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    HOXA10 homeobox A10 [ Homo sapiens (human) ]

    Gene ID: 3206, updated on 9-Dec-2024

    Summary

    Official Symbol
    HOXA10provided by HGNC
    Official Full Name
    homeobox A10provided by HGNC
    Primary source
    HGNC:HGNC:5100
    See related
    Ensembl:ENSG00000253293 MIM:142957; AllianceGenome:HGNC:5100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PL; HOX1; HOX1H; HOX1.8
    Summary
    In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011]
    Expression
    Biased expression in endometrium (RPKM 36.7), prostate (RPKM 13.4) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HOXA10 in Genome Data Viewer
    Location:
    7p15.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (27170605..27179861, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (27306614..27315870, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27210224..27219480, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27201681-27202180 Neighboring gene HOXA10-HOXA9 readthrough Neighboring gene NUP98-HOXA9 recombination region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27203692-27204569 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27204570-27205446 Neighboring gene homeobox A9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27206295-27207013 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27208203-27208793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27208794-27209384 Neighboring gene HOXA10 antisense RNA Neighboring gene microRNA 196b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27211139-27211638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27213347-27213993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27213994-27214639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27218758-27219360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27219361-27219962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27222450-27223332 Neighboring gene NUP98-HOXA11 recombination region Neighboring gene homeobox A11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27223333-27224214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27225097-27225978 Neighboring gene HOXA11 antisense RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough HOXA10-HOXA9

    Readthrough gene: HOXA10-HOXA9, Included gene: HOXA9

    Clone Names

    • MGC12859

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic limb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in prostate gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proximal/distal pattern formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in uterus development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    homeobox protein Hox-A10
    Names
    homeo box A10
    homeobox protein 1H
    homeobox protein HOXA10
    homeobox protein Hox-1.8
    homeobox protein Hox-1H

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018951.4NP_061824.3  homeobox protein Hox-A10

      See identical proteins and their annotated locations for NP_061824.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      BC013971, BF196481, BX439708
      Consensus CDS
      CCDS5410.2
      UniProtKB/Swiss-Prot
      O43370, O43605, P31260, Q15949, Q504T1
      Related
      ENSP00000283921.4, ENST00000283921.5
      Conserved Domains (1) summary
      pfam00046
      Location:339392
      Homeobox; Homeobox domain

    RNA

    1. NR_037939.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      BC013971, BC071843, BF196481, DB267919

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      27170605..27179861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      27306614..27315870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153715.3: Suppressed sequence

      Description
      NM_153715.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.