Vmn2r81 vomeronasal 2, receptor 81 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vmn2r81provided by MGI
Official Full Name: vomeronasal 2, receptor 81provided by MGI
Primary source: MGI:MGI:2684056
See related: Ensembl:ENSMUSG00000055515 AllianceGenome:MGI:2684056
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: V2rf2; EC1-V2R; EC1-VR2
Summary: Enables G protein-coupled olfactory receptor activity. Acts upstream of or within neuron differentiation and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79083611..79130369)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79247777..79294535)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the number of vomeronasal sensory neurons expressing a locus with a targeted deletion in the coding sequence of V2rf2 that is likely a null mutation, is similar to the number that express intact V2rf2
Title: Coordinated coexpression of two vomeronasal receptor V2R genes per neuron in the mouse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled olfactory receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: vomeronasal 2, receptor 81

Names: EC1-V2R pheromone receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175936.2 → NP_787950.1 vomeronasal 2, receptor 81 precursor

See identical proteins and their annotated locations for NP_787950.1

Status: VALIDATED

Source sequence(s)

AC131066, AC158634

Consensus CDS

CCDS23976.1

UniProtKB/TrEMBL

Q80Z09

Related

ENSMUSP00000020547.9, ENSMUST00000020547.10

Conserved Domains (4) summary

cd06365
Location:38 → 509

PBP1_Pheromone_receptor; Ligand-binding domain of the V2R phermone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily

pfam00003
Location:605 → 838

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:79 → 474

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:518 → 569

NCD3G; Nine Cysteines Domain of family 3 GPCR