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    aebp1b AE binding protein 1b [ Danio rerio (zebrafish) ]

    Gene ID: 567630, updated on 14-Nov-2024

    Summary

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    Official Symbol
    aebp1bprovided by ZNC
    Official Full Name
    AE binding protein 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8546
    See related
    Ensembl:ENSDARG00000006901 AllianceGenome:ZFIN:ZDB-GENE-030131-8546
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb14g01; wu:fb14g01; CH1073-459J12.1; si:ch1073-459j12.1
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process; protein processing; and regulation of DNA-templated transcription. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome classic-like 2. Orthologous to human AEBP1 (AE binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See aebp1b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (44759567..44800691)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (44765655..44806787)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene steroidogenic acute regulatory protein Neighboring gene ELMO/CED-12 domain containing 3 Neighboring gene calcium channel, voltage-dependent, L type, alpha 1F subunit a Neighboring gene uncharacterized LOC103911563

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A single-cell transcriptome atlas for zebrafish development. Farnsworth DR, et al. Dev Biol, 2020 Mar 15. PMID 31782996, Free PMC Article
    2. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inactive carboxypeptidase-like protein X2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      44759567..44800691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_690930.10 → XP_696022.6  inactive carboxypeptidase-like protein X2 isoform X1

      UniProtKB/TrEMBL
      A0A8N7TEF3, F1RAC0
      Related
      ENSDARP00000113570.1, ENSDART00000132115.2
      Conserved Domains (6) summary
      cd11308
      Location:1040 → 1115
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:403 → 556
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00410
      Location:62 → 145
      IG_like; Immunoglobulin like
      cd00057
      Location:402 → 555
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl11393
      Location:577 → 1036
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
      cl11960
      Location:56 → 147
      Ig; Immunoglobulin domain

    2. XM_005167251.5 → XP_005167308.1  inactive carboxypeptidase-like protein X2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BFA8
      Conserved Domains (6) summary
      cd11308
      Location:1039 → 1114
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:402 → 555
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00410
      Location:62 → 145
      IG_like; Immunoglobulin like
      cd00057
      Location:401 → 554
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl11393
      Location:576 → 1035
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
      cl11960
      Location:56 → 147
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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