U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ACSL1 acyl-CoA synthetase long chain family member 1 [ Homo sapiens (human) ]

    Gene ID: 2180, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ACSL1provided by HGNC
    Official Full Name
    acyl-CoA synthetase long chain family member 1provided by HGNC
    Primary source
    HGNC:HGNC:3569
    See related
    Ensembl:ENSG00000151726 MIM:152425; AllianceGenome:HGNC:3569
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACS1; LACS; FACL1; FACL2; LACS1; LACS2
    Summary
    The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
    Expression
    Biased expression in fat (RPKM 357.3), liver (RPKM 217.4) and 10 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ACSL1 in Genome Data Viewer
    Location:
    4q35.1
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (184755595..184826594, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (188099036..188170021, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (185676749..185747122, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:185564061-185564639 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:185564640-185565217 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:185565519-185566150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15841 Neighboring gene caspase 3 Neighboring gene primase and DNA directed polymerase Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:185609328-185610527 Neighboring gene centromere protein U Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15842 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:185654690-185655556 Neighboring gene NANOG hESC enhancer GRCh37_chr4:185657064-185657583 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:185668497-185668998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22233 Neighboring gene NANOG hESC enhancer GRCh37_chr4:185729525-185730070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22239 Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22240 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15844 Neighboring gene uncharacterized LOC105377587 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:185747691-185748194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22243 Neighboring gene MIR3945 host gene Neighboring gene microRNA 3945 Neighboring gene PATRR4 recombination region Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:185814744-185815943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22244 Neighboring gene long intergenic non-protein coding RNA 1093

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression. Ghosh B, et al. Mol Cell Biochem, 1995 Oct 4. PMID 8584017
    2. Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1. Beatty A, et al. Nat Commun, 2021 Apr 14. PMID 33854057, Free PMC Article
    3. Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation. Ma Y, et al. Oncogene, 2021 Mar. PMID 33564069, Free PMC Article
    4. Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation. Zhang Q, et al. Oncogene, 2021 Jan. PMID 33082557
    5. TNF-α Induces a Pro-Inflammatory Phenotypic Shift in Monocytes through ACSL1: Relevance to Metabolic Inflammation. Al-Rashed F, et al. Cell Physiol Biochem, 2019. PMID 30845379

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ACSL1-Mediated Fatty Acid beta-Oxidation Enhances Metastasis and Proliferation in Endometrial Cancer.
      Title: ACSL1-Mediated Fatty Acid β-Oxidation Enhances Metastasis and Proliferation in Endometrial Cancer.
    2. ACSL1: A preliminary study that provides a new target for the treatment of renal fibrosis could bring new insights in diabetic kidney disease.
      Title: ACSL1: A preliminary study that provides a new target for the treatment of renal fibrosis could bring new insights in diabetic kidney disease.
    3. Fatty acids and inflammatory stimuli induce expression of long-chain acyl-CoA synthetase 1 to promote lipid remodeling in diabetic kidney disease.
      Title: Fatty acids and inflammatory stimuli induce expression of long-chain acyl-CoA synthetase 1 to promote lipid remodeling in diabetic kidney disease.
    4. RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
      Title: RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
    5. Identification of toll-like receptor 5 and acyl-CoA synthetase long chain family member 1 as hub genes are correlated with the severe forms of COVID-19 by Weighted gene co-expression network analysis.
      Title: Identification of toll-like receptor 5 and acyl-CoA synthetase long chain family member 1 as hub genes are correlated with the severe forms of COVID-19 by Weighted gene co-expression network analysis.
    6. FATP2 regulates non-small cell lung cancer by mediating lipid metabolism through ACSL1.
      Title: FATP2 regulates non-small cell lung cancer by mediating lipid metabolism through ACSL1.
    7. Common genetic basis of ALS patients and soccer players may contribute to disease risk.
      Title: Common genetic basis of ALS patients and soccer players may contribute to disease risk.
    8. Circular RNA circACSL1 aggravated myocardial inflammation and myocardial injury by sponging miR-8055 and regulating MAPK14 expression.
      Title: Circular RNA circACSL1 aggravated myocardial inflammation and myocardial injury by sponging miR-8055 and regulating MAPK14 expression.
    9. Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation.
      Title: Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation.
    10. Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1.
      Title: Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arachidonate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity TAS
    Traceable Author Statement
    more info
    		  
