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    SAMD10 sterile alpha motif domain containing 10 [ Homo sapiens (human) ]

    Gene ID: 140700, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SAMD10provided by HGNC
    Official Full Name
    sterile alpha motif domain containing 10provided by HGNC
    Primary source
    HGNC:HGNC:16129
    See related
    Ensembl:ENSG00000130590 AllianceGenome:HGNC:16129
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    dJ591C20; C20orf136; dJ591C20.7
    Summary
    Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasmic side of plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 2.3), stomach (RPKM 1.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SAMD10 in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (63974116..63980144, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65793877..65799906, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62605469..62610995, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62573671-62574384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62574385-62575096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62580108-62580646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62580647-62581185 Neighboring gene uridine-cytidine kinase 1 like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62581186-62581724 Neighboring gene microRNA 647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62587955-62588842 Neighboring gene UCKL1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62588843-62589728 Neighboring gene zinc finger protein 512B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62599635-62600172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62600173-62600708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13196 Neighboring gene Sharpr-MPRA regulatory region 2003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62610429-62610944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13198 Neighboring gene pre-mRNA processing factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62631004-62631506 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62636447-62636619 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:62642795-62643994 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:62648052-62649251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62667815-62668408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62668409-62669002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13201 Neighboring gene chromosome 20 open reading frame 204

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Eeles RA, et al. Nat Genet, 2013 Apr. PMID 23535732, Free PMC Article
    2. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
    3. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
    4. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sterile alpha motif domain-containing protein 10
    Names
    D930033N23Rik
    SAM domain-containing protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080621.5 → NP_542188.1  sterile alpha motif domain-containing protein 10

      See identical proteins and their annotated locations for NP_542188.1

      Status: VALIDATED

      Source sequence(s)
      BC067362, BM839907
      Consensus CDS
      CCDS13549.1
      UniProtKB/Swiss-Prot
      Q9BYL1
      Related
      ENSP00000358902.3, ENST00000369886.8
      Conserved Domains (1) summary
      cd09510
      Location:113 → 187
      SAM_aveugle-like; SAM domain of aveugle-like subfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      63974116..63980144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528565.3 → XP_011526867.2  sterile alpha motif domain-containing protein 10 isoform X1

    2. XM_006723705.4 → XP_006723768.1  sterile alpha motif domain-containing protein 10 isoform X3

      Conserved Domains (2) summary
      cd09510
      Location:119 → 193
      SAM_aveugle-like; SAM domain of aveugle-like subfamily
      smart00454
      Location:121 → 188
      SAM; Sterile alpha motif

    3. XM_005260199.5 → XP_005260256.1  sterile alpha motif domain-containing protein 10 isoform X2

      Conserved Domains (2) summary
      cd09510
      Location:152 → 226
      SAM_aveugle-like; SAM domain of aveugle-like subfamily
      smart00454
      Location:154 → 221
      SAM; Sterile alpha motif

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      65793877..65799906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323004.1 → XP_054178979.1  sterile alpha motif domain-containing protein 10 isoform X1

    2. XM_054323005.1 → XP_054178980.1  sterile alpha motif domain-containing protein 10 isoform X2

    3. XM_054323007.1 → XP_054178982.1  sterile alpha motif domain-containing protein 10 isoform X4

      UniProtKB/Swiss-Prot
      Q9BYL1

    4. XM_054323006.1 → XP_054178981.1  sterile alpha motif domain-containing protein 10 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BYL1.1 GenPept UniProtKB/Swiss-Prot:Q9BYL1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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