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    MAGEA6 MAGE family member A6 [ Homo sapiens (human) ]

    Gene ID: 4105, updated on 27-Nov-2024

    Summary

    Official Symbol
    MAGEA6provided by HGNC
    Official Full Name
    MAGE family member A6provided by HGNC
    Primary source
    HGNC:HGNC:6804
    See related
    Ensembl:ENSG00000197172 MIM:300176; AllianceGenome:HGNC:6804
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT1.6; MAGE6; MAGE3B; MAGE-3b
    Summary
    This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
    Expression
    Restricted expression toward testis (RPKM 6.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MAGEA6 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (152766136..152769689, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (151032689..151036258, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151934652..151938198, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAGE family member A2 Neighboring gene CSAG family member 3 Neighboring gene MAGEA6 divergent transcript Neighboring gene MAGE family member A4 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:151987738-151988937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21058 Neighboring gene centrin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of melanoma antigen family A, 6 (MAGEA6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC52297

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    melanoma-associated antigen 6
    Names
    MAGE-6 antigen
    MAGE3B antigen
    cancer/testis antigen 1.6
    cancer/testis antigen family 1, member 6
    melanoma antigen family A, 6
    melanoma antigen family A6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005363.5NP_005354.1  melanoma-associated antigen 6

      See identical proteins and their annotated locations for NP_005354.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC244102
      Consensus CDS
      CCDS76050.1
      UniProtKB/Swiss-Prot
      A8IF93, P43360, Q6NW44
      UniProtKB/TrEMBL
      Q6FGT7, Q6FHI5
      Related
      ENSP00000329199.5, ENST00000329342.10
      Conserved Domains (2) summary
      pfam01454
      Location:116280
      MAGE; MAGE family
      pfam12440
      Location:594
      MAGE_N; Melanoma associated antigen family N terminal
    2. NM_175868.4NP_787064.1  melanoma-associated antigen 6

      See identical proteins and their annotated locations for NP_787064.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC244102
      Consensus CDS
      CCDS76050.1
      UniProtKB/Swiss-Prot
      A8IF93, P43360, Q6NW44
      UniProtKB/TrEMBL
      Q6FGT7, Q6FHI5
      Related
      ENSP00000480637.1, ENST00000616035.4
      Conserved Domains (2) summary
      pfam01454
      Location:116280
      MAGE; MAGE family
      pfam12440
      Location:594
      MAGE_N; Melanoma associated antigen family N terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      152766136..152769689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791818.1 Reference GRCh38.p14 PATCHES

      Range
      313913..317471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333342.1XP_054189317.1  melanoma-associated antigen 6 isoform X1

      UniProtKB/Swiss-Prot
      A8IF93, P43360, Q6NW44
    2. XM_054333341.1XP_054189316.1  melanoma-associated antigen 6 isoform X1

      UniProtKB/Swiss-Prot
      A8IF93, P43360, Q6NW44
    3. XM_054333343.1XP_054189318.1  melanoma-associated antigen 6 isoform X1

      UniProtKB/Swiss-Prot
      A8IF93, P43360, Q6NW44

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      151032689..151036258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327060.1XP_054183035.1  melanoma-associated antigen 6 isoform X1

      UniProtKB/Swiss-Prot
      P43357, Q6FHI6
    2. XM_054327059.1XP_054183034.1  melanoma-associated antigen 6 isoform X1

      UniProtKB/Swiss-Prot
      P43357, Q6FHI6
    3. XM_054327061.1XP_054183036.1  melanoma-associated antigen 6 isoform X1

      UniProtKB/Swiss-Prot
      P43357, Q6FHI6