CCT8 chaperonin containing TCP1 subunit 8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CCT8provided by HGNC
Official Full Name: chaperonin containing TCP1 subunit 8provided by HGNC
Primary source: HGNC:HGNC:1623
See related: Ensembl:ENSG00000156261 MIM:617786; AllianceGenome:HGNC:1623
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Cctq; PRED71; D21S246; C21orf112
Summary: This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]
Expression: Ubiquitous expression in adrenal (RPKM 57.9), lymph node (RPKM 57.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 21q21.3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	21	NC_000021.9 (29056326..29073648, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	21	NC_060945.1 (27419768..27437088, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (30428647..30445969, complement)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study demonstrated that CCT8 expression is widely upregulated in esophageal squamous cell carcinoma (ESCC), and enhanced the migration and invasion of ESCC cells, indicating that ectopic CCT8 expression contributes to the highly aggressive nature of ESCC probably by increasing alpha-actin and beta-tubulin expression.
Title: Chaperonin-containing T‑complex protein 1 subunit 8 promotes cell migration and invasion in human esophageal squamous cell carcinoma by regulating α-actin and β-tubulin expression.
Ectopic expression of CCT8 also ameliorates the age-associated demise of proteostasis and corrects proteostatic deficiencies in worm models of Huntington's disease.
Title: Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan.
data suggest that the GRP94/CCT8/c-Jun/EMT signaling cascade might be a new therapeutic target for HCC
Title: Glucose-regulated protein 94 mediates metastasis by CCT8 and the JNK pathway in hepatocellular carcinoma.
showed that high CCT8 protein expression might be related to poor outcome of glioma
Title: Overexpression of CCT8 and its significance for tumor cell proliferation, migration and invasion in glioma.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 interacts with CCT8	PubMed
Pr55(Gag)	gag	Cellular biotinylated CCT8 chaperonin containing TCP1, subunit 8 (theta) protein is incorporated into HIV-1 Gag virus-like particles	PubMed
Vif	vif	HIV-1 Vif interacts with CCT8	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5S2639 (e-PCR)
- UniSTS:30222

AL033864 (e-PCR)
- UniSTS:93740

RH25243 (e-PCR)
- UniSTS:15704

SHGC-51868 (e-PCR)
- UniSTS:4214

D21S388 (e-PCR)
- UniSTS:147857

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables cadherin binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	IDA Inferred from Direct Assay more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IEA Inferred from Electronic Annotation more info
involved_in chaperone mediated protein folding independent of cofactor	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaperone-mediated protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization to Cajal body	HMP more info	PubMed
involved_in positive regulation of telomerase RNA localization to Cajal body	HMP more info	PubMed
acts_upstream_of positive regulation of telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in azurophil granule lumen	TAS Traceable Author Statement more info
located_in cell body	IEA Inferred from Electronic Annotation more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
part_of chaperonin-containing T-complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chaperonin-containing T-complex	IDA Inferred from Direct Assay more info	PubMed
part_of chaperonin-containing T-complex	IPI Inferred from Physical Interaction more info	PubMed
part_of chaperonin-containing T-complex	TAS Traceable Author Statement more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
located_in intermediate filament cytoskeleton	IDA Inferred from Direct Assay more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in secretory granule lumen	TAS Traceable Author Statement more info
part_of zona pellucida receptor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: T-complex protein 1 subunit theta

Names: CCT-theta; TCP-1-theta; chaperonin containing T-complex polypeptide 1 subunit 8; chaperonin containing TCP1, subunit 8 (theta); renal carcinoma antigen NY-REN-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282907.2 → NP_001269836.1 T-complex protein 1 subunit theta isoform 2

See identical proteins and their annotated locations for NP_001269836.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site and contains an alternate exon in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2 which has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK293705, BC072001, BP248736, DB301557, DC298601

Consensus CDS

CCDS68181.1

UniProtKB/TrEMBL

Q53HU0

Related

ENSP00000486921.1, ENST00000626972.2

Conserved Domains (1) summary

TIGR02346
Location:2 → 520

chap_CCT_theta; T-complex protein 1, theta subunit
NM_001282908.2 → NP_001269837.1 T-complex protein 1 subunit theta isoform 3

See identical proteins and their annotated locations for NP_001269837.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.

Source sequence(s)

BC012584, BP248736

UniProtKB/TrEMBL

Q53HU0, Q7Z759

Related

ENST00000470450.5

Conserved Domains (2) summary

pfam00118
Location:1 → 477

Cpn60_TCP1; TCP-1/cpn60 chaperonin family

cl02777
Location:1 → 488

chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...
NM_001282909.2 → NP_001269838.1 T-complex protein 1 subunit theta isoform 4

See identical proteins and their annotated locations for NP_001269838.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 4, which has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK298801, BC072001, DB301557

Consensus CDS

CCDS68180.1

UniProtKB/TrEMBL

Q53HU0

Related

ENSP00000442730.1, ENST00000540844.5

Conserved Domains (1) summary

cl02777
Location:5 → 466

chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...
NM_006585.4 → NP_006576.2 T-complex protein 1 subunit theta isoform 1

See identical proteins and their annotated locations for NP_006576.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BC072001

Consensus CDS

CCDS33528.1

UniProtKB/Swiss-Prot

A6NN54, B4DEM7, B4DQH4, P50990, Q4VBP8

UniProtKB/TrEMBL

Q53HU0

Related

ENSP00000286788.4, ENST00000286788.9

Conserved Domains (1) summary

TIGR02346
Location:10 → 539

chap_CCT_theta; T-complex protein 1, theta subunit