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    Rnf6 ring finger protein 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304271, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rnf6provided by RGD
    Official Full Name
    ring finger protein 6provided by RGD
    Primary source
    RGD:1306092
    See related
    EnsemblRapid:ENSRNOG00000000968 AllianceGenome:RGD:1306092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity; nuclear androgen receptor binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of DNA-templated transcription; protein polyubiquitination; and regulation of androgen receptor signaling pathway. Predicted to act upstream of or within negative regulation of axon extension. Predicted to be located in axon; cytoplasm; and nucleus. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma and squamous cell carcinoma. Orthologous to human RNF6 (ring finger protein 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 153.4), Muscle (RPKM 153.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf6 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (13929160..13940663)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (8816797..8826870)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (10574168..10583196)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095890 Neighboring gene histidine triad nucleotide binding protein 1 like 2 Neighboring gene cyclin-dependent kinase 8 Neighboring gene uncharacterized LOC120095930 Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats. Liu B, et al. Brain Behav, 2020 Dec. PMID 32955171, Free PMC Article
    2. Identification of somatic mutations of the RNF6 gene in human esophageal squamous cell carcinoma. Lo HS, et al. Cancer Res, 2002 Aug 1. PMID 12154016
    3. RNF6 facilitates metastasis and radioresistance in hepatocellular carcinoma through ubiquitination of FoxA1. Cai J, et al. Exp Cell Res, 2019 Jan 1. PMID 30496760
    4. Gene control in germinal differentiation: RNF6, a transcription regulatory protein in the mouse sertoli cell. Lopez P, et al. Mol Cell Biol, 2002 May. PMID 11971979, Free PMC Article
    5. Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. Xu K, et al. Cancer Cell, 2009 Apr 7. PMID 19345326, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats.
      Title: Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within negative regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K27-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K6-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF6
    Names
    ring finger protein (C3H2C3 type) 6
    NP_001100588.1
    XP_038945266.1
    XP_038945267.1
    XP_063127321.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107118.3 → NP_001100588.1  E3 ubiquitin-protein ligase RNF6

      See identical proteins and their annotated locations for NP_001100588.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A0U1RRV4, A6K1D2, A6K1D4
      Conserved Domains (2) summary
      cd00162
      Location:615 → 655
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      cl17238
      Location:613 → 657
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      13929160..13940663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271251.1 → XP_063127321.1  E3 ubiquitin-protein ligase RNF6 isoform X1

      UniProtKB/TrEMBL
      D3ZRG6

    2. XM_039089339.2 → XP_038945267.1  E3 ubiquitin-protein ligase RNF6 isoform X2

      UniProtKB/TrEMBL
      A0A0U1RRV4, A6K1D2, A6K1D4
      Conserved Domains (2) summary
      cd00162
      Location:615 → 655
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      cl17238
      Location:613 → 657
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_039089338.2 → XP_038945266.1  E3 ubiquitin-protein ligase RNF6 isoform X2

      UniProtKB/TrEMBL
      A0A0U1RRV4, A6K1D2, A6K1D4
      Related
      ENSRNOP00000075825.2, ENSRNOT00000092401.3
      Conserved Domains (2) summary
      cd00162
      Location:615 → 655
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      cl17238
      Location:613 → 657
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein Strain
    Heading Accession and Version

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