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    FBXO16 F-box protein 16 [ Homo sapiens (human) ]

    Gene ID: 157574, updated on 15-Oct-2024

    Summary

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    Official Symbol
    FBXO16provided by HGNC
    Official Full Name
    F-box protein 16provided by HGNC
    Primary source
    HGNC:HGNC:13618
    See related
    Ensembl:ENSG00000214050 MIM:608519; AllianceGenome:HGNC:13618
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBX16
    Summary
    This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
    Expression
    Broad expression in thyroid (RPKM 3.3), brain (RPKM 2.1) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FBXO16 in Genome Data Viewer
    Location:
    8p21.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (28428412..28490229, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (28706607..28768389, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (28285929..28347746, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28203430-28203930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:28205819-28206378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:28206379-28206938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28216758-28217258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28217259-28217759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27167 Neighboring gene zinc finger protein 395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28222946-28223446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27168 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:28241577-28241751 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27170 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27171 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:28268555-28269173 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:28269174-28269793 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:28277089-28277305 Neighboring gene RNA, U6 small nuclear 178, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19060 Neighboring gene VISTA enhancer hs1329 Neighboring gene frizzled class receptor 3 Neighboring gene microRNA 4288 Neighboring gene RNA, 5S ribosomal pseudogene 259

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and expression analysis of a novel human F-box only protein. Cheng H, et al. Mol Cells, 2002 Aug 31. PMID 12243353
    2. Attenuation of Tumor Suppressive Function of FBXO16 Ubiquitin Ligase Activates Wnt Signaling In Glioblastoma. Khan M, et al. Neoplasia, 2019 Jan. PMID 30530053, Free PMC Article
    3. MIR937 amplification potentiates ovarian cancer progression by attenuating FBXO16 inhibition on ULK1-mediated autophagy. Zhang Z, et al. Cell Death Dis, 2024 Oct 9. PMID 39384743, Free PMC Article
    4. FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer. Ji M, et al. Cell Death Dis, 2021 Jul 31. PMID 34333526, Free PMC Article
    5. F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear β-catenin function. Paul D, et al. J Pathol, 2019 Jul. PMID 30714168, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MIR937 amplification potentiates ovarian cancer progression by attenuating FBXO16 inhibition on ULK1-mediated autophagy.
      Title: MIR937 amplification potentiates ovarian cancer progression by attenuating FBXO16 inhibition on ULK1-mediated autophagy.
    2. FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer.
      Title: FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer.
    3. that FBXO16 functions as a putative tumor suppressor by forming an SCF(FBXO16) complex that targets nuclear beta-catenin in a unique manner for ubiquitination and subsequent proteasomal degradation to prevent malignancy
      Title: F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear β-catenin function.
    4. we show that due to low expression of FBXO16, the beta-catenin is not targeted in glioma cells leading to its nuclear accumulation resulting in active Wnt signaling. Activated Wnt signaling potentiates the glioma cells toward a highly proliferative and malignant state.
      Title: Attenuation of Tumor Suppressive Function of FBXO16 Ubiquitin Ligase Activates Wnt Signaling In Glioblastoma.
    5. FBXO16 was localized to the human chromosome 8p12. The FBXO16 gene consisted of 9 exons that spanned 67,816 bp of human genomic DNA
      Title: cDNA cloning and expression analysis of a novel human F-box only protein.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: ZNF395

    Homology

    Clone Names

    • MGC125923, MGC125924, MGC125925

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box only protein 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258211.2 → NP_001245140.1  F-box only protein 16 isoform 2

      See identical proteins and their annotated locations for NP_001245140.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
      Source sequence(s)
      AA765256, AC025871, BC102028
      Consensus CDS
      CCDS59099.1
      UniProtKB/TrEMBL
      J3KNU2
      Related
      ENSP00000429687.1, ENST00000518734.5
      Conserved Domains (1) summary
      pfam12937
      Location:80 → 123
      F-box-like; F-box-like

    2. NM_172366.4 → NP_758954.1  F-box only protein 16 isoform 1

      See identical proteins and their annotated locations for NP_758954.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AC025871, AF453435, CB134505
      Consensus CDS
      CCDS6068.1
      UniProtKB/Swiss-Prot
      Q3T1B2, Q3T1B3, Q3T1B4, Q8IX29
      UniProtKB/TrEMBL
      J3KNU2
      Related
      ENSP00000369604.2, ENST00000380254.7
      Conserved Domains (1) summary
      pfam12937
      Location:92 → 129
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      28428412..28490229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      28706607..28768389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IX29.1 GenPept UniProtKB/Swiss-Prot:Q8IX29

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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