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    ADNP2 ADNP homeobox 2 [ Homo sapiens (human) ]

    Gene ID: 22850, updated on 27-Nov-2024

    Summary

    Official Symbol
    ADNP2provided by HGNC
    Official Full Name
    ADNP homeobox 2provided by HGNC
    Primary source
    HGNC:HGNC:23803
    See related
    Ensembl:ENSG00000101544 MIM:617422; AllianceGenome:HGNC:23803
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF508
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in nervous system development and regulation of gene expression. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bone marrow (RPKM 13.5), testis (RPKM 13.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADNP2 in Genome Data Viewer
    Location:
    18q23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (80109262..80140346)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (80385719..80416803)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (77867146..77898229)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9590 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:77808538-77809737 Neighboring gene ribosome binding factor A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:77825575-77826076 Neighboring gene RBFA downstream neighbor Neighboring gene solute carrier family 25 member 6 pseudogene 4 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:77861530-77862273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:77865569-77866070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:77866897-77867398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9592 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr18:77876558-77877483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13550 Neighboring gene PARD6G antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9594 Neighboring gene par-6 family cell polarity regulator gamma Neighboring gene uncharacterized LOC124904337

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0863

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    activity-dependent neuroprotector homeobox protein 2
    Names
    ADNP homeobox protein 2
    zinc finger protein 508

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014913.4NP_055728.1  activity-dependent neuroprotector homeobox protein 2

      See identical proteins and their annotated locations for NP_055728.1

      Status: VALIDATED

      Source sequence(s)
      AC139100, KC877689
      Consensus CDS
      CCDS32853.1
      UniProtKB/Swiss-Prot
      A8K951, O94943, Q6IQ32, Q9H9P3
      Related
      ENSP00000262198.3, ENST00000262198.9
      Conserved Domains (3) summary
      smart00389
      Location:10431096
      HOX; Homeodomain
      TIGR03437
      Location:465667
      Soli_cterm; Solibacter uncharacterized C-terminal domain
      pfam07793
      Location:238341
      DUF1631; Protein of unknown function (DUF1631)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      80109262..80140346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525883.3XP_011524185.1  activity-dependent neuroprotector homeobox protein 2 isoform X1

      Conserved Domains (3) summary
      smart00389
      Location:10211074
      HOX; Homeodomain
      TIGR03437
      Location:443645
      Soli_cterm; Solibacter uncharacterized C-terminal domain
      pfam07793
      Location:216319
      DUF1631; Protein of unknown function (DUF1631)
    2. XM_047437350.1XP_047293306.1  activity-dependent neuroprotector homeobox protein 2 isoform X1

    3. XM_047437351.1XP_047293307.1  activity-dependent neuroprotector homeobox protein 2 isoform X2

    4. XM_047437352.1XP_047293308.1  activity-dependent neuroprotector homeobox protein 2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      80385719..80416803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318291.1XP_054174266.1  activity-dependent neuroprotector homeobox protein 2 isoform X1

    2. XM_054318290.1XP_054174265.1  activity-dependent neuroprotector homeobox protein 2 isoform X1

    3. XM_054318292.1XP_054174267.1  activity-dependent neuroprotector homeobox protein 2 isoform X2

    4. XM_054318293.1XP_054174268.1  activity-dependent neuroprotector homeobox protein 2 isoform X2