ube2nb ubiquitin-conjugating enzyme E2Nb [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ube2nbprovided by ZNC
Official Full Name: ubiquitin-conjugating enzyme E2Nbprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1291
See related: Ensembl:ENSDARG00000045877 AllianceGenome:ZFIN:ZDB-GENE-040426-1291
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ube2nl; zgc:63901
Summary: Predicted to enable ubiquitin binding activity; ubiquitin conjugating enzyme activity; and ubiquitin-protein transferase activator activity. Acts upstream of or within DNA damage response. Predicted to be part of UBC13-MMS2 complex. Predicted to be active in nucleus. Orthologous to several human genes including UBE2N (ubiquitin conjugating enzyme E2 N). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (1809562..1818287, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (1960249..1968974, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of DNA double-strand break processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in postreplication repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of postreplication repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein monoubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of UBC13-MMS2 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2Nb

Names: ubc13b

NP_956636.1

EC 6.3.2.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200342.1 → NP_956636.1 ubiquitin-conjugating enzyme E2Nb

See identical proteins and their annotated locations for NP_956636.1

Status: PROVISIONAL

Source sequence(s)

BC053141

UniProtKB/TrEMBL

A0A8M1PB45, Q7T3F3

Related

ENSDARP00000067432.4, ENSDART00000067433.5

Conserved Domains (1) summary

cl00154
Location:4 → 151

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...