    enables oleoyl-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phytanate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pristanate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adiponectin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-chain fatty acid import into cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in long-chain fatty acid import into cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of long-chain fatty acid import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oleic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    long-chain-fatty-acid--CoA ligase 1
    Names
    LACS 1
    LACS 2
    acyl-CoA synthetase 1
    arachidonate--CoA ligase
    fatty-acid-Coenzyme A ligase, long-chain 1
    fatty-acid-Coenzyme A ligase, long-chain 2
    lignoceroyl-CoA synthase
    long-chain acyl-CoA synthetase 1
    long-chain acyl-CoA synthetase 2
    long-chain fatty acid-CoA ligase 2
    long-chain fatty-acid-coenzyme A ligase 1
    palmitoyl-CoA ligase 1
    palmitoyl-CoA ligase 2
    paltimoyl-CoA ligase 1
    phytanate--CoA ligase
    NP_001273637.1
    NP_001273639.1
    NP_001273640.1
    NP_001368806.1
    NP_001368807.1
    NP_001368808.1
    NP_001368809.1
    NP_001368810.1
    NP_001368811.1
    NP_001368812.1
    NP_001368813.1
    NP_001368814.1
    NP_001368815.1
    NP_001368816.1
    NP_001368817.1
    NP_001368818.1
    NP_001368819.1
    NP_001986.2
    XP_016863376.1
    XP_047305775.1
    XP_054205230.1
    XP_054205231.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286708.2 → NP_001273637.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      See identical proteins and their annotated locations for NP_001273637.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 6-12 all encode the same isoform (a).
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS3839.1
      UniProtKB/Swiss-Prot
      B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
      UniProtKB/TrEMBL
      A8K9T3
      Related
      ENSP00000425006.1, ENST00000504342.5
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    2. NM_001286710.2 → NP_001273639.1  long-chain-fatty-acid--CoA ligase 1 isoform b

