MIR185 microRNA 185 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR185provided by HGNC
Official Full Name: microRNA 185provided by HGNC
Primary source: HGNC:HGNC:31556
See related: Ensembl:ENSG00000208023 MIM:615576; miRBase:MI0000482; AllianceGenome:HGNC:31556
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN185; miR-185
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 22q11.21

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (20033139..20033220)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (20410752..20410833)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (20020662..20020743)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MKLN1-AS promotes pancreatic cancer progression as a crucial downstream mediator of HIF-1alpha through miR-185-5p/TEAD1 pathway.
Title: MKLN1-AS promotes pancreatic cancer progression as a crucial downstream mediator of HIF-1α through miR-185-5p/TEAD1 pathway.
THAP9-AS1 promotes nasopharyngeal carcinoma progression through targeted regulation of the miR-185-5p/SOX13 axis.
Title: THAP9-AS1 promotes nasopharyngeal carcinoma progression through targeted regulation of the miR-185-5p/SOX13 axis.
Urinary miR-185-5p is a biomarker of renal tubulointerstitial fibrosis in IgA nephropathy.
Title: Urinary miR-185-5p is a biomarker of renal tubulointerstitial fibrosis in IgA nephropathy.
[miR-185-5p alleviates the inflammatory response of acute gouty arthritis by inhibiting of IL-1beta].
Title: [miR-185-5p alleviates the inflammatory response of acute gouty arthritis by inhibiting of IL-1β].
The role of microRNA-185 in the pathogenesis of human diseases: A focus on cancer.
Title: The role of microRNA-185 in the pathogenesis of human diseases: A focus on cancer.
The lncRNA ADAMTS9-AS1/miR-185-5p/KAT7 ceRNA network inhibits cardiomyocyte hypertrophy in hypertrophic obstructive cardiomyopathy.
Title: The lncRNA ADAMTS9-AS1/miR-185-5p/KAT7 ceRNA network inhibits cardiomyocyte hypertrophy in hypertrophic obstructive cardiomyopathy.
Highly-expressed lncRNA FOXD2-AS1 in adipose mesenchymal stem cell derived exosomes affects HaCaT cells via regulating miR-185-5p/ROCK2 axis.
Title: Highly-expressed lncRNA FOXD2-AS1 in adipose mesenchymal stem cell derived exosomes affects HaCaT cells via regulating miR-185-5p/ROCK2 axis.
The miRNA-185-5p/STIM1 Axis Regulates the Invasiveness of Nasopharyngeal Carcinoma Cell Lines by Modulating EGFR Activation-Stimulated Switch from E- to N-Cadherin.
Title: The miRNA-185-5p/STIM1 Axis Regulates the Invasiveness of Nasopharyngeal Carcinoma Cell Lines by Modulating EGFR Activation-Stimulated Switch from E- to N-Cadherin.
LncRNA UCA1 promotes tumorigenesis of breast cancer via targeting MiR-185-5p.
Title: LncRNA UCA1 promotes tumorigenesis of breast cancer via targeting MiR-185-5p.
MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction.
Title: MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction.

Submit: New GeneRIF Correction See all GeneRIFs (137)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA base-pairing translational repressor activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA base-pairing translational repressor activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to cholesterol	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cholesterol homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated gene silencing by mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info
involved_in miRNA-mediated post-transcriptional gene silencing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of (R)-mevalonic acid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of negative regulation of B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of cholesterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of cholesterol biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of negative regulation of fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of high-density lipoprotein particle clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of low-density lipoprotein particle clearance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of low-density lipoprotein particle clearance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of negative regulation of receptor-mediated endocytosis involved in cholesterol transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of response to drug	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage derived foam cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular vesicle	HDA more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.