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    BMPR1A bone morphogenetic protein receptor type 1A [ Homo sapiens (human) ]

    Gene ID: 657, updated on 3-Dec-2024

    Summary

    Official Symbol
    BMPR1Aprovided by HGNC
    Official Full Name
    bone morphogenetic protein receptor type 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:1076
    See related
    Ensembl:ENSG00000107779 MIM:601299; AllianceGenome:HGNC:1076
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALK3; SKR5; ALK-3; CD292; ACVRLK3; BMPR-1A; 10q23del
    Summary
    The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 14.8), endometrium (RPKM 10.0) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BMPR1A in Genome Data Viewer
    Location:
    10q23.2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (86755763..86932844)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (87639833..87816596)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (88515520..88692601)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3695 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:88433149-88433337 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_17910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88441665-88442166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88442167-88442666 Neighboring gene VISTA enhancer hs2143 Neighboring gene opsin 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88459642-88460142 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88460143-88460643 Neighboring gene LIM domain binding 3 Neighboring gene hESC enhancers GRCh37_chr10:88470545-88471164 and GRCh37_chr10:88471165-88471784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2573 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:88552774-88553500 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:88597221-88597813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88615649-88616230 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88624164-88624816 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88624817-88625468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88627361-88627948 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88631460-88632021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3697 Neighboring gene RNA polymerase II associated protein 2 pseudogene 1 Neighboring gene RNA, U1 small nuclear 19, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88700126-88700626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88704401-88704974 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88713843-88714442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88715044-88715643 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88718646-88719245 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88720446-88721046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88721647-88722246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88726172-88726925 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88726926-88727678 Neighboring gene Sharpr-MPRA regulatory region 6517 Neighboring gene multimerin 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:88730527-88731726 Neighboring gene ADIRF antisense RNA 1 Neighboring gene synuclein gamma Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 11 Neighboring gene adipogenesis regulatory factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Juvenile polyposis syndrome
    MedGen: C0345893 OMIM: 174900 GeneReviews: Juvenile Polyposis Syndrome
    Compare labs
    Polyposis syndrome, hereditary mixed, 2
    MedGen: C1864730 OMIM: 610069 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2020-06-24)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2020-06-24)

    ClinGen Genome Curation PagePubMed

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Treatment of pulmonary arterial smooth muscle cells with HIV-1 gp120 downregulates expression of BMPR-2, BMPR-1A, and BMPR-1B proteins PubMed
    Nef nef Treatment of pulmonary arterial smooth muscle cells with HIV-1 Nef downregulates expression of BMPR-2, BMPR-1A, and BMPR-1B proteins PubMed
    Tat tat Treatment of pulmonary arterial smooth muscle cells with HIV-1 Tat modulates expression of BMPR-2, BMPR-1A, and BMPR-1B proteins PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables BMP binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables BMP receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables BMP receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables SMAD binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables activin receptor activity, type I IEA
    Inferred from Electronic Annotation
    more info
     
    enables activin receptor activity, type II IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transforming growth factor beta receptor activity, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transforming growth factor beta receptor activity, type I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transforming growth factor beta receptor activity, type II IEA
    Inferred from Electronic Annotation
    more info
     
    enables transforming growth factor beta receptor activity, type III IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in BMP signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in Mullerian duct regression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in atrioventricular node cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in atrioventricular valve development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cardiac conduction system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cardiac right ventricle morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to BMP stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in central nervous system neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in developmental growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dorsal aorta morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dorsal/ventral axis specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dorsal/ventral pattern formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ectoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic organ development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endocardial cushion formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endocardial cushion morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibrous ring of heart morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heart formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hindlimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lateral mesoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesendoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesoderm formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitral valve morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural crest cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural plate mediolateral regionalization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in outflow tract morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in outflow tract septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in paraxial mesoderm structural organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pharyngeal arch artery morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pituitary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of SMAD protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cardiac muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cardiac ventricle development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dendrite development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mesenchymal cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of miRNA transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transforming growth factor beta2 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in regulation of cardiac muscle cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cardiac muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of lateral mesodermal cell fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in regulation of neural crest cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in roof of mouth development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in somatic stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tricuspid valve morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ventricular compact myocardium morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ventricular septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ventricular trabecula myocardium morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of HFE-transferrin receptor complex IC
    Inferred by Curator
    more info
    PubMed 
    colocalizes_with caveola IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    bone morphogenetic protein receptor type-1A
    Names
    BMP type-1A receptor
    activin A receptor, type II-like kinase 3
    activin receptor-like kinase 3
    bone morphogenetic protein receptor, type IA
    serine/threonine-protein kinase receptor R5
    NP_001393488.1
    NP_001393489.1
    NP_001393490.1
    NP_001393491.1
    NP_001393492.1
    NP_001393493.1
    NP_001393494.1
    NP_001393495.1
    NP_001393496.1
    NP_001393497.1
    NP_001393498.1
    NP_001393499.1
    NP_001393500.1
    NP_001393501.1
    NP_001393502.1
    NP_001393503.1
    NP_001393504.1
    NP_001393505.1
    NP_001393506.1
    NP_001393507.1
    NP_001393508.1
    NP_001393509.1
    NP_001393510.1
    NP_001393511.1
    NP_001393512.1
    NP_001393513.1
    NP_001393514.1
    NP_001393515.1
    NP_001393516.1
    NP_001393517.1
    NP_001393518.1
    NP_004320.2
    XP_047281636.1
    XP_054222620.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009362.1 RefSeqGene

