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    CREM cAMP responsive element modulator [ Homo sapiens (human) ]

    Gene ID: 1390, updated on 28-Oct-2024

    Summary

    Official Symbol
    CREMprovided by HGNC
    Official Full Name
    cAMP responsive element modulatorprovided by HGNC
    Primary source
    HGNC:HGNC:2352
    See related
    Ensembl:ENSG00000095794 MIM:123812; AllianceGenome:HGNC:2352
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ICER; CREM-2; hCREM-2
    Summary
    This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 19.2), adrenal (RPKM 15.7) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CREM in Genome Data Viewer
    Location:
    10p11.21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (35126846..35212958)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (35155414..35241554)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35415774..35501886)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902409 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:35301624-35302194 Neighboring gene cullin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2298 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:35379443-35379631 Neighboring gene microRNA 3611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3263 Neighboring gene RNA, U7 small nuclear 77 pseudogene Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 4 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:35500215-35500774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:35503415-35503916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:35517588-35518088 Neighboring gene long intergenic non-protein coding RNA 2634 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:35536556-35536734 Neighboring gene RNA, U6 small nuclear 794, pseudogene Neighboring gene RNA, U6 small nuclear 1167, pseudogene Neighboring gene cyclin Y

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Treatment of dopaminergic rat PC12 cells with HIV-1 Tat downregulates the expression of tyrosine hydroxylase (TH) by upregulating the expression of the inducible cAMP early repressor which in turn abrogates the transcription activity of the TH promoter PubMed
    tat Extracellular HIV-1 Tat protein activates the inducible cAMP early repressor (ICER) in both the Jurkat cell line and primary peripheral blood mononuclear cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC17881, MGC41893, MGC111110

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of ATF4-CREB1 transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    cAMP-responsive element modulator
    Names
    CREM 2alpha-b protein
    CREM 2beta-a protein
    cAMP response element modulator
    inducible cAMP early repressor ICER

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029065.1 RefSeqGene

      Range
      4974..91081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267562.2NP_001254491.1  cAMP-responsive element modulator isoform 23

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23) has an alternate first exon, lacks the exon containing the translation start codon, and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (23) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG573680, BI459432
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (1) summary
      cd14690
      Location:122176
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    2. NM_001267563.2NP_001254492.1  cAMP-responsive element modulator isoform 24

      See identical proteins and their annotated locations for NP_001254492.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24) has an alternate first exon and lacks three other exons compared to variant 1. The resulting isoform (24) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AL117336, AL157783, BC041810, CB996061
      Conserved Domains (1) summary
      cd14690
      Location:59113
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    3. NM_001267564.2NP_001254493.1  cAMP-responsive element modulator isoform 25

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25) uses an alternate first exon in place of the first three exons and contains an alternate in-frame exon compared to variant 1. The resulting isoform (25) has a shorter and distinct N-terminus and contains an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BU193626, CD358637
      Consensus CDS
      CCDS58074.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000379225.3, ENST00000395887.8
      Conserved Domains (1) summary
      cd14690
      Location:225279
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    4. NM_001267565.2NP_001254494.1  cAMP-responsive element modulator isoform 26

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (26) has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      BU193626, BU570307, CK300763
      Conserved Domains (2) summary
      pfam02173
      Location:6683
      pKID; pKID domain
      pfam13900
      Location:3267
      GVQW; Putative domain of unknown function
    5. NM_001267566.2NP_001254495.1  cAMP-responsive element modulator isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (27) has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      BP370901, BU570307, CK300763
      Conserved Domains (1) summary
      pfam02173
      Location:1350
      pKID; pKID domain
    6. NM_001267567.2NP_001254496.1  cAMP-responsive element modulator isoform 28

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28) has an alternate first exon in place of the first five exons compared to variant 1. The resulting isoform (28) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL117336, BC041810, BG720999
      Consensus CDS
      CCDS58075.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000418336.1, ENST00000463314.5
      Conserved Domains (1) summary
      cd14690
      Location:81135
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    7. NM_001267568.2NP_001254497.1  cAMP-responsive element modulator isoform 29

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29) has an alternate exon in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (29) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AL117336, AW439476, CD639591, CD640977
    8. NM_001267569.2NP_001254498.1  cAMP-responsive element modulator isoform 30

