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    STRIP1 striatin interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 85369, updated on 27-Nov-2024

    Summary

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    Official Symbol
    STRIP1provided by HGNC
    Official Full Name
    striatin interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:25916
    See related
    Ensembl:ENSG00000143093 MIM:617918; AllianceGenome:HGNC:25916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM40A; FAR11A
    Summary
    This gene encodes a member of the striatin-interacting phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
    Expression
    Ubiquitous expression in testis (RPKM 12.7), bone marrow (RPKM 10.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STRIP1 in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (110031577..110054641)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (110041710..110064768)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110574199..110597263)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110453680-110454180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110454181-110454681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110473698-110474646 Neighboring gene colony stimulating factor 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110502441-110503012 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110503013-110503582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1164 Neighboring gene adenosylhomocysteinase like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1458 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:110560640-110561839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1459 Neighboring gene uncharacterized LOC105378895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1460 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1166 Neighboring gene ALX homeobox 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1167 Neighboring gene long intergenic non-protein coding RNA 1397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1461

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization. Kean MJ, et al. J Biol Chem, 2011 Jul 15. PMID 21561862, Free PMC Article
    2. The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs. Suryavanshi N, et al. BMC Cell Biol, 2018 Dec 3. PMID 30509168, Free PMC Article
    3. Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Tang Y, et al. Cell Discov, 2019. PMID 30622739, Free PMC Article
    4. Cryo-EM structure of the Hippo signaling integrator human STRIPAK. Jeong BC, et al. Nat Struct Mol Biol, 2021 Mar. PMID 33633399, Free PMC Article
    5. Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae. Kemp HA, et al. Mol Cell Biol, 2003 Mar. PMID 12588993, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results demonstrate the importance of the FAM40 proteins for endothelial cell physiology, and suggest that they act as part of the CCM3-containing STRIPAK complex.
      Title: The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs.
    2. STRIP1 is required for mesenchymal cell migration and is enriched in cellular protrusions in mesenchymal migrating cells.
      Title: STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo.
    3. this study propose that the STRIPAK complex, FAM40A, FAM40B and STRN3, regulates the mode of cancer cell migration by controlling the activity of MST3 and 4, which locally coordinate the phosphorylation of ERM proteins and inhibit the dephosphorylation of MLC leading to increased actin-membrane linkage.
      Title: STRIPAK components determine mode of cancer cell migration and metastasis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14743, KIAA1761, MGC148091, RP4-773N10.1, 6330569M22Rik

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of hippo signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    striatin-interacting protein 1
    Names
    FAR11 factor arrest 11 homolog A
    family with sequence similarity 40, member A
    homolog of yeast FAR11 protein 1
    protein FAM40A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270768.2 → NP_001257697.1  striatin-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001257697.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK027649, AL772411, BC040142
      Consensus CDS
      CCDS59197.1
      UniProtKB/TrEMBL
      A8K4U4
      Related
      ENSP00000358811.1, ENST00000369796.5
      Conserved Domains (2) summary
      pfam07923
      Location:2 → 231
      N1221; N1221-like protein
      pfam11882
      Location:365 → 688
      DUF3402; Domain of unknown function (DUF3402)

    2. NM_033088.4 → NP_149079.2  striatin-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_149079.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AB051548, BC040142, CB960147
      Consensus CDS
      CCDS30798.1
      UniProtKB/Swiss-Prot
      Q0V925, Q5VSL8, Q5VSL9, Q658K2, Q6ZV31, Q8N598, Q96SN2, Q9C0A2
      UniProtKB/TrEMBL
      A8K4U4
      Related
      ENSP00000358810.3, ENST00000369795.8
      Conserved Domains (2) summary
      pfam07923
      Location:66 → 336
      N1221; N1221-like protein
      pfam11882
      Location:460 → 783
      DUF3402; Domain of unknown function (DUF3402)

    RNA

    1. NR_073071.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL834196, BC040142, DB460380
      Related
      ENST00000485775.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      110031577..110054641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432935.1 → XP_047288891.1  striatin-interacting protein 1 isoform X2

    2. XM_006710995.3 → XP_006711058.1  striatin-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      Q8WUN4
      Conserved Domains (1) summary
      pfam11882
      Location:154 → 477
      DUF3402; Domain of unknown function (DUF3402)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      110041710..110064768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339317.1 → XP_054195292.1  striatin-interacting protein 1 isoform X2

    2. XM_054339316.1 → XP_054195291.1  striatin-interacting protein 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VSL9.1 GenPept UniProtKB/Swiss-Prot:Q5VSL9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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