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    nob1 NIN1 (RPN12) binding protein 1 homolog [ Danio rerio (zebrafish) ]

    Gene ID: 557254, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nob1provided by ZNC
    Official Full Name
    NIN1 (RPN12) binding protein 1 homologprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3112
    See related
    Ensembl:ENSDARG00000016080 AllianceGenome:ZFIN:ZDB-GENE-030131-3112
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Nob1p; fc27e05; wu:fc27e05; si:ch73-167i17.3
    Summary
    Predicted to enable RNA endonuclease activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to act upstream of or within ribosomal small subunit biogenesis. Predicted to be located in nucleus. Predicted to be part of preribosome, small subunit precursor. Orthologous to human NOB1 (NIN1 (RPN12) binding protein 1 homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nob1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (5860299..5875186, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (5245302..5260449, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene NIP7 nucleolar pre-rRNA processing protein Neighboring gene component of oligomeric golgi complex 8 Neighboring gene WD repeat domain 59 Neighboring gene golgi glycoprotein 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ribosomal small subunit biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, small subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein NOB1
    Names
    nin one binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      5860299..5875186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467739.2 → XP_021323414.1  RNA-binding protein NOB1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PFN4
      Conserved Domains (2) summary
      cd09876
      Location:9 → 112
      PIN_Nob1; PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein Ta0041-like homologs
      pfam08772
      Location:244 → 316
      NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like

    2. XM_678662.10 → XP_683754.2  RNA-binding protein NOB1 isoform X1

      UniProtKB/TrEMBL
      A0A8N7TEG7, I3ISV3
      Related
      ENSDARP00000125998.2, ENSDART00000151727.2
      Conserved Domains (3) summary
      cd09876
      Location:9 → 112
      PIN_Nob1; PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein Ta0041-like homologs
      pfam15017
      Location:140 → 249
      AF1Q; Drug resistance and apoptosis regulator
      pfam08772
      Location:289 → 361
      NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like

    3. XM_009293382.3 → XP_009291657.1  RNA-binding protein NOB1 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AUP7
      Conserved Domains (3) summary
      pfam15017
      Location:69 → 178
      AF1Q; Drug resistance and apoptosis regulator
      pfam08772
      Location:218 → 290
      NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like
      cl14812
      Location:178 → 253
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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