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    ZNF675 zinc finger protein 675 [ Homo sapiens (human) ]

    Gene ID: 171392, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF675provided by HGNC
    Official Full Name
    zinc finger protein 675provided by HGNC
    Primary source
    HGNC:HGNC:30768
    See related
    Ensembl:ENSG00000197372 MIM:620090; AllianceGenome:HGNC:30768
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIZ; TBZF
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in negative regulation of osteoclast differentiation; negative regulation of signal transduction; and regulation of DNA-templated transcription. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 3.0), testis (RPKM 2.9) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF675 in Genome Data Viewer
    Location:
    19p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (23652801..23687212, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (23792325..23826770, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (23835603..23870014, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27 pseudogene 29 Neighboring gene vomeronasal 1 receptor 93 pseudogene Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:23848667-23849407 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:23868450-23869420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14394 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23906366-23907280 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:23941373-23941891 Neighboring gene vomeronasal 1 receptor 94 pseudogene Neighboring gene zinc finger protein 681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:23944886-23945526 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23945527-23946168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:23951857-23952358 Neighboring gene ribosomal protein SA 2 Neighboring gene BCL2 interacting protein 3 pseudogene 39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Recognition specificity of self-incompatibility maintained after the divergence of Brassica oleracea and Brassica rapa. Kimura R, et al. Plant J, 2002 Jan. PMID 11851921
    2. Emergence of the ZNF675 Gene During Primate Evolution-Influenced Human Neurodevelopment Through Changing HES1 Autoregulation. Lodewijk GA, et al. J Comp Neurol, 2024 Jul. PMID 38958676
    3. A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6. Shin JN, et al. J Biol Chem, 2002 Mar 8. PMID 11751921
    4. Functional proteomics mapping of a human signaling pathway. Colland F, et al. Genome Res, 2004 Jul. PMID 15231748, Free PMC Article
    5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Emergence of the ZNF675 Gene During Primate Evolution-Influenced Human Neurodevelopment Through Changing HES1 Autoregulation.
      Title: Emergence of the ZNF675 Gene During Primate Evolution-Influenced Human Neurodevelopment Through Changing HES1 Autoregulation.
    2. the novel zinc finger protein TIZ may play a role during osteoclast differentiation by modulating TRAF6 signaling activity.
      Title: A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36350

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bone resorption TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-1-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 675
    Names
    TRAF6 inhibitory zinc finger
    TRAF6-binding zinc finger protein
    TRAF6-inhibitory zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138330.3 → NP_612203.2  zinc finger protein 675

      See identical proteins and their annotated locations for NP_612203.2

      Status: VALIDATED

      Source sequence(s)
      AC073544, DA777369
      Consensus CDS
      CCDS32981.1
      UniProtKB/Swiss-Prot
      Q8N211, Q8TD23
      Related
      ENSP00000352836.3, ENST00000359788.9
      Conserved Domains (6) summary
      smart00349
      Location:4 → 62
      KRAB; krueppel associated box
      COG5048
      Location:169 → 556
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:314 → 334
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:174 → 194
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:494 → 519
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      23652801..23687212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438379.1 → XP_047294335.1  zinc finger protein 675 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      23792325..23826770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320136.1 → XP_054176111.1  zinc finger protein 675 isoform X1

    2. XM_054320135.1 → XP_054176110.1  zinc finger protein 675 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TD23.3 GenPept UniProtKB/Swiss-Prot:Q8TD23

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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