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30) has two alternate exons in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (30) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AL117336, AW439476, CD640977
    9. NM_001267570.2NP_001254499.1  cAMP-responsive element modulator isoform 31

      Status: REVIEWED

      Description
      Transcript Variant: This variant (31) has two alternate exons in place of the first six exons compared to variant 1. The resulting isoform (31) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK289379, AL117336, BC041810, CD640465
      Consensus CDS
      CCDS58076.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000419810.1, ENST00000468236.5
      Conserved Domains (1) summary
      cd14690
      Location:68122
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    10. NM_001352445.1NP_001339374.1  cAMP-responsive element modulator isoform 32

      Status: REVIEWED

      Source sequence(s)
      AK289379, AL117336, AL157783, BC041810, DA823429, HY169431
      Consensus CDS
      CCDS53522.1
      UniProtKB/TrEMBL
      E9PAR2
      Related
      ENSP00000344365.5, ENST00000344351.5
      Conserved Domains (1) summary
      cd14690
      Location:3993
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    11. NM_001352446.1NP_001339375.1  cAMP-responsive element modulator isoform 33

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783, BC041810, CD686814, D79104, DA823429, DT220562
      Consensus CDS
      CCDS53523.1
      UniProtKB/TrEMBL
      E9PB41
      Conserved Domains (1) summary
      cd14690
      Location:3993
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    12. NM_001352465.2NP_001339394.1  cAMP-responsive element modulator isoform 33

      Status: REVIEWED

      Source sequence(s)
      AA453346, AL117336, AL157783, BC041810
      Consensus CDS
      CCDS53523.1
      UniProtKB/TrEMBL
      E9PB41
      Related
      ENSP00000419018.1, ENST00000474362.5
      Conserved Domains (1) summary
      cd14690
      Location:3993
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    13. NM_001352466.2NP_001339395.1  cAMP-responsive element modulator isoform 32

      Status: REVIEWED

      Source sequence(s)
      AL117336, BC041810, CN367927
      Consensus CDS
      CCDS53522.1
      UniProtKB/TrEMBL
      E9PAR2
      Related
      ENSP00000420437.1, ENST00000460270.5
      Conserved Domains (1) summary
      cd14690
      Location:3993
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    14. NM_001352467.2NP_001339396.1  cAMP-responsive element modulator isoform 32

      Status: REVIEWED

      Source sequence(s)
      AL117336, BC041810, DR760671
      Consensus CDS
      CCDS53522.1
      UniProtKB/TrEMBL
      E9PAR2
      Conserved Domains (1) summary
      cd14690
      Location:3993
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    15. NM_001394595.1NP_001381524.1  cAMP-responsive element modulator isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Consensus CDS
      CCDS7180.1
      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Related
      ENSP00000510546.1, ENST00000686585.1
      Conserved Domains (2) summary
      cd14690
      Location:243297
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:69105
      pKID; pKID domain
    16. NM_001394598.1NP_001381527.1  cAMP-responsive element modulator isoform 34

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Conserved Domains (2) summary
      cd14690
      Location:239293
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:5389
      pKID; pKID domain
    17. NM_001394600.1NP_001381529.1  cAMP-responsive element modulator isoform 35

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Conserved Domains (2) summary
      cd14690
      Location:227281
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:5389
      pKID; pKID domain
    18. NM_001394602.1NP_001381531.1  cAMP-responsive element modulator isoform 36

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Conserved Domains (2) summary
      cd14690
      Location:227281
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:5389
      pKID; pKID domain
    19. NM_001394603.1NP_001381532.1  cAMP-responsive element modulator isoform 37

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      pfam02173
      Location:5389
      pKID; pKID domain
    20. NM_001394605.1NP_001381534.1  cAMP-responsive element modulator isoform 38

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (2) summary
      cd14690
      Location:188242
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:1450
      pKID; pKID domain
    21. NM_001394608.1NP_001381537.1  cAMP-responsive element modulator isoform 39

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Related
      ENSP00000419684.2, ENST00000463960.5
      Conserved Domains (2) summary
      cd14690
      Location:176230
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:5389
      pKID; pKID domain
    22. NM_001394610.1NP_001381539.1  cAMP-responsive element modulator isoform 40

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/TrEMBL
      G5E998
      Conserved Domains (2) summary
      cd14690
      Location:176230
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:5389
      pKID; pKID domain
    23. NM_001394613.1NP_001381542.1  cAMP-responsive element modulator isoform 22

