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    Zfp980 zinc finger protein 980 [ Mus musculus (house mouse) ]

    Gene ID: 100041379, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp980provided by MGI
    Official Full Name
    zinc finger protein 980provided by MGI
    Primary source
    MGI:MGI:3712454
    See related
    Ensembl:ENSMUSG00000058186 AllianceGenome:MGI:3712454
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm13242
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in nucleus. Is expressed in epiblast; primitive endoderm; and trophectoderm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Zfp980 in Genome Data Viewer
    Location:
    4 E1; 4 78.23 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (145397267..145431007)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (145670697..145704437)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr4:145243801-145244102 Neighboring gene predicted gene 13249 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145254570-145254871 Neighboring gene STARR-seq mESC enhancer starr_12035 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145269028-145269328 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145271302-145271602 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145274293-145274594 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145275073-145275374 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145276526-145276827 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145276879-145277180 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145277691-145277992 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145278790-145279091 Neighboring gene STARR-positive B cell enhancer mm9_chr4:145281441-145281742 Neighboring gene high mobility group box 3 pseudogene Neighboring gene vomeronasal 2, receptor, pseudogene 15 Neighboring gene predicted gene, 26763 Neighboring gene predicted gene 13232

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. Dietrich JE, et al. EMBO Rep, 2015 Aug. PMID 26142281, Free PMC Article
    2. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106319

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC100041379

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103158.2 → NP_001096628.2  uncharacterized protein LOC100041379

      Status: VALIDATED

      Source sequence(s)
      BC096593, CD539619
      Consensus CDS
      CCDS51370.1
      UniProtKB/TrEMBL
      A2A9J5
      Related
      ENSMUSP00000101364.3, ENSMUST00000105738.9
      Conserved Domains (5) summary
      smart00349
      Location:28 → 70
      KRAB; krueppel associated box
      COG5048
      Location:96 → 510
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:28 → 67
      KRAB; KRAB box
      pfam13465
      Location:602 → 626
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      145397267..145431007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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