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    NPSR1 neuropeptide S receptor 1 [ Homo sapiens (human) ]

    Gene ID: 387129, updated on 2-Nov-2024

    Summary

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    Official Symbol
    NPSR1provided by HGNC
    Official Full Name
    neuropeptide S receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:23631
    See related
    Ensembl:ENSG00000187258 MIM:608595; AllianceGenome:HGNC:23631
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPRA; NPSR; VRR1; ASRT2; PGR14; GPR154
    Summary
    This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See NPSR1 in Genome Data Viewer
    Location:
    7p14.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (34658218..34878332)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (34798021..35019005)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (34697830..34917944)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr7:33972520-33972786 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:34033417-34034047 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:34034048-34034677 Neighboring gene BMP binding endothelial regulator Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:34074011-34075210 Neighboring gene VISTA enhancer hs1336 Neighboring gene NANOG hESC enhancer GRCh37_chr7:34115590-34116091 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:34214913-34215520 Neighboring gene NANOG hESC enhancer GRCh37_chr7:34251459-34251988 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:34258701-34259255 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:34264670-34265500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25837 Neighboring gene RNA, U6 small nuclear 438, pseudogene Neighboring gene NPSR1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:34476732-34476921 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:34553347-34553924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:34592037-34592538 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:34691494-34692079 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:34694009-34695208 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:34699869-34700706 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:34701543-34702378 Neighboring gene ribosomal protein L7 pseudogene 31 Neighboring gene RNA, 7SL, cytoplasmic 132, pseudogene Neighboring gene non-SMC condensin I complex subunit D2 pseudogene 1 Neighboring gene uncharacterized LOC102724723 Neighboring gene dpy-19 like C-mannosyltransferase 1 Neighboring gene microRNA 548n

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NPSR1 gene is associated with reduced risk of rheumatoid arthritis. Robledo G, et al. J Rheumatol, 2012 Jun. PMID 22548958
    2. A functional variant in the neuropeptide S receptor 1 gene moderates the influence of urban upbringing on stress processing in the amygdala. Streit F, et al. Stress, 2014 Jul. PMID 24800784
    3. Interaction of NPSR1 genotypes and probiotics in the manifestation of atopic eczema in early childhood. P K, et al. Allergol Immunopathol (Madr), 2014 Nov-Dec. PMID 24439655
    4. Interaction of the neuropeptide S receptor gene Asn¹⁰⁷Ile variant and environment: contribution to affective and anxiety disorders, and suicidal behaviour. Laas K, et al. Int J Neuropsychopharmacol, 2014 Apr. PMID 24331455
    5. Enhanced expression of neuropeptide S (NPS) receptor in eosinophils from severe asthmatics and subjects with total IgE above 100IU/ml. Ilmarinen P, et al. Peptides, 2014 Jan. PMID 24239856

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NPSR1 promotes chronic colitis through regulating CD4[+] T cell effector function in inflammatory bowel disease.
      Title: NPSR1 promotes chronic colitis through regulating CD4(+) T cell effector function in inflammatory bowel disease.
    2. Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis.
      Title: Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis.
    3. Human-Specific Neuropeptide S Receptor Variants Regulate Fear Extinction in the Basal Amygdala of Male and Female Mice Depending on Threat Salience.
      Title: Human-Specific Neuropeptide S Receptor Variants Regulate Fear Extinction in the Basal Amygdala of Male and Female Mice Depending on Threat Salience.
    4. The promoting effects of hsa_circ_0050102 in pancreatic cancer and the molecular mechanism by targeting miR-1182/NPSR1.
      Title: The promoting effects of hsa_circ_0050102 in pancreatic cancer and the molecular mechanism by targeting miR-1182/NPSR1.
    5. Neuropeptide S receptor gene Asn107 polymorphism in obese male individuals in Pakistan.
      Title: Neuropeptide S receptor gene Asn107 polymorphism in obese male individuals in Pakistan.
    6. Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls.
      Title: Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls.
    7. Gene polymorphisms (rs324957, rs324981) in NPSR1 are associated with increased risk of primary insomnia: A cross-sectional study.
      Title: Gene polymorphisms (rs324957, rs324981) in NPSR1 are associated with increased risk of primary insomnia: A cross-sectional study.
    8. results support the genetic role of NPSR1 in the pathogenesis of anxiety and suggest that carriers of NPSR1 Ile-allele are at increased risk of anxiety in Hemodialysis patients. Neither BDNF Val66Met nor IL-6 G174C were linked to psychological symptoms.
      Title: Investigating the Contribution of NPSR1, IL-6 and BDNF Polymorphisms to Depressive and Anxiety Symptoms in Hemodialysis Patients.
    9. RORA* NPSR1 interactions appear to be involved in mechanisms specific for nocturnal asthma
      Title: Nocturnal asthma is affected by genetic interactions between RORA and NPSR1.
    10. findings of this study provide some evidence that the NPSR1 and GAD1 polymorphisms might play a role in the development of war-related PTSD and its related psychological expressions; further research is needed to elucidate the interactions of specific gene variants and environmental factors in the development of PTSD
      Title: Association of Neuropeptide S Receptor 1 and Glutamate Decarboxylase 1 Gene Polymorphisms with Posttraumatic Stress Disorder.
    Submit: New GeneRIF Correction See all GeneRIFs (84)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Asthma-related traits, susceptibility to, 2
    MedGen: C1837811 OMIM: 608584 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables vasopressin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in eating behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of defecation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of eating behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of release of sequestered calcium ion into cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in righting reflex IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    neuropeptide S receptor
    Names
    G-protein coupled receptor 154
    G-protein coupled receptor PGR14
    G-protein coupled receptor for asthma susceptibility
    vasopressin receptor-related receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012185.2 RefSeqGene

      Range
      4934..196694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300933.2 → NP_001287862.1  neuropeptide S receptor isoform B short

      See identical proteins and their annotated locations for NP_001287862.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, and uses an alternate 3-terminal exon, compared to variant 1. The encoded isoform (B short, 15947423) is shorter and has a distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AC005493, AK172847, AY310328
      Consensus CDS
      CCDS75580.1
      UniProtKB/TrEMBL
      A0A090N8G9
      Related
      ENSP00000433258.1, ENST00000531252.5
      Conserved Domains (1) summary
      pfam00001
      Location:66 → 319
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_001300934.2 → NP_001287863.1  neuropeptide S receptor isoform F

      See identical proteins and their annotated locations for NP_001287863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (F, PMID: 15947423) is shorter, compared to isoform A.
      Source sequence(s)
      AC005493, AK172847, AY310332
      Consensus CDS
      CCDS75581.1
      UniProtKB/TrEMBL
      B7ZMA2
      Related
      ENSP00000370953.1, ENST00000381542.5
      Conserved Domains (1) summary
      pfam00001
      Location:95 → 264
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. NM_001300935.2 → NP_001287864.1  neuropeptide S receptor isoform G

      See identical proteins and their annotated locations for NP_001287864.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (G) has a longer and distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AC005493, AK172847, AY310326, AY956448
      Consensus CDS
      CCDS75579.1
      UniProtKB/TrEMBL
      A0A090N8G9
      Related
      ENSP00000370950.3, ENST00000381539.3
      Conserved Domains (1) summary
      pfam00001
      Location:66 → 330
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    4. NM_207172.2 → NP_997055.1  neuropeptide S receptor isoform A

      See identical proteins and their annotated locations for NP_997055.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform A (PMID: 15947423).
      Source sequence(s)
      AC005493, AY310326
      Consensus CDS
      CCDS5444.1
      UniProtKB/Swiss-Prot
      A2RTZ4, Q2XP58, Q56H76, Q56H77, Q56H78, Q6JSL4, Q6JSL5, Q6JSL6, Q6JSL7, Q6JSL8, Q6W5P3, Q6W5P4, Q6ZMB8
      UniProtKB/TrEMBL
      A0A090N8G9, A0A090N8Z1
      Related
      ENSP00000353788.1, ENST00000360581.6
      Conserved Domains (1) summary
      pfam00001
      Location:66 → 330
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    5. NM_207173.2 → NP_997056.1  neuropeptide S receptor isoform B

      See identical proteins and their annotated locations for NP_997056.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1. The encoded isoform (B, PMID: 15947423) has a longer and distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AC005493, AY310327
      Consensus CDS
      CCDS5443.1
      UniProtKB/TrEMBL
      A0A090N8G9
      Related
      ENSP00000352839.1, ENST00000359791.5
      Conserved Domains (1) summary
      cd15197
      Location:50 → 341
      7tmA_NPSR; neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      34658218..34878332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      34798021..35019005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6W5P4.1 GenPept UniProtKB/Swiss-Prot:Q6W5P4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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