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Consensus CDS
      CCDS7183.1
      UniProtKB/TrEMBL
      G5E998
      Conserved Domains (2) summary
      cd14690
      Location:164218
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:5389
      pKID; pKID domain
    24. NM_001394614.1NP_001381543.1  cAMP-responsive element modulator isoform 42

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/TrEMBL
      C9IYM9
      Conserved Domains (2) summary
      cd14690
      Location:164218
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:5389
      pKID; pKID domain
    25. NM_001394615.1NP_001381544.1  cAMP-responsive element modulator isoform 43

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      cd14690
      Location:134188
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    26. NM_001394616.1NP_001381545.1  cAMP-responsive element modulator isoform 44

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/TrEMBL
      C9IYM9
      Conserved Domains (1) summary
      pfam02173
      Location:5389
      pKID; pKID domain
    27. NM_001394617.1NP_001381546.1  cAMP-responsive element modulator isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      cd14690
      Location:122176
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    28. NM_001394618.1NP_001381547.1  cAMP-responsive element modulator isoform 46

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/TrEMBL
      Q59FC7
      Conserved Domains (1) summary
      cd14690
      Location:122176
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    29. NM_001394619.1NP_001381548.1  cAMP-responsive element modulator isoform 46

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/TrEMBL
      Q59FC7
      Conserved Domains (1) summary
      cd14690
      Location:122176
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    30. NM_001394620.1NP_001381549.1  cAMP-responsive element modulator isoform 47

      Status: REVIEWED

      Source sequence(s)
      AL157783
      UniProtKB/TrEMBL
      A0A0A0MSU8
      Conserved Domains (1) summary
      pfam02173
      Location:69105
      pKID; pKID domain
    31. NM_001394621.1NP_001381550.1  cAMP-responsive element modulator isoform 53

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/TrEMBL
      Q59FC7
      Conserved Domains (1) summary
      cd14690
      Location:93147
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    32. NM_001394622.1NP_001381551.1  cAMP-responsive element modulator isoform 48

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
    33. NM_001394623.1NP_001381552.1  cAMP-responsive element modulator isoform 45

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/TrEMBL
      Q59FC7
      Conserved Domains (1) summary
      cd14690
      Location:81135
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    34. NM_001394625.1NP_001381554.1  cAMP-responsive element modulator isoform 49

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      cd14690
      Location:71125
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    35. NM_001394626.1NP_001381555.1  cAMP-responsive element modulator isoform 50

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      cd14690
      Location:71125
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    36. NM_001394627.1NP_001381556.1  cAMP-responsive element modulator isoform 50

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      cd14690
      Location:71125
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    37. NM_001394628.1NP_001381557.1  cAMP-responsive element modulator isoform 51

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      cd14690
      Location:59113
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    38. NM_001394629.1NP_001381558.1  cAMP-responsive element modulator isoform 51

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      cd14690
      Location:59113
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    39. NM_001394630.1NP_001381559.1  cAMP-responsive element modulator isoform 52

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
    40. NM_001394631.1NP_001381560.1  cAMP-responsive element modulator isoform 54

      Status: REVIEWED

      Source sequence(s)
      AL157783
    41. NM_001881.4NP_001872.3  cAMP-responsive element modulator isoform 2

      See identical proteins and their annotated locations for NP_001872.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. These differences cause translation initiation at a downstream ATG, and result in a shorter isoform (2, also known as b) with a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC017117, BC066342
      Consensus CDS
      CCDS7184.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000363858.3, ENST00000374726.7
      Conserved Domains (1) summary
      pfam02173
      Location:5289
      pKID; pKID domain
    42. NM_181571.3NP_853549.1  cAMP-responsive element modulator isoform 1

      See identical proteins and their annotated locations for NP_853549.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). This isoform represents an activator tau2 isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, BI561543
      Consensus CDS
      CCDS7180.1
      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Related
      ENSP00000265372.5, ENST00000345491.7
      Conserved Domains (2) summary
      cd14690
      Location:243297
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:69105
      pKID; pKID domain
    43. NM_182717.2NP_874386.1  cAMP-responsive element modulator isoform 4

      See identical proteins and their annotated locations for NP_874386.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as ICER1 and hCREM 2alpha-a, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (4, also known as d) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825, D14826
      Consensus CDS
      CCDS7187.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000420681.1, ENST00000473940.5
      Conserved Domains (1) summary
      cd14690
      Location:64118
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    44. NM_182718.2NP_874387.1  cAMP-responsive element modulator isoform 5

