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    ACSL3 acyl-CoA synthetase long chain family member 3 [ Homo sapiens (human) ]

    Gene ID: 2181, updated on 9-Dec-2024

    Summary

    Official Symbol
    ACSL3provided by HGNC
    Official Full Name
    acyl-CoA synthetase long chain family member 3provided by HGNC
    Primary source
    HGNC:HGNC:3570
    See related
    Ensembl:ENSG00000123983 MIM:602371; AllianceGenome:HGNC:3570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACS3; FACL3; LACS3; LACS 3; PRO2194
    Summary
    The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 44.8), brain (RPKM 31.0) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ACSL3 in Genome Data Viewer
    Location:
    2q36.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (222861036..222944639)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (223346613..223427414)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (223725754..223809357)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17169 Neighboring gene Sharpr-MPRA regulatory region 7025 Neighboring gene uncharacterized LOC105373903 Neighboring gene ribosomal protein L31 pseudogene 17 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:223659282-223660204 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:223660205-223661127 Neighboring gene Sharpr-MPRA regulatory region 2575 Neighboring gene Sharpr-MPRA regulatory region 9896 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12374 Neighboring gene NANOG hESC enhancer GRCh37_chr2:223730990-223731491 Neighboring gene MPRA-validated peak4046 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:223770847-223771419 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:223771420-223771991 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:223772163-223772785 Neighboring gene autophagy related 12 pseudogene 2 Neighboring gene ACSL3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12375 Neighboring gene zinc finger protein 79 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17170 Neighboring gene Sharpr-MPRA regulatory region 15139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17171 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:223917216-223917763 Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with acyl-CoA synthetase long-chain family member 3 (ACSL3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables arachidonate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables long-chain fatty acid-CoA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables long-chain fatty acid-CoA ligase activity TAS
    Traceable Author Statement
    more info
     
    enables medium-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables palmitoyl-CoA ligase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    fatty acid CoA ligase Acsl3
    Names
    arachidonate--CoA ligase
    fatty-acid-Coenzyme A ligase, long-chain 3
    lignoceroyl-CoA synthase
    long-chain acyl-CoA synthetase 3
    long-chain-fatty-acid--CoA ligase 3
    medium-chain acyl-CoA ligase Acsl3
    NP_001341087.1
    NP_001341088.1
    NP_004448.2
    NP_976251.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001354158.2NP_001341087.1  fatty acid CoA ligase Acsl3

      Status: REVIEWED

      Source sequence(s)
      AC013476, AC016712
      Consensus CDS
      CCDS2455.1
      UniProtKB/Swiss-Prot
      O95573, Q60I92, Q8IUM9
      UniProtKB/TrEMBL
      B2RBE0
      Related
      ENSP00000505793.1, ENST00000680395.1
      Conserved Domains (1) summary
      cl17068
      Location:30717
      AFD_class_I; Adenylate forming domain, Class I superfamily
    2. NM_001354159.2NP_001341088.1  fatty acid CoA ligase Acsl3

      Status: REVIEWED

      Source sequence(s)
      AC013476, AC016712
      Consensus CDS
      CCDS2455.1
      UniProtKB/Swiss-Prot
      O95573, Q60I92, Q8IUM9
      UniProtKB/TrEMBL
      B2RBE0
      Related
      ENSP00000505400.1, ENST00000680251.1
      Conserved Domains (1) summary
      cl17068
      Location:30717
      AFD_class_I; Adenylate forming domain, Class I superfamily
    3. NM_004457.5NP_004448.2  fatty acid CoA ligase Acsl3

      See identical proteins and their annotated locations for NP_004448.2

      Status: REVIEWED

      Source sequence(s)
      AC013476, BC041692
      Consensus CDS
      CCDS2455.1
      UniProtKB/Swiss-Prot
      O95573, Q60I92, Q8IUM9
      UniProtKB/TrEMBL
      B2RBE0
      Related
      ENSP00000350012.3, ENST00000357430.8
      Conserved Domains (1) summary
      cl17068
      Location:30717
      AFD_class_I; Adenylate forming domain, Class I superfamily
    4. NM_203372.3NP_976251.1  fatty acid CoA ligase Acsl3

      See identical proteins and their annotated locations for NP_976251.1

      Status: REVIEWED

      Source sequence(s)
      AC013476, AC016712
      Consensus CDS
      CCDS2455.1
      UniProtKB/Swiss-Prot
      O95573, Q60I92, Q8IUM9
      UniProtKB/TrEMBL
      B2RBE0
      Related
      ENSP00000375918.3, ENST00000392066.7
      Conserved Domains (1) summary
      cl17068
      Location:30717
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      222861036..222944639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      223346613..223427414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)