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    Adam19 ADAM metallopeptidase domain 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303068, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Adam19provided by RGD
    Official Full Name
    ADAM metallopeptidase domain 19provided by RGD
    Primary source
    RGD:1585017
    See related
    EnsemblRapid:ENSRNOG00000042980 AllianceGenome:RGD:1585017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sox30
    Summary
    Predicted to enable SH3 domain binding activity and metalloendopeptidase activity involved in amyloid precursor protein catabolic process. Predicted to be involved in several processes, including amyloid precursor protein catabolic process; membrane protein ectodomain proteolysis; and positive regulation of cell-cell adhesion mediated by cadherin. Predicted to act upstream of or within heart development. Predicted to be located in Golgi apparatus and nucleus. Orthologous to human ADAM19 (ADAM metallopeptidase domain 19). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 306.1), Thymus (RPKM 156.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adam19 in Genome Data Viewer
    Location:
    10q21
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (30992713..31084455)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (30491362..30583115)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (31146107..31240582)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120095083 Neighboring gene NIPA-like domain containing 4 Neighboring gene uncharacterized LOC134480683 Neighboring gene cytoplasmic FMR1 interacting protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dynamic change of Adamalysin 19 (ADAM19) in human placentas and its effects on cell invasion and adhesion in human trophoblastic cells. Zhao M, et al. Sci China C Life Sci, 2009 Aug. PMID 19727588
    2. Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta. Wei P, et al. Biochem Biophys Res Commun, 2001 Jan 26. PMID 11162584
    3. ADAMs: key components in EGFR signalling and development. Blobel CP. Nat Rev Mol Cell Biol, 2005 Jan. PMID 15688065
    4. Roles of Meltrin beta /ADAM19 in the processing of neuregulin. Shirakabe K, et al. J Biol Chem, 2001 Mar 23. PMID 11116142
    5. Meltrin beta (ADAM19) gene: cloning, mapping, and analysis of the regulatory region. Kurohara K, et al. Biochem Biophys Res Commun, 2000 Apr 13. PMID 10753657

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TGF-beta stimulation of renal cells results in a significant up-regulation of Adams 10, 17, 12, and 19
      Title: Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in placenta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 19
    Names
    SRY-box containing gene 30
    a disintegrin and metallopeptidase domain 19 (meltrin beta)
    a disintegrin and metalloproteinase domain 19 (meltrin beta)
    meltrin beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160228.1 → NP_001153700.1  disintegrin and metalloproteinase domain-containing protein 19 precursor

      See identical proteins and their annotated locations for NP_001153700.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5Y236, A6HDQ9, D3ZPM7
      Related
      ENSRNOP00000008184.6, ENSRNOT00000008184.8
      Conserved Domains (5) summary
      smart00050
      Location:440 → 500
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:502 → 650
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:211 → 407
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:211 → 409
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:62 → 162
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      30992713..31084455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268971.1 → XP_063125041.1  disintegrin and metalloproteinase domain-containing protein 19 isoform X2

    2. XM_039085916.2 → XP_038941844.1  disintegrin and metalloproteinase domain-containing protein 19 isoform X3

      Conserved Domains (3) summary
      pfam01421
      Location:211 → 409
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:45 → 163
      Pep_M12B_propep; Reprolysin family propeptide
      cl10507
      Location:440 → 460
      Disintegrin

    3. XM_039085915.2 → XP_038941843.1  disintegrin and metalloproteinase domain-containing protein 19 isoform X1

      UniProtKB/TrEMBL
      D3ZPM7
      Conserved Domains (4) summary
      smart00050
      Location:386 → 446
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:448 → 596
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:157 → 355
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:15 → 109
      Pep_M12B_propep; Reprolysin family propeptide

    4. XM_039085917.2 → XP_038941845.1  disintegrin and metalloproteinase domain-containing protein 19 isoform X4

      Conserved Domains (2) summary
      smart00608
      Location:34 → 182
      ACR; ADAM Cysteine-Rich Domain
      cl10507
      Location:1 → 32
      Disintegrin
    Nucleotide Protein Strain
    Heading Accession and Version

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