      See identical proteins and their annotated locations for NP_874387.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), also known as ICER11 gamma and hCREM 2beta-b, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (5, also known as e) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CN367927, D14826
      Consensus CDS
      CCDS53519.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000417460.1, ENST00000488328.5
      Conserved Domains (1) summary
      cd14690
      Location:52106
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    45. NM_182719.2NP_874388.1  cAMP-responsive element modulator isoform 6

      See identical proteins and their annotated locations for NP_874388.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), also known as ICER11 and hCREM 2beta-a, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (6, also known as f) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825, D14826
      Consensus CDS
      CCDS53517.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000417807.1, ENST00000487763.5
      Conserved Domains (1) summary
      cd14690
      Location:64118
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    46. NM_182720.2NP_874389.1  cAMP-responsive element modulator isoform 7

      See identical proteins and their annotated locations for NP_874389.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), also known as ICER1 gamma and hCREM 2alpha-b, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (7, also known as g) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CN367927, D14826
      Consensus CDS
      CCDS53518.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000349387.5, ENST00000356917.9
      Conserved Domains (1) summary
      cd14690
      Location:52106
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    47. NM_182721.2NP_874390.1  cAMP-responsive element modulator isoform 8

      See identical proteins and their annotated locations for NP_874390.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (8, also known as h) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AK289379, AL117336, BC041810
      Consensus CDS
      CCDS7188.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000417562.1, ENST00000474931.5
      Conserved Domains (1) summary
      cd14690
      Location:56110
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    48. NM_182723.2NP_874392.1  cAMP-responsive element modulator isoform 10

      See identical proteins and their annotated locations for NP_874392.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (10, also known as j) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CD686814
      Consensus CDS
      CCDS53521.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000419075.1, ENST00000488741.5
      Conserved Domains (1) summary
      cd14690
      Location:46100
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    49. NM_182724.2NP_874393.1  cAMP-responsive element modulator isoform 11

      See identical proteins and their annotated locations for NP_874393.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (11, also known as k) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AK289379, AL117336, BC041810
      Consensus CDS
      CCDS53520.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000417327.1, ENST00000490511.1
      Conserved Domains (1) summary
      cd14690
      Location:56110
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    50. NM_182769.3NP_877570.1  cAMP-responsive element modulator isoform 13

      See identical proteins and their annotated locations for NP_877570.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), also known as CREM theta2-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (13, also known as m) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 2.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264, BP370901
      Consensus CDS
      CCDS7186.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000341875.3, ENST00000342105.7
      Conserved Domains (2) summary
      cd14690
      Location:188242
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:1350
      pKID; pKID domain
    51. NM_182770.3NP_877571.1  cAMP-responsive element modulator isoform 14

      See identical proteins and their annotated locations for NP_877571.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), also known as CREM theta2-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (14, also known as n) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 2.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264, BP370901
      UniProtKB/TrEMBL
      C9K092
      Conserved Domains (2) summary
      cd14690
      Location:125179
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:1350
      pKID; pKID domain
    52. NM_182771.2NP_877572.1  cAMP-responsive element modulator isoform 15

      See identical proteins and their annotated locations for NP_877572.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), also known as CREM theta1-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (15, also known as o) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264
      Consensus CDS
      CCDS7185.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000354593.4, ENST00000361599.8
      Conserved Domains (2) summary
      cd14690
      Location:213267
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:3875
      pKID; pKID domain
    53. NM_182772.2NP_877573.1  cAMP-responsive element modulator isoform 16

      See identical proteins and their annotated locations for NP_877573.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), also known as CREM theta1-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (16, also known as p) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264
      UniProtKB/TrEMBL
      J3KR46
      Related
      ENSP00000417165.1, ENST00000484283.5
      Conserved Domains (2) summary
      cd14690
      Location:150204
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:3875
      pKID; pKID domain
    54. NM_183011.2NP_898829.1  cAMP-responsive element modulator isoform 21

