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    fancl FA complementation group L [ Danio rerio (zebrafish) ]

    Gene ID: 406255, updated on 4-Jan-2025

    Summary

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    Official Symbol
    fanclprovided by ZNC
    Official Full Name
    FA complementation group Lprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1045
    See related
    Ensembl:ENSDARG00000007885 AllianceGenome:ZFIN:ZDB-GENE-040426-1045
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66144; zgc:76938
    Summary
    Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within oocyte development. Predicted to be part of Fanconi anaemia nuclear complex. Predicted to be active in nucleus. Is expressed in central nervous system; eye; heart; intermediate cell mass of mesoderm; and reproductive system. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group L. Orthologous to human FANCL (FA complementation group L). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See fancl in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (26703897..26780798)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (26573498..26650348)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487401 Neighboring gene si:rp71-1h3.1 Neighboring gene VRK serine/threonine kinase 2 Neighboring gene coiled-coil domain containing 85A Neighboring gene heme-binding protein soul2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. New insights into the all-testis differentiation in zebrafish with compromised endogenous androgen and estrogen synthesis. Ruan Y, et al. PLoS Genet, 2024 Mar. PMID 38451917, Free PMC Article
    2. Sex reversal in zebrafish fancl mutants is caused by Tp53-mediated germ cell apoptosis. Rodríguez-Marí A, et al. PLoS Genet, 2010 Jul 22. PMID 20661450, Free PMC Article
    3. Identifying candidate genes for 2p15p16.1 microdeletion syndrome using clinical, genomic, and functional analysis. Bagheri H, et al. JCI Insight, 2016 Mar 17. PMID 27699255, Free PMC Article
    4. Zebrafish vasa is required for germ-cell differentiation and maintenance. Hartung O, et al. Mol Reprod Dev, 2014 Oct. PMID 25257909, Free PMC Article
    5. The Fanconi anemia/BRCA gene network in zebrafish: embryonic expression and comparative genomics. Titus TA, et al. Mutat Res, 2009 Jul 31. PMID 19101574, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within interstrand cross-link repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within oocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Fanconi anaemia nuclear complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase FANCL
    Names
    Fanconi anemia, complementation group L
    NP_998147.1
    XP_021336228.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212982.1 → NP_998147.1  E3 ubiquitin-protein ligase FANCL

      See identical proteins and their annotated locations for NP_998147.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066750
      UniProtKB/TrEMBL
      Q6NY39
      Related
      ENSDARP00000003498.7, ENSDART00000020946.8
      Conserved Domains (2) summary
      pfam09765
      Location:12 → 291
      WD-3; WD-repeat region
      pfam11793
      Location:299 → 366
      FANCL_C; FANCL C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      26703897..26780798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480553.2 → XP_021336228.1  E3 ubiquitin-protein ligase FANCL isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q9M3
      Conserved Domains (2) summary
      pfam09765
      Location:1 → 236
      WD-3; WD-repeat region
      cd16490
      Location:247 → 304
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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