      Range
      5001..173550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_298

    mRNA and Protein(s)

    1. NM_001406559.1NP_001393488.1  bone morphogenetic protein receptor type-1A isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/TrEMBL
      B5BUG9
    2. NM_001406560.1NP_001393489.1  bone morphogenetic protein receptor type-1A isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/TrEMBL
      B5BUG9
    3. NM_001406561.1NP_001393490.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      Consensus CDS
      CCDS7378.1
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
      Related
      ENSP00000483569.2, ENST00000480152.3
    4. NM_001406562.1NP_001393491.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      Consensus CDS
      CCDS7378.1
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    5. NM_001406563.1NP_001393492.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      Consensus CDS
      CCDS7378.1
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    6. NM_001406564.1NP_001393493.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      Consensus CDS
      CCDS7378.1
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    7. NM_001406565.1NP_001393494.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    8. NM_001406566.1NP_001393495.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      Consensus CDS
      CCDS7378.1
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    9. NM_001406567.1NP_001393496.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    10. NM_001406568.1NP_001393497.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      Consensus CDS
      CCDS7378.1
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
      Related
      ENSP00000518971.1, ENST00000713669.1
    11. NM_001406569.1NP_001393498.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    12. NM_001406570.1NP_001393499.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    13. NM_001406571.1NP_001393500.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    14. NM_001406572.1NP_001393501.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    15. NM_001406573.1NP_001393502.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    16. NM_001406574.1NP_001393503.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    17. NM_001406575.1NP_001393504.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    18. NM_001406576.1NP_001393505.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    19. NM_001406577.1NP_001393506.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    20. NM_001406578.1NP_001393507.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
      Related
      ENSP00000518977.1, ENST00000713675.1
    21. NM_001406579.1NP_001393508.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    22. NM_001406580.1NP_001393509.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    23. NM_001406581.1NP_001393510.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    24. NM_001406582.1NP_001393511.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
    25. NM_001406583.1NP_001393512.1  bone morphogenetic protein receptor type-1A isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/TrEMBL
      B5BUG9
    26. NM_001406584.1NP_001393513.1  bone morphogenetic protein receptor type-1A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/TrEMBL
      B5BUG9
    27. NM_001406585.1NP_001393514.1  bone morphogenetic protein receptor type-1A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC025268, AC067750
      UniProtKB/TrEMBL
      B5BUG9
    28. NM_001406586.1NP_001393515.1  bone morphogenetic protein receptor type-1A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC025268, AC067750
      UniProtKB/TrEMBL
      B5BUG9
    29. NM_001406587.1NP_001393516.1  bone morphogenetic protein receptor type-1A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/TrEMBL
      B5BUG9
    30. NM_001406588.1NP_001393517.1  bone morphogenetic protein receptor type-1A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      UniProtKB/TrEMBL
      B5BUG9
      Related
      ENSP00000518975.1, ENST00000713673.1
    31. NM_001406589.1NP_001393518.1  bone morphogenetic protein receptor type-1A isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
    32. NM_004329.3NP_004320.2  bone morphogenetic protein receptor type-1A isoform 3 precursor

      See identical proteins and their annotated locations for NP_004320.2

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
      Consensus CDS
      CCDS7378.1
      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9
      Related
      ENSP00000361107.2, ENST00000372037.8
      Conserved Domains (3) summary
      smart00221
      Location:234521
      STYKc; Protein kinase; unclassified specificity
      cd14220
      Location:238524
      STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor
      pfam01064
      Location:59138
      Activin_recp; Activin types I and II receptor domain

    RNA

    1. NR_176211.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
    2. NR_176212.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750
    3. NR_176213.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC021036, AC025268, AC067750

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      86755763..86932844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425680.1XP_047281636.1  bone morphogenetic protein receptor type-1A isoform X1

      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      87639833..87816596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366645.1XP_054222620.1  bone morphogenetic protein receptor type-1A isoform X1

      UniProtKB/Swiss-Prot
      A8K6U9, P36894, Q8NEN8
      UniProtKB/TrEMBL
      B5BUG9