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    HOXB9 homeobox B9 [ Homo sapiens (human) ]

    Gene ID: 3219, updated on 27-Nov-2024

    Summary

    Official Symbol
    HOXB9provided by HGNC
    Official Full Name
    homeobox B9provided by HGNC
    Primary source
    HGNC:HGNC:5120
    See related
    Ensembl:ENSG00000170689 MIM:142964; AllianceGenome:HGNC:5120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOX2; HOX2E; HOX-2.5
    Summary
    This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in colon (RPKM 12.6), kidney (RPKM 7.0) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HOXB9 in Genome Data Viewer
    Location:
    17q21.32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (48621156..48626358, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (49484752..49489954, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46698518..46703720, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46684881-46685426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46687251-46688071 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46688072-46688891 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46688892-46689712 Neighboring gene homeobox B7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46694872-46695395 Neighboring gene homeobox B8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46702573-46703250 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:46704661-46704816 Neighboring gene HOXB cluster antisense RNA 4 Neighboring gene microRNA 196a-1 Neighboring gene long intergenic non-protein coding RNA 3057 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46718588-46719586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46719587-46720583 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46723751-46724419 Neighboring gene long intergenic non-protein coding RNA 2086

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in embryonic skeletal system morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mammary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proximal/distal pattern formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    homeobox protein Hox-B9
    Names
    homeo box 2E
    homeo box B9
    homeobox protein Hox-2.5
    homeobox protein Hox-2E

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024017.5NP_076922.1  homeobox protein Hox-B9

      See identical proteins and their annotated locations for NP_076922.1

      Status: REVIEWED

      Source sequence(s)
      AK056123, AK056414, BC015565, BX114117, CA426693, DA696753
      Consensus CDS
      CCDS11534.1
      UniProtKB/Swiss-Prot
      B2RDB7, P17482, Q9H1I1
      Related
      ENSP00000309439.5, ENST00000311177.7
      Conserved Domains (2) summary
      pfam00046
      Location:188241
      Homeobox; Homeobox domain
      pfam04617
      Location:1172
      Hox9_act; Hox9 activation region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      48621156..48626358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      49484752..49489954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)