      See identical proteins and their annotated locations for NP_898829.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), also known as CREM 10, differs in the 5' UTR, 3' UTR, and contains an additional segment in the coding region, compared to variant 1. This results in a shorter isoform (21, also known as u) with a distinct C-terminus, compared to isoform 1. This isoform represents the tau2 activator isoform.
      Source sequence(s)
      AL117336, AL157783
      Consensus CDS
      CCDS7181.1
      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Related
      ENSP00000509489.1, ENST00000685392.1
      Conserved Domains (2) summary
      cd14690
      Location:243297
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68105
      pKID; pKID domain
    55. NM_183012.2NP_898830.1  cAMP-responsive element modulator isoform 20

      See identical proteins and their annotated locations for NP_898830.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), also known as CREM 22, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (20, also known as t) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
      Source sequence(s)
      AL117336, AL157783
      Consensus CDS
      CCDS31181.1
      UniProtKB/TrEMBL
      G5E998
      Related
      ENSP00000363866.3, ENST00000374734.7
      Conserved Domains (2) summary
      cd14690
      Location:180234
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68105
      pKID; pKID domain
    56. NM_183013.3NP_898831.1  cAMP-responsive element modulator isoform 19

      See identical proteins and their annotated locations for NP_898831.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), also known as hCREM type1 alpha, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (19, also known as s) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825, DA756152
      Consensus CDS
      CCDS7182.1
      UniProtKB/TrEMBL
      G5E998
      Related
      ENSP00000346804.3, ENST00000354759.7
      Conserved Domains (2) summary
      cd14690
      Location:192246
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68105
      pKID; pKID domain
    57. NM_183060.3NP_898883.1  cAMP-responsive element modulator isoform 22

      See identical proteins and their annotated locations for NP_898883.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. This variant uses a downstream start codon, compared to variant 1. The resulting isoform (22, also known as v) is shorter and has a shorter N-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
      Source sequence(s)
      AL117336, AL157783, AV707433, BC041810, BI561543
      Consensus CDS
      CCDS7183.1
      UniProtKB/TrEMBL
      G5E998
      Related
      ENSP00000418798.2, ENST00000487132.6
      Conserved Domains (2) summary
      cd14690
      Location:164218
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:5389
      pKID; pKID domain

    RNA

    1. NR_172138.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL157783
    2. NR_172139.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      35126846..35212958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447824.2XP_024303592.1  cAMP-responsive element modulator isoform X2

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Conserved Domains (2) summary
      cd14690
      Location:304358
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:117154
      pKID; pKID domain
    2. XM_047424625.1XP_047280581.1  cAMP-responsive element modulator isoform X1

      Related
      ENSP00000393538.2, ENST00000429130.7
    3. XM_047424628.1XP_047280584.1  cAMP-responsive element modulator isoform X4

    4. XM_047424627.1XP_047280583.1  cAMP-responsive element modulator isoform X3

    5. XM_047424630.1XP_047280586.1  cAMP-responsive element modulator isoform X8

      Related
      ENSP00000363853.3, ENST00000374721.7
    6. XM_047424629.1XP_047280585.1  cAMP-responsive element modulator isoform X7

    7. XM_006717387.4XP_006717450.1  cAMP-responsive element modulator isoform X6

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Conserved Domains (2) summary
      cd14690
      Location:255309
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68105
      pKID; pKID domain
    8. XM_011519324.3XP_011517626.1  cAMP-responsive element modulator isoform X5

      See identical proteins and their annotated locations for XP_011517626.1

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Conserved Domains (2) summary
      cd14690
      Location:255309
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68105
      pKID; pKID domain
    9. XM_006717382.4XP_006717445.1  cAMP-responsive element modulator isoform X11

      See identical proteins and their annotated locations for XP_006717445.1

      UniProtKB/TrEMBL
      G5E998
      Conserved Domains (2) summary
      cd14690
      Location:180234
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68105
      pKID; pKID domain
    10. XM_017015731.2XP_016871220.1  cAMP-responsive element modulator isoform X14

      Conserved Domains (1) summary
      cd14690
      Location:93147
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    11. XM_047424626.1XP_047280582.1  cAMP-responsive element modulator isoform X1

    12. XM_011519325.4XP_011517627.1  cAMP-responsive element modulator isoform X5

      See identical proteins and their annotated locations for XP_011517627.1

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Related
      ENSP00000420511.1, ENST00000479070.5
      Conserved Domains (2) summary
      cd14690
      Location:255309
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68105
      pKID; pKID domain
    13. XM_047424632.1XP_047280588.1  cAMP-responsive element modulator isoform X14

