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    PAGE3 PAGE family member 3 [ Homo sapiens (human) ]

    Gene ID: 139793, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PAGE3provided by HGNC
    Official Full Name
    PAGE family member 3provided by HGNC
    Primary source
    HGNC:HGNC:4110
    See related
    Ensembl:ENSG00000204279 MIM:300739; AllianceGenome:HGNC:4110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT16.6; GAGED1; PAGE-3
    Summary
    This gene is a member of family of proteins that are expressed in a variety of tumors and in some fetal and reproductive tissues. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2015]
    Expression
    Restricted expression toward testis (RPKM 1.3) See more
    Orthologs
    all
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    Genomic context

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    See PAGE3 in Genome Data Viewer
    Location:
    Xp11.21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (55258415..55264916, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (54551564..54558062, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (55284848..55291349, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene X antigen family member 3-like Neighboring gene small nucleolar RNA, H/ACA box 109 Neighboring gene PAGE family member 5 Neighboring gene PAGE family member 5 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:55368751-55369252 Neighboring gene microRNA 4536-1 Neighboring gene microRNA 4536-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. Brinkmann U, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724777, Free PMC Article
    2. Genome-wide association study of smoking behaviours among Bangladeshi adults. Argos M, et al. J Med Genet, 2014 May. PMID 24665060, Free PMC Article
    3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of smoking behaviours among Bangladeshi adults.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    P antigen family member 3
    Names
    G antigen family D member 1
    G antigen, family D, 1
    P antigen family, member 3 (prostate associated)
    prostate-associated gene 3 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017195.2 RefSeqGene

      Range
      5000..11501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001017931.3 → NP_001017931.3  P antigen family member 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL158819
      Consensus CDS
      CCDS35307.1
      UniProtKB/Swiss-Prot
      A5D6Y1, Q5JUK9
      Related
      ENSP00000364089.1, ENST00000374951.6
      Conserved Domains (1) summary
      pfam05831
      Location:1 → 107
      GAGE; GAGE protein

    2. NM_001171252.2 → NP_001164723.2  P antigen family member 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL158819
      Consensus CDS
      CCDS35307.1
      UniProtKB/Swiss-Prot
      A5D6Y1, Q5JUK9
      Related
      ENSP00000429571.1, ENST00000519203.1
      Conserved Domains (1) summary
      pfam05831
      Location:1 → 107
      GAGE; GAGE protein

    3. NM_001303613.2 → NP_001290542.2  P antigen family member 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains multiple differences in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL158819
      Consensus CDS
      CCDS35307.1
      UniProtKB/Swiss-Prot
      A5D6Y1, Q5JUK9
      Conserved Domains (1) summary
      pfam05831
      Location:1 → 107
      GAGE; GAGE protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      55258415..55264916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029282.3 → XP_016884771.1  P antigen family member 3 isoform X1

      UniProtKB/Swiss-Prot
      A5D6Y1, Q5JUK9
      Conserved Domains (1) summary
      pfam05831
      Location:1 → 107
      GAGE; GAGE protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      54551564..54558062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326505.1 → XP_054182480.1  P antigen family member 3 isoform X1

      UniProtKB/Swiss-Prot
      A5D6Y1, Q5JUK9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JUK9.1 GenPept UniProtKB/Swiss-Prot:Q5JUK9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials