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    ZNF207 zinc finger protein 207 [ Homo sapiens (human) ]

    Gene ID: 7756, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ZNF207provided by HGNC
    Official Full Name
    zinc finger protein 207provided by HGNC
    Primary source
    HGNC:HGNC:12998
    See related
    Ensembl:ENSG00000010244 MIM:603428; AllianceGenome:HGNC:12998
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BuGZ; hBuGZ
    Summary
    Enables microtubule binding activity. Involved in mitotic spindle assembly checkpoint signaling; nuclear chromosome segregation; and protein stabilization. Located in kinetochore; nuclear lumen; and spindle matrix. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 30.2), lymph node (RPKM 22.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF207 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (32350157..32381885)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (33295928..33327660)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (30677176..30708904)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene rhomboid like 3 Neighboring gene uncharacterized LOC124903980 Neighboring gene chromosome 17 open reading frame 75 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:30668222-30668404 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:30668873-30669759 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:30673436-30673617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:30679433-30679942 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:30681259-30681760 Neighboring gene MPRA-validated peak2801 silencer Neighboring gene oocyte secreted protein 1 pseudogene 2 Neighboring gene microRNA 632 Neighboring gene nudix hydrolase 15 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:30771309-30771924 Neighboring gene proteasome 26S subunit, non-ATPase 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF207, a ubiquitously expressed zinc finger gene on chromosome 6p21.3. Pahl PM, et al. Genomics, 1998 Nov 1. PMID 9799612
    2. [Expression of ZNF207 in hepatocellular carcinoma and its significance]. Zhou C, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2019 Apr 28. PMID 31113916
    3. BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis. Shirnekhi HK, et al. J Biol Chem, 2020 Oct 23. PMID 32820050, Free PMC Article
    4. A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells. Fang F, et al. Nat Commun, 2018 Oct 22. PMID 30349051, Free PMC Article
    5. System analysis based on the cancer-immunity cycle identifies ZNF207 as a novel immunotherapy target for hepatocellular carcinoma. Wang X, et al. J Immunother Cancer, 2022 Mar. PMID 35246476, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3.
      Title: SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3.
    2. System analysis based on the cancer-immunity cycle identifies ZNF207 as a novel immunotherapy target for hepatocellular carcinoma.
      Title: System analysis based on the cancer-immunity cycle identifies ZNF207 as a novel immunotherapy target for hepatocellular carcinoma.
    3. BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis.
      Title: BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis.
    4. ZNF207 expression is elevated in hepatocellular carcinoma
      Title: [Expression of ZNF207 in hepatocellular carcinoma and its significance].
    5. a distinct isoform of ZNF207 functions in hESCs at the nexus that balances pluripotency and differentiation to ectoderm.
      Title: A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells.
    6. the two zinc fingers of BuGZ directly bind to AurA and BuGZ coacervation appears to promote AurA activation during spindle assembly.
      Title: Aurora A activation in mitosis promoted by BuGZ.
    7. BuGZ forms temperature-dependent liquid droplets alone or on microtubules in physiological buffers. Coacervation in vitro or in spindle and spindle matrix depends on hydrophobic residues in BuGZ. BuGZ coacervation and its binding to microtubules and tubulin are required to promote assembly of spindle and spindle matrix in Xenopus egg extract and in mammalian cells.
      Title: Phase transition of spindle-associated protein regulate spindle apparatus assembly.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp761N202

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule bundle formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BUB3-interacting and GLEBS motif-containing protein ZNF207

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032293.3 → NP_001027464.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform b

      See identical proteins and their annotated locations for NP_001027464.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 3. It encodes isoform b, which is shorter than isoform c.
      Source sequence(s)
      AC005899, AI308956, BC002372
      Consensus CDS
      CCDS32614.1
      UniProtKB/TrEMBL
      Q59G94
      Related
      ENSP00000378168.2, ENST00000394673.6
      Conserved Domains (3) summary
      sd00020
      Location:13 → 34
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam06003
      Location:405 → 440
      SMN; Survival motor neuron protein (SMN)
      cd20908
      Location:10 → 90
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    2. NM_001098507.2 → NP_001091977.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform c

      See identical proteins and their annotated locations for NP_001091977.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AC005899, AI308956, AK226172, BC002372
      Consensus CDS
      CCDS42294.1
      UniProtKB/TrEMBL
      Q59G94
      Related
      ENSP00000378165.4, ENST00000394670.9
      Conserved Domains (3) summary
      sd00017
      Location:13 → 32
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam06003
      Location:436 → 471
      SMN; Survival motor neuron protein (SMN)
      cd20908
      Location:10 → 90
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    3. NM_003457.4 → NP_003448.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform a

      See identical proteins and their annotated locations for NP_003448.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an in-frame exon in the coding region, compared to variant 3. It encodes isoform a, which is shorter than isoform c.
      Source sequence(s)
      AC005899, AF046001, AI308956, BC002372
      Consensus CDS
      CCDS11271.1
      UniProtKB/Swiss-Prot
      A8K6Y6, E1P660, E1P661, E1P662, O43670, Q53XS9, Q96HW5, Q9BUQ7
      UniProtKB/TrEMBL
      Q59G94
      Related
      ENSP00000322777.6, ENST00000321233.10
      Conserved Domains (3) summary
      PHA03247
      Location:224 → 436
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:13 → 32
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:10 → 90
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      32350157..32381885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      33295928..33327660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43670.1 GenPept UniProtKB/Swiss-Prot:O43670

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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