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    MIR22HG MIR22 host gene [ Homo sapiens (human) ]

    Gene ID: 84981, updated on 27-Aug-2024

    Summary

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    Official Symbol
    MIR22HGprovided by HGNC
    Official Full Name
    MIR22 host geneprovided by HGNC
    Primary source
    HGNC:HGNC:28219
    See related
    Ensembl:ENSG00000186594 AllianceGenome:HGNC:28219
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C17orf91
    Summary
    Predicted to act upstream of or within response to wounding. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal (RPKM 35.5), bone marrow (RPKM 31.9) and 24 other tissues See more
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    Genomic context

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    Location:
    17p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (1711504..1716210, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (1600429..1605139, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1614798..1619566, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1554397-1554907 Neighboring gene pre-mRNA processing factor 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1593390-1593890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1593891-1594391 Neighboring gene TLC domain containing 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1619651-1620292 Neighboring gene microRNA 22 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1627561-1628061 Neighboring gene WD repeat domain 81 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1638655-1639172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1639173-1639688 Neighboring gene Sharpr-MPRA regulatory region 4635 Neighboring gene serpin family F member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1655564-1656124

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Pan-cancer analysis of the expression pattern of long non-coding RNA MIR22HG]. Wang H, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2022 Apr 20. PMID 35527483, Free PMC Article
    2. LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway. Long H, et al. Bioengineered, 2021 Dec. PMID 34187303, Free PMC Article
    3. Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers. Zhang L, et al. J Exp Clin Cancer Res, 2020 Dec 3. PMID 33267888, Free PMC Article
    4. MIR22HG regulates miR-486/PTEN axis in bladder cancer to promote cell proliferation. Tang Q, et al. Biosci Rep, 2020 Jun 26. PMID 32500915, Free PMC Article
    5. Long noncoding RNA MIR22HG is down-regulated in prostate cancer. Shen H, et al. Math Biosci Eng, 2019 Dec 17. PMID 32233607

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA MIR22HG/microRNA-9-3p/IGF1 in nonalcoholic steatohepatitis, the ceRNA network increases fibrosis by inhibiting autophagy and promoting pyroptosis.
      Title: LncRNA MIR22HG/microRNA-9-3p/IGF1 in nonalcoholic steatohepatitis, the ceRNA network increases fibrosis by inhibiting autophagy and promoting pyroptosis.
    2. Long non-coding RNA MIR22HG suppresses the chondrogenic differentiation of human adipose-derived stem cells by interacting with CTCF to upregulate CRLF1.
      Title: Long non-coding RNA MIR22HG suppresses the chondrogenic differentiation of human adipose-derived stem cells by interacting with CTCF to upregulate CRLF1.
    3. Long non-coding RNA MIR22HG inhibits the proliferation and migration, and promotes apoptosis by targeting microRNA-9-3p/ SOCS1 axis in small cell lung cancer cells.
      Title: Long non-coding RNA MIR22HG inhibits the proliferation and migration, and promotes apoptosis by targeting microRNA-9-3p/ SOCS1 axis in small cell lung cancer cells.
    4. Long non-coding RNA MIR22HG suppresses cell proliferation and promotes apoptosis in prostate cancer cells by sponging microRNA-9-3p.
      Title: Long non-coding RNA MIR22HG suppresses cell proliferation and promotes apoptosis in prostate cancer cells by sponging microRNA-9-3p.
    5. [Pan-cancer analysis of the expression pattern of long non-coding RNA MIR22HG].
      Title: [Pan-cancer analysis of the expression pattern of long non-coding RNA MIR22HG].
    6. Identification of circulating miR-22-3p and let-7a-5p as novel diagnostic biomarkers for rheumatoid arthritis.
      Title: Identification of circulating miR-22-3p and let-7a-5p as novel diagnostic biomarkers for rheumatoid arthritis.
    7. MIR22HG inhibits breast cancer progression by stabilizing LATS2 tumor suppressor.
      Title: MIR22HG inhibits breast cancer progression by stabilizing LATS2 tumor suppressor.
    8. LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway.
      Title: LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway.
    9. Overexpression of Long Non-Coding RNA MIR22HG Represses Proliferation and Enhances Apoptosis via miR-629-5p/TET3 Axis in Osteosarcoma Cells.
      Title: Overexpression of Long Non-Coding RNA MIR22HG Represses Proliferation and Enhances Apoptosis via miR-629-5p/TET3 Axis in Osteosarcoma Cells.
    10. Long noncoding RNA MIR22HG is down-regulated in prostate cancer.
      Title: Long noncoding RNA MIR22HG is down-regulated in prostate cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.
    EBI GWAS Catalog
    Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • MIR22 host gene (non-protein coding)

    Clone Names

    • MGC14376, MGC149751, DKFZp686O06159

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of RISC complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_028502.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC130343
      Related
      ENST00000574306.2

    2. NR_028503.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC130343
      Related
      ENST00000575626.6

    3. NR_028504.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC130343
      Related
      ENST00000334146.9

    4. NR_028505.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC130343
      Related
      ENST00000690262.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      1711504..1716210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187611.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      141532..146238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      1600429..1605139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001001870.1: Suppressed sequence

      Description
      NM_001001870.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.

    2. NM_032895.2: Suppressed sequence

      Description
      NM_032895.2: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VDD5.1 GenPept UniProtKB/Swiss-Prot:Q0VDD5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials