ppiaa peptidylprolyl isomerase Aa (cyclophilin A) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppiaaprovided by ZNC
Official Full Name: peptidylprolyl isomerase Aa (cyclophilin A)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8556
See related: Ensembl:ENSDARG00000009212 AllianceGenome:ZFIN:ZDB-GENE-030131-8556
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Cyp1; ppia; PPIA-2; fa93g09; wu:fa93g09; wu:fb05e11; wu:fb13h02; wu:fb15a05
Summary: Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to act upstream of or within apoptotic process and protein peptidyl-prolyl isomerization. Predicted to be located in extracellular region. Predicted to be active in mitochondrion and nucleus. Is expressed in adipose tissue; cerebellum; digestive system; eye; and midbrain. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to human PPIA (peptidylprolyl isomerase A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (45755639..45760087, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (45747764..45752178, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fk94d09.x1 (e-PCR)
- UniSTS:201762

fb13h02.x1 (e-PCR)
- UniSTS:202906

fb15a05.x1 (e-PCR)
- UniSTS:202940

fa93g09 (e-PCR)
- UniSTS:188872

fb05e11.x1 (e-PCR)
- UniSTS:202700

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cyclosporin A binding	IBA Inferred from Biological aspect of Ancestor more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein folding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein peptidyl-prolyl isomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase A

Names: peptidylprolyl isomerase A (cyclophilin A)

NP_997923.2

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.