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    SVIL-AS1 SVIL antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 102724316, updated on 22-Oct-2024

    Summary

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    Official Symbol
    SVIL-AS1provided by HGNC
    Official Full Name
    SVIL antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:51219
    See related
    Ensembl:ENSG00000291093 AllianceGenome:HGNC:51219
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in heart (RPKM 7.5), esophagus (RPKM 7.4) and 25 other tissues See more
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    Genomic context

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    See SVIL-AS1 in Genome Data Viewer
    Location:
    10p11.23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (29409534..29487856)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (29441210..29518924)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (29698463..29776785)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984217 Neighboring gene uncharacterized LOC105376473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:29683525-29684039 Neighboring gene uncharacterized LOC105376474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3195 Neighboring gene patched domain containing 3 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:29761791-29762353 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:29762354-29762917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:29766445-29766944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:29767812-29768343 Neighboring gene NANOG hESC enhancer GRCh37_chr10:29785287-29785788 Neighboring gene supervillin Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:29790285-29791484 Neighboring gene uncharacterized LOC124902401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:29805146-29805646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:29827039-29827540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:29827541-29828040 Neighboring gene microRNA 604

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. N6-methyladenosine-induced SVIL antisense RNA 1 restrains lung adenocarcinoma cell proliferation by destabilizing E2F1. Hu Z, et al. Bioengineered, 2022 Feb. PMID 35068325, Free PMC Article
    2. Long noncoding RNA expression profile in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Zhang Y, et al. Arthritis Res Ther, 2016 Oct 6. PMID 27716329, Free PMC Article
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N6-methyladenosine-induced SVIL antisense RNA 1 restrains lung adenocarcinoma cell proliferation by destabilizing E2F1.
      Title: N6-methyladenosine-induced SVIL antisense RNA 1 restrains lung adenocarcinoma cell proliferation by destabilizing E2F1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Other Names

    • RP11-534G20.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003930.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site in the 5' terminal exon, lacks an internal exon and contains an alternate 3' terminal exon, compared to variant 1.
      Source sequence(s)
      AA564262, BC031656, DA024320
      Related
      ENST00000427063.9

    2. NR_110920.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AL158167, BC063483, BM925434, DA024320

    3. NR_110921.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1.
      Source sequence(s)
      AL158167, BC063483, DA024320, DA952579
      Related
      ENST00000414457.7

    4. NR_110922.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' terminal exon and lacks an alternate internal exon, compared to variant 1.
      Source sequence(s)
      AL158167, BC063483, DA024320
      Related
      ENST00000423223.7

    5. NR_110923.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' terminal exon, lacks an internal exon and contains an alternate 3' terminal exon, compared to variant 1.
      Source sequence(s)
      AA564262, BC107795, DA024320, DA745252

    6. NR_110924.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an internal exon and contains an alternate 3' terminal exon, compared to variant 1.
      Source sequence(s)
      AA564262, BC107795, DA024320
      Related
      ENST00000623175.5

    7. NR_110925.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an internal exon and contains an alternate 3' terminal exon, compared to variant 1.
      Source sequence(s)
      AL158167, BF739922, DA024320, DA715011
      Related
      ENST00000445521.7

    8. NR_110926.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate splice site in the 5' terminal exon, lacks an internal exon and contains an alternate 3' terminal exon, compared to variant 1.
      Source sequence(s)
      AL158167, BF739922, BX461223, DA024320
      Related
      ENST00000686207.2

    9. NR_110927.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) uses an alternate splice site in the 5' terminal exon, lacks an internal exon and contains an alternate 3' terminal exon, compared to variant 1.
      Source sequence(s)
      AL158167, BC066966, DA024320
      Related
      ENST00000700912.2

    10. NR_110928.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) contains alternate 5' and 3' terminal exons, and lacks an internal exon, compared to variant 1.
      Source sequence(s)
      BF511092, BF739922
      Related
      ENST00000455774.1

    11. NR_110929.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) uses an alternate splice site in the 5' terminal exon, lacks an internal exon and contains an alternate 3' terminal exon, compared to variant 1.
      Source sequence(s)
      BF739922, DA024320
      Related
      ENST00000701307.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      29409534..29487856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      29441210..29518924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials