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    STAM signal transducing adaptor molecule [ Homo sapiens (human) ]

    Gene ID: 8027, updated on 3-Dec-2024

    Summary

    Official Symbol
    STAMprovided by HGNC
    Official Full Name
    signal transducing adaptor moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:11357
    See related
    Ensembl:ENSG00000136738 MIM:601899; AllianceGenome:HGNC:11357
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STAM1; STAM-1
    Summary
    This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in bone marrow (RPKM 13.8), brain (RPKM 7.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STAM in Genome Data Viewer
    Location:
    10p12.33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (17644151..17716824)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (17662652..17736129)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (17686150..17758823)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2183 Neighboring gene 3-hydroxyacyl-CoA dehydratase 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:17664851-17665073 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:17685104-17685752 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:17685753-17686402 Neighboring gene STAM divergent transcript Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:17713088-17713842 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:17715682-17716218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:17728822-17729322 Neighboring gene MPRA-validated peak889 silencer Neighboring gene transmembrane protein 236 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:17829359-17829976 Neighboring gene mannose receptor C-type 1 Neighboring gene microRNA 511

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp686J2352

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-like protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of ESCRT-0 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ESCRT-0 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ESCRT-0 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of ESCRT-0 complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    signal transducing adapter molecule 1
    Names
    HSE1 homolog
    signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324282.2NP_001311211.1  signal transducing adapter molecule 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC069542
      UniProtKB/TrEMBL
      B2RAY1
    2. NM_001324283.2NP_001311212.1  signal transducing adapter molecule 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform c.
      Source sequence(s)
      AC069542
      UniProtKB/TrEMBL
      B2RAY1
      Conserved Domains (3) summary
      cd11964
      Location:163217
      SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
      pfam03127
      Location:256327
      GAT; GAT domain
      cl02544
      Location:192
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
    3. NM_001324284.2NP_001311213.1  signal transducing adapter molecule 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.
      Source sequence(s)
      AC069542
      UniProtKB/TrEMBL
      B2RAY1
      Conserved Domains (3) summary
      cd11964
      Location:163217
      SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
      pfam03127
      Location:256327
      GAT; GAT domain
      cl02544
      Location:192
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
    4. NM_001324285.2NP_001311214.1  signal transducing adapter molecule 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.
      Source sequence(s)
      AC069542
      UniProtKB/TrEMBL
      B2RAY1
      Conserved Domains (3) summary
      cd11964
      Location:163217
      SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
      pfam03127
      Location:256327
      GAT; GAT domain
      cl02544
      Location:192
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
    5. NM_001324286.2NP_001311215.1  signal transducing adapter molecule 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC069542
      UniProtKB/TrEMBL
      B2RAY1
    6. NM_001324287.2NP_001311216.1  signal transducing adapter molecule 1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC069542
      UniProtKB/TrEMBL
      B4DZT2
      Conserved Domains (3) summary
      cd11964
      Location:102156
      SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
      pfam03127
      Location:195266
      GAT; GAT domain
      cl02544
      Location:131
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
    7. NM_001324288.2NP_001311217.1  signal transducing adapter molecule 1 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) and variant 9 both encode isoform f.
      Source sequence(s)
      AC069542
    8. NM_001324289.2NP_001311218.1  signal transducing adapter molecule 1 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) and variant 8 both encode isoform f.
      Source sequence(s)
      AC069542
    9. NM_003473.4NP_003464.1  signal transducing adapter molecule 1 isoform a

      See identical proteins and their annotated locations for NP_003464.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC069542, AU118708, U43899
      Consensus CDS
      CCDS7122.1
      UniProtKB/Swiss-Prot
      B0YJ99, D3DRU5, Q8N6D9, Q92783
      UniProtKB/TrEMBL
      B2RAY1
      Related
      ENSP00000366746.3, ENST00000377524.8
      Conserved Domains (3) summary
      cd11964
      Location:213267
      SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
      cd17000
      Location:9139
      VHS_STAM1; VHS (Vps27/Hrs/STAM) domain of Signal Transducing Adapter Molecule 1
      cd21389
      Location:301377
      GAT_STAM1; non-canonical GAT domain found in signal transducing adapter molecule 1 (STAM-1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      17644151..17716824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519695.4XP_011517997.1  signal transducing adapter molecule 1 isoform X1

      UniProtKB/TrEMBL
      B2RAY1
      Conserved Domains (3) summary
      cd11964
      Location:213267
      SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
      cd03568
      Location:9142
      VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
      pfam03127
      Location:306377
      GAT; GAT domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      17662652..17736129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366801.1XP_054222776.1  signal transducing adapter molecule 1 isoform X1

      UniProtKB/TrEMBL
      B2RAY1