      See identical proteins and their annotated locations for NP_001273639.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has an alternate in-frame exon in place of another in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini and is the same length but has an alternate internal segment compared to isoform a. Variants 3 and 13-16 all encode the same isoform (b).
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS68826.1
      UniProtKB/TrEMBL
      A8K9T3
      Related
      ENSP00000426150.1, ENST00000513317.5
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    3. NM_001286711.2 → NP_001273640.1  long-chain-fatty-acid--CoA ligase 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS68825.1
      UniProtKB/TrEMBL
      B4E0R0, E7EPM6, E7EQJ5
      Related
      ENSP00000426244.1, ENST00000507295.5
      Conserved Domains (2) summary
      PLN02736
      Location:86 → 662
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:116 → 659
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    4. NM_001381877.1 → NP_001368806.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 2, and 7-12, encodes isoform a.
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS3839.1
      UniProtKB/Swiss-Prot
      B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
      UniProtKB/TrEMBL
      A8K9T3
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    5. NM_001381878.1 → NP_001368807.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 2, 6, and 8-12, encodes isoform a.
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS3839.1
      UniProtKB/Swiss-Prot
      B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
      UniProtKB/TrEMBL
      A8K9T3
      Related
      ENSP00000516354.1, ENST00000706369.1
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    6. NM_001381879.1 → NP_001368808.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 1, 2, 6, 7, and 9-12, encodes isoform a.
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS3839.1
      UniProtKB/Swiss-Prot
      B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
      UniProtKB/TrEMBL
      A8K9T3
      Related
      ENSP00000516352.1, ENST00000706367.1
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    7. NM_001381880.1 → NP_001368809.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 1, 2, 6-8, and 10-12, encodes isoform a.
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS3839.1
      UniProtKB/Swiss-Prot
      B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
      UniProtKB/TrEMBL
      A8K9T3
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    8. NM_001381881.1 → NP_001368810.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 1, 2, 6-9, 11, and 12, encodes isoform a.
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS3839.1
      UniProtKB/Swiss-Prot
      B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
      UniProtKB/TrEMBL
      A8K9T3
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    9. NM_001381882.1 → NP_001368811.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 1, 2, 6-10, and 12, encodes isoform a.
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS3839.1
      UniProtKB/Swiss-Prot
      B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
      UniProtKB/TrEMBL
      A8K9T3
      Related
      ENSP00000425098.2, ENST00000503407.6
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    10. NM_001381883.1 → NP_001368812.1  long-chain-fatty-acid--CoA ligase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 1, 2, and 6-11, encodes isoform a.
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS3839.1
      UniProtKB/Swiss-Prot
      B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
      UniProtKB/TrEMBL
      A8K9T3
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    11. NM_001381884.1 → NP_001368813.1  long-chain-fatty-acid--CoA ligase 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 3 and 14-16, encodes isoform b.
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS68826.1
      UniProtKB/TrEMBL
      A8K9T3
      Related
      ENSP00000516351.1, ENST00000706366.1
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    12. NM_001381885.1 → NP_001368814.1  long-chain-fatty-acid--CoA ligase 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 3, 13, 15, and 16, encodes isoform b.
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS68826.1
      UniProtKB/TrEMBL
      A8K9T3
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    13. NM_001381886.1 → NP_001368815.1  long-chain-fatty-acid--CoA ligase 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 3, 13, 14, and 16, encodes isoform b.
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS68826.1
      UniProtKB/TrEMBL
      A8K9T3
      Related
      ENSP00000516353.1, ENST00000706368.1
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    14. NM_001381887.1 → NP_001368816.1  long-chain-fatty-acid--CoA ligase 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 3 and 13-15, encodes isoform b.
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS68826.1
      UniProtKB/TrEMBL
      A8K9T3
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    15. NM_001381888.1 → NP_001368817.1  long-chain-fatty-acid--CoA ligase 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variant 18, encodes isoform e.
      Source sequence(s)
      AC079257, AC084871
      UniProtKB/TrEMBL
      B7Z3Z9
      Conserved Domains (1) summary
      cd05927
      Location:67 → 645
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    16. NM_001381889.1 → NP_001368818.1  long-chain-fatty-acid--CoA ligase 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variant 17, encodes isoform e.
      Source sequence(s)
      AC079257, AC084871
      UniProtKB/TrEMBL
      B7Z3Z9
      Conserved Domains (1) summary
      cd05927
      Location:67 → 645
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    17. NM_001381890.1 → NP_001368819.1  long-chain-fatty-acid--CoA ligase 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871
      UniProtKB/TrEMBL
      A8K9T3
      Conserved Domains (1) summary
      cd05927
      Location:52 → 630
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    18. NM_001995.5 → NP_001986.2  long-chain-fatty-acid--CoA ligase 1 isoform a

      See identical proteins and their annotated locations for NP_001986.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 6-12 all encode the same isoform (a).
      Source sequence(s)
      AC079257, AC084871
      Consensus CDS
      CCDS3839.1
      UniProtKB/Swiss-Prot
      B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
      UniProtKB/TrEMBL
      A8K9T3
      Related
      ENSP00000281455.2, ENST00000281455.7
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    RNA

    1. NR_167698.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871

    2. NR_167702.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871

    3. NR_167703.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871
      Related
      ENST00000454703.6

    4. NR_167704.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871

    5. NR_167705.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871

    6. NR_167706.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871

    7. NR_167708.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871

    8. NR_167709.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079257, AC084871

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      184755595..184826594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007887.2 → XP_016863376.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

      UniProtKB/Swiss-Prot
      B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99
      UniProtKB/TrEMBL
      A8K9T3
      Related
      ENSP00000422607.1, ENST00000515030.5
      Conserved Domains (1) summary
      cd05927
      Location:116 → 694
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    2. XM_047449819.1 → XP_047305775.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      188099036..188170021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349256.1 → XP_054205231.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

      UniProtKB/Swiss-Prot
      B7Z452, D3DP57, P33121, P41215, Q8N8V7, Q8TA99

    2. XM_054349255.1 → XP_054205230.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001286712.1: Suppressed sequence

      Description
      NM_001286712.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33121.1 GenPept UniProtKB/Swiss-Prot:P33121

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous