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    Tmem132c transmembrane protein 132C [ Mus musculus (house mouse) ]

    Gene ID: 208213, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmem132cprovided by MGI
    Official Full Name
    transmembrane protein 132Cprovided by MGI
    Primary source
    MGI:MGI:2443061
    See related
    Ensembl:ENSMUSG00000034324 AllianceGenome:MGI:2443061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3230401P16; 2810482M11Rik; 4632425D07Rik
    Summary
    Predicted to be involved in negative regulation of phosphatase activity. Predicted to be located in membrane. Is expressed in several structures, including central nervous system; jaw; sensory organ; skin; and surface ectoderm. Orthologous to human TMEM132C (transmembrane protein 132C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 9.3), subcutaneous fat pad adult (RPKM 6.5) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem132c in Genome Data Viewer
    Location:
    5 G1.2; 5 65.4 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (127318890..127642854)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (127241826..127565790)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930572K03 gene Neighboring gene RIKEN cDNA 4930548G05 gene Neighboring gene STARR-seq mESC enhancer starr_14399 Neighboring gene transmembrane protein 132C, opposite strand Neighboring gene predicted gene, 54294 Neighboring gene STARR-seq mESC enhancer starr_14401 Neighboring gene STARR-seq mESC enhancer starr_14404 Neighboring gene STARR-seq mESC enhancer starr_14405 Neighboring gene solute carrier family 15, member 4 Neighboring gene STARR-seq mESC enhancer starr_14412 Neighboring gene STARR-seq mESC enhancer starr_14414 Neighboring gene glycosyltransferase 1 domain containing 1 Neighboring gene transmembrane protein 132D Neighboring gene STARR-seq mESC enhancer starr_14415 Neighboring gene STARR-seq mESC enhancer starr_14419

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential expression of the Tmem132 family genes in the developing mouse nervous system. Wang Y, et al. Gene Expr Patterns, 2022 Sep. PMID 35690356, Free PMC Article
    2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 132C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175432.3 → NP_780641.2  transmembrane protein 132C precursor

      Status: VALIDATED

      Source sequence(s)
      AK028289, AK028541, AK157823
      Consensus CDS
      CCDS51650.1
      UniProtKB/Swiss-Prot
      Q8BS69, Q8CEF9
      UniProtKB/TrEMBL
      E9QP73
      Related
      ENSMUSP00000113090.2, ENSMUST00000119026.8
      Conserved Domains (3) summary
      pfam15705
      Location:58 → 187
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:892 → 980
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:444 → 786
      TMEM132; Transmembrane protein family 132

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      127318890..127642854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CEF9.3 GenPept UniProtKB/Swiss-Prot:Q8CEF9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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