1) summary
      pfam08242
      Location:178 → 280
      Methyltransf_12; Methyltransferase domain

    2. XM_006533715.3 → XP_006533778.1  tRNA N(3)-methylcytidine methyltransferase METTL2 isoform X2

      Conserved Domains (1) summary
      pfam08242
      Location:178 → 280
      Methyltransf_12; Methyltransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMK1.2 GenPept UniProtKB/Swiss-Prot:Q8BMK1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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