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    Csnk1g3 casein kinase 1, gamma 3 [ Mus musculus (house mouse) ]

    Gene ID: 70425, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Csnk1g3provided by MGI
    Official Full Name
    casein kinase 1, gamma 3provided by MGI
    Primary source
    MGI:MGI:1917675
    See related
    Ensembl:ENSMUSG00000073563 AllianceGenome:MGI:1917675
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3300002K07Rik; C330049O21Rik
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in endocytosis; positive regulation of canonical Wnt signaling pathway; and signal transduction. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in central nervous system; heart; jaw bone; and retina. Orthologous to human CSNK1G3 (casein kinase 1 gamma 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 12.9), CNS E14 (RPKM 11.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Csnk1g3 in Genome Data Viewer
    Location:
    18 D1- D2; 18 29.1 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (53995154..54088756)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (53862082..53955684)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19466 Neighboring gene STARR-seq mESC enhancer starr_44626 Neighboring gene centrosomal protein 120 Neighboring gene STARR-positive B cell enhancer ABC_E966 Neighboring gene STARR-positive B cell enhancer ABC_E8978 Neighboring gene STARR-seq mESC enhancer starr_44627 Neighboring gene STARR-positive B cell enhancer ABC_E9449 Neighboring gene STARR-positive B cell enhancer mm9_chr18:54037188-54037489 Neighboring gene predicted gene, 41728 Neighboring gene STARR-positive B cell enhancer ABC_E5659 Neighboring gene STARR-positive B cell enhancer ABC_E1516 Neighboring gene STARR-seq mESC enhancer starr_44629 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene high mobility group box 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3. Lee SY, et al. Cell Death Dis, 2019 Dec 4. PMID 31801942, Free PMC Article
    2. Genetic imbalances in preleukemic thymuses. Verlaet M, et al. Biochem Biophys Res Commun, 2001 Apr 27. PMID 11322760
    3. Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Trivedi CM, et al. Dev Cell, 2010 Sep 14. PMID 20833366, Free PMC Article
    4. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article
    5. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Casein kinase-1gamma1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3.
      Title: Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase I isoform gamma-3; casein kinase I
    Names
    CKI-gamma 3
    NP_690022.2
    XP_006526293.1
    XP_006526294.1
    XP_006526295.1
    XP_006526296.1
    XP_006526297.1
    XP_006526298.1
    XP_006526299.1
    XP_006526300.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152809.2 → NP_690022.2  casein kinase I isoform gamma-3

      See identical proteins and their annotated locations for NP_690022.2

      Status: VALIDATED

      Source sequence(s)
      AK032675, AK034842, AK049379, AK163441, BQ443928, BY729947, CN454971
      Consensus CDS
      CCDS37823.1
      UniProtKB/Swiss-Prot
      Q8BM57, Q8C001, Q8C4X2, Q8K079
      Related
      ENSMUSP00000070259.7, ENSMUST00000069597.8
      Conserved Domains (2) summary
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:329 → 386
      CK1gamma_C; Casein kinase 1 gamma C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      53995154..54088756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526230.2 → XP_006526293.1  casein kinase I isoform X1

      See identical proteins and their annotated locations for XP_006526293.1

      Conserved Domains (2) summary
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:329 → 418
      CK1gamma_C; Casein kinase 1 gamma C terminal

    2. XM_006526233.2 → XP_006526296.1  casein kinase I isoform X4

      See identical proteins and their annotated locations for XP_006526296.1

      UniProtKB/TrEMBL
      A0A494BAP2
      Related
      ENSMUSP00000158175.2, ENSMUST00000237880.2
      Conserved Domains (2) summary
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:329 → 418
      CK1gamma_C; Casein kinase 1 gamma C terminal

    3. XM_006526232.2 → XP_006526295.1  casein kinase I isoform X3

      Conserved Domains (2) summary
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:329 → 416
      CK1gamma_C; Casein kinase 1 gamma C terminal

    4. XM_006526236.1 → XP_006526299.1  casein kinase I isoform X7

      See identical proteins and their annotated locations for XP_006526299.1

      Conserved Domains (2) summary
      cd14126
      Location:42 → 329
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:329 → 386
      CK1gamma_C; Casein kinase 1 gamma C terminal

    5. XM_006526231.2 → XP_006526294.1  casein kinase I isoform X2

      Conserved Domains (2) summary
      cd14126
      Location:42 → 328
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:328 → 417
      CK1gamma_C; Casein kinase 1 gamma C terminal

    6. XM_006526234.2 → XP_006526297.1  casein kinase I isoform X5

      Conserved Domains (2) summary
      cd14126
      Location:42 → 328
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:328 → 417
      CK1gamma_C; Casein kinase 1 gamma C terminal

    7. XM_006526235.1 → XP_006526298.1  casein kinase I isoform X6

      Conserved Domains (2) summary
      cd14126
      Location:42 → 328
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:328 → 385
      CK1gamma_C; Casein kinase 1 gamma C terminal

    8. XM_006526237.1 → XP_006526300.1  casein kinase I isoform X8

      Conserved Domains (2) summary
      cd14126
      Location:42 → 328
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:328 → 385
      CK1gamma_C; Casein kinase 1 gamma C terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C4X2.2 GenPept UniProtKB/Swiss-Prot:Q8C4X2

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