Lpcat3 lysophosphatidylcholine acyltransferase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lpcat3provided by MGI
Official Full Name: lysophosphatidylcholine acyltransferase 3provided by MGI
Primary source: MGI:MGI:1315211
See related: Ensembl:ENSMUSG00000004270 AllianceGenome:MGI:1315211
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C3f; PTG; Lpcat; Lpeat; Lpsat; Oact5; Grcc3f; Lplat5; Mboat5; Moact5
Summary: Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in several processes, including glycerophospholipid metabolic process; intestinal stem cell homeostasis; and plasma lipoprotein particle assembly. Acts upstream of or within regulation of plasma lipoprotein particle levels. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; hemolymphoid system; and liver. Orthologous to human LPCAT3 (lysophosphatidylcholine acyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 97.2), testis adult (RPKM 92.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F2; 6 59.17 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (124639887..124681142)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (124663094..124704716)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis.
Title: Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis.
Methylation Regulation of LPCAT3 Improves Osteoarthritis by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis.
Title: Methylation Regulation of LPCAT3 Improves Osteoarthritis by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis.
Hyperuricemia induces lipid disturbances mediated by LPCAT3 upregulation in the liver.
Title: Hyperuricemia induces lipid disturbances mediated by LPCAT3 upregulation in the liver.
ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease.
Title: ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease.
The role of the small intestine in modulating metabolism and inflammation in atherosclerosis and cancer.
Title: The role of the small intestine in modulating metabolism and inflammation in atherosclerosis and cancer.
LPCAT3 is depleted in non-alcoholic steatohepatitis and leads to caspase-dependent/caspase-independent cell death.
Title: Caspase-independent hepatocyte death: A result of the decrease of lysophosphatidylcholine acyltransferase 3 in non-alcoholic steatohepatitis.
LPCAT3 as a key factor in the control of phospholipid homeostasis and arachidonate availability in myeloid cells and its deficiency in hematopoietic cells alters cholesterol and phospholipid homeostasis and promotes atherosclerosis.
Title: LPCAT3 deficiency in hematopoietic cells alters cholesterol and phospholipid homeostasis and promotes atherosclerosis.
Study show for the first time that LPCAT3 is the major isoform of LPCAT in 3T3L1 pre-adipocytes, and mature adipocytes, as well as mouse adipose tissue, and that LPCAT3 activity-mediated phosphatidylcholine (PC) remodeling affects adipocyte polyunsaturated PC composition, most likely on the cell membrane, thus influencing Wnt/beta-catenin signaling pathway and inhibiting pre-adipocyte differentiation and lipogenesis.
Title: Lysophosphatidylcholine acyltransferase 3 deficiency impairs 3T3L1 cell adipogenesis through activating Wnt/β-catenin pathway.
Regulation of LPCAT3 expression might be associated with atherosclerotic progression in humans.
Title: Lysophosphatidylcholine Acyltransferase-3 Expression Is Associated with Atherosclerosis Progression.
findings identify LPCAT3 as a direct PPARdelta target gene and suggest a novel function of PPARdelta in regulation of phospholipid metabolism through LPCAT3.
Title: Identification of Hepatic Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated by Peroxisome Proliferator-activated Receptor δ.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-acylglycerophosphocholine O-acyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 1-acylglycerophosphocholine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerophosphoserine O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-acylglycerophosphoserine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables lysophospholipid acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chylomicron assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine acyl-chain remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylcholine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine acyl-chain remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine acyl-chain remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylethanolamine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylserine acyl-chain remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylserine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intestinal cholesterol absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of triglyceride transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cholesterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of plasma lipoprotein particle levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in very-low-density lipoprotein particle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: lysophospholipid acyltransferase 5

Names: 1-acylglycerophosphoserine O-acyltransferase; LPC acyltransferase 3; O-acyltransferase domain-containing protein 5; lyso-PC acyltransferase 3; lyso-PE acyltransferase; lyso-PS acyltransferase; lysophosphatidylethanolamine acyltransferase; lysophosphatidylserine acyltransferase

NP_660112.1

EC 2.3.1.23

EC 2.3.1.n6

EC 2.3.1.n7

XP_036021745.1

EC 2.3.1.23

EC 2.3.1.n6

EC 2.3.1.n7

XP_036021746.1

EC 2.3.1.23

EC 2.3.1.n6

EC 2.3.1.n7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145130.3 → NP_660112.1 lysophospholipid acyltransferase 5

See identical proteins and their annotated locations for NP_660112.1

Status: VALIDATED

Source sequence(s)

AC164157

Consensus CDS

CCDS20523.1

UniProtKB/Swiss-Prot

B1B362, O35131, Q8BNH6, Q91V01

Related

ENSMUSP00000004381.8, ENSMUST00000004381.14

Conserved Domains (1) summary

pfam03062
Location:126 → 437

MBOAT; MBOAT, membrane-bound O-acyltransferase family

RNA

NR_149320.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC164157
NR_176913.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC164157
NR_176914.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC164157

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

124639887..124681142

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165853.1 → XP_036021746.1 lysophospholipid acyltransferase 5 isoform X1

Conserved Domains (1) summary

cl00738
Location:2 → 217

MBOAT; membrane-bound O-acyltransferase family
XM_036165852.1 → XP_036021745.1 lysophospholipid acyltransferase 5 isoform X1

Conserved Domains (1) summary

cl00738
Location:2 → 217

MBOAT; membrane-bound O-acyltransferase family