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    Tnik TRAF2 and NCK interacting kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294917, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Tnikprovided by RGD
    Official Full Name
    TRAF2 and NCK interacting kinaseprovided by RGD
    Primary source
    RGD:1561817
    See related
    EnsemblRapid:ENSRNOG00000012422 AllianceGenome:RGD:1561817
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561817
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of dendrite morphogenesis. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 54. Orthologous to human TNIK (TRAF2 and NCK interacting kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 138.2), Lung (RPKM 92.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnik in Genome Data Viewer
    Location:
    2q24
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (113112937..113511341)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (111184352..111587993)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (113984599..114391805)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100791 Neighboring gene uncharacterized LOC120100792 Neighboring gene uncharacterized LOC134485608 Neighboring gene uncharacterized LOC134485609 Neighboring gene solute carrier family 2 member 2 Neighboring gene eukaryotic translation initiation factor 5A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Association between gene expression profiles and clinical outcome of pemetrexed-based treatment in patients with advanced non-squamous non-small cell lung cancer: exploratory results from a phase II study. Fennell DA, et al. PLoS One, 2014. PMID 25250715, Free PMC Article
    2. Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer. Takahashi H, et al. BMC Cancer, 2015 Oct 24. PMID 26499327, Free PMC Article
    3. Nuclear expression of phosphorylated TRAF2- and NCK-interacting kinase in hepatocellular carcinoma is associated with poor prognosis. Jin J, et al. Pathol Res Pract, 2014 Oct. PMID 25160513
    4. TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function. Coba MP, et al. J Neurosci, 2012 Oct 3. PMID 23035106, Free PMC Article
    5. Mucin depleted foci, colonic preneoplastic lesions lacking Muc2, show up-regulation of Tlr2 but not bacterial infiltration. Femia AP, et al. PLoS One, 2012. PMID 22242189, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TNIK maintains levels of glutamate receptors and other key postsynaptic density (PSD) proteins at the synapse, with loss of TNIK protein or inhibition of TNIK activity causing rapid degradation of PSD constituents.
      Title: The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.
    2. Expression of MINK and TNIK in neurons is required for normal dendritic arborization and surface expression of AMPA receptors.
      Title: MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microvillus assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TRAF2 and NCK-interacting protein kinase
    NP_001099892.1
    XP_008759119.2
    XP_017446219.1
    XP_017446220.1
    XP_017446221.1
    XP_063137616.1
    XP_063137617.1
    XP_063137618.1
    XP_063137619.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106422.1 → NP_001099892.1  TRAF2 and NCK-interacting protein kinase

      See identical proteins and their annotated locations for NP_001099892.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473961
      UniProtKB/TrEMBL
      A0A8I5ZV95, A6IHI7
      Conserved Domains (3) summary
      smart00036
      Location:1034 → 1326
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      113112937..113511341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281546.1 → XP_063137616.1  TRAF2 and NCK-interacting protein kinase isoform X1

    2. XM_017590730.3 → XP_017446219.1  TRAF2 and NCK-interacting protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A0G2K490, A0A8I5ZV95
      Related
      ENSRNOP00000072950.1, ENSRNOT00000086399.3

    3. XM_017590731.3 → XP_017446220.1  TRAF2 and NCK-interacting protein kinase isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZV95, A0A8I6GLD8, A6IHI6
      Related
      ENSRNOP00000095929.1, ENSRNOT00000115354.2
      Conserved Domains (3) summary
      smart00036
      Location:1034 → 1332
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06637
      Location:18 → 313
      STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

    4. XM_063281547.1 → XP_063137617.1  TRAF2 and NCK-interacting protein kinase isoform X4

    5. XM_017590732.3 → XP_017446221.1  TRAF2 and NCK-interacting protein kinase isoform X5

      UniProtKB/TrEMBL
      A0A8I6GFX7

    6. XM_063281548.1 → XP_063137618.1  TRAF2 and NCK-interacting protein kinase isoform X6

    7. XM_008760897.4 → XP_008759119.2  TRAF2 and NCK-interacting protein kinase isoform X7

      UniProtKB/TrEMBL
      A0A8I6GFX7
      Related
      ENSRNOP00000080133.2, ENSRNOT00000106609.2

    8. XM_063281549.1 → XP_063137619.1  TRAF2 and NCK-interacting protein kinase isoform X8

    Nucleotide Protein Strain
    Heading Accession and Version

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