    14. XM_047424636.1XP_047280592.1  cAMP-responsive element modulator isoform X17

      UniProtKB/TrEMBL
      E9PB41
    15. XM_047424631.1XP_047280587.1  cAMP-responsive element modulator isoform X13

    16. XM_011519333.2XP_011517635.1  cAMP-responsive element modulator isoform X13

      Conserved Domains (1) summary
      cd14690
      Location:134188
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    17. XM_011519330.3XP_011517632.1  cAMP-responsive element modulator isoform X9

      Conserved Domains (2) summary
      cd14690
      Location:200254
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:1350
      pKID; pKID domain
    18. XM_011519331.3XP_011517633.1  cAMP-responsive element modulator isoform X10

      Conserved Domains (1) summary
      cd14690
      Location:188242
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    19. XM_011519332.3XP_011517634.1  cAMP-responsive element modulator isoform X12

      Conserved Domains (1) summary
      cd14690
      Location:176230
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    20. XM_011519335.3XP_011517637.1  cAMP-responsive element modulator isoform X14

      See identical proteins and their annotated locations for XP_011517637.1

      Conserved Domains (1) summary
      cd14690
      Location:93147
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    21. XM_047424634.1XP_047280590.1  cAMP-responsive element modulator isoform X16

    22. XM_047424635.1XP_047280591.1  cAMP-responsive element modulator isoform X16

    23. XM_047424637.1XP_047280593.1  cAMP-responsive element modulator isoform X17

      UniProtKB/TrEMBL
      E9PB41
    24. XM_047424633.1XP_047280589.1  cAMP-responsive element modulator isoform X15

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      35155414..35241554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364838.1XP_054220813.1  cAMP-responsive element modulator isoform X2

    2. XM_054364836.1XP_054220811.1  cAMP-responsive element modulator isoform X1

    3. XM_054364840.1XP_054220815.1  cAMP-responsive element modulator isoform X4

    4. XM_054364839.1XP_054220814.1  cAMP-responsive element modulator isoform X3

    5. XM_054364845.1XP_054220820.1  cAMP-responsive element modulator isoform X8

    6. XM_054364844.1XP_054220819.1  cAMP-responsive element modulator isoform X7

    7. XM_054364843.1XP_054220818.1  cAMP-responsive element modulator isoform X6

    8. XM_054364841.1XP_054220816.1  cAMP-responsive element modulator isoform X5

    9. XM_054364848.1XP_054220823.1  cAMP-responsive element modulator isoform X11

    10. XM_054364854.1XP_054220829.1  cAMP-responsive element modulator isoform X14

    11. XM_054364837.1XP_054220812.1  cAMP-responsive element modulator isoform X1

    12. XM_054364842.1XP_054220817.1  cAMP-responsive element modulator isoform X5

    13. XM_054364853.1XP_054220828.1  cAMP-responsive element modulator isoform X14

    14. XM_054364858.1XP_054220833.1  cAMP-responsive element modulator isoform X17

      UniProtKB/TrEMBL
      E9PB41
    15. XM_054364850.1XP_054220825.1  cAMP-responsive element modulator isoform X13

    16. XM_054364851.1XP_054220826.1  cAMP-responsive element modulator isoform X13

    17. XM_054364846.1XP_054220821.1  cAMP-responsive element modulator isoform X9

    18. XM_054364847.1XP_054220822.1  cAMP-responsive element modulator isoform X10

    19. XM_054364849.1XP_054220824.1  cAMP-responsive element modulator isoform X12

    20. XM_054364852.1XP_054220827.1  cAMP-responsive element modulator isoform X14

    21. XM_054364856.1XP_054220831.1  cAMP-responsive element modulator isoform X16

    22. XM_054364857.1XP_054220832.1  cAMP-responsive element modulator isoform X16

    23. XM_054364859.1XP_054220834.1  cAMP-responsive element modulator isoform X17

      UniProtKB/TrEMBL
      E9PB41
    24. XM_054364855.1XP_054220830.1  cAMP-responsive element modulator isoform X15

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182722.1: Suppressed sequence

      Description
      NM_182722.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    2. NM_182725.1: Suppressed sequence

      Description
      NM_182725.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    3. NM_182850.2: Suppressed sequence

      Description
      NM_182850.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    4. NM_182853.2: Suppressed sequence

      Description
      